2.9%, respectively, and in the deep retinal vascular layer 25.3 6.2% and 61.2 2.6%, respectively. Choriocapillaris density was 62.0 1.5%, and RPC density inside of the disc was 44.3 8.9% and in the peripapillary region 64.9 2.7%. In multivariate analysis, higher superficial and deep parafoveal vascular density were associated with younger age (p = 0.027, p < 0.001, resp.), but not with axial length (Table 1). In contrast, RPC density decreased with longer axial length (and with older age). Radial peripapillary capillary (RPC) density was significantly (p < 0.05) the highest in the inferior temporal region followed by the superior temporal region and the temporal region, and finally the inferior nasal region, the superior nasal region and the nasal region. The finding that density of the macular vascular network of the superficial, deep and choroidal layers was independent of axial length agrees with recent studies in which the length of macular Bruch’s membrane, retinal pigment epithelium cell density in the macular region and the macular retinal thickness were neither associated with axial length (Jonas et al. 2015, 2016a). The increased optic disc–fovea distance in axially myopic eyes was due to the development and enlargement of parapapillary gamma zone, a zone at the temporal disc margin without Bruch’s membrane (Jonas et al. 2016b). It may explain the decrease in the RPC density with longer axial length as longer axial length is correlated with larger parapapillary gamma zone and thus a larger peripapillary surface area (Jonas et al. 2016b). The RPC was greater in the inferior temporal and superior temporal regions than in any other region. It corresponded with the regional distribution of the thickness of the retinal nerve fibre layer and the calibres of retinal arteries (Jonas & Schiro 1993). The associations between a higher RPC density and a higher macular vascular density with younger age may be explained by the physiologic age-related loss in vascularity. As a corollary, the optic nerve fibre count decreases by approximately 0.3% or 4000 fibres per year of life and the thickness of the retinal nerve fibre layer reduces with older age (Budenz et al. 2007). Studies by Yu and colleagues had shown that thicker RPCdensity was correlated with thicker retinal nerve fibre layer thickness (Yu et al. 2015). The correlation between thinner macular vascular density and older age and the association between thinner RPC density and longer axial length may be taken into account in the clinical use of these parameters.
[1]
T. Wong,et al.
Determinants of macular thickness using spectral domain optical coherence tomography in healthy eyes: the Singapore Chinese Eye study.
,
2013,
Investigative ophthalmology & visual science.
[2]
M. Ruíz-Canela,et al.
Multicenter Spanish study of spectral‐domain optical coherence tomography in normal children
,
2013,
Acta ophthalmologica.
[3]
Yun-Mi Song,et al.
Genetic influences on macular thickness in Koreans: the healthy twin study.
,
2011,
Investigative ophthalmology & visual science.
[4]
Steven D. Schwartz,et al.
A PILOT STUDY OF NORMATIVE DATA FOR MACULAR THICKNESS AND VOLUME MEASUREMENTS USING CIRRUS HIGH-DEFINITION OPTICAL COHERENCE TOMOGRAPHY
,
2011,
Retina.
[5]
B. Lorenz,et al.
Comparison of Central Retinal Thickness in Healthy Children and Adults Measured with the Heidelberg Spectralis OCT and the Zeiss Stratus OCT 3
,
2010,
Ophthalmologica.
[6]
A. Alm,et al.
A population‐based study of macular thickness in full‐term children assessed with Stratus OCT: normative data and repeatability
,
2009,
Acta ophthalmologica.
[7]
R. Guymer,et al.
Heritability of macular thickness determined by optical coherence tomography.
,
2006,
Investigative ophthalmology & visual science.