Timing Spatial Conflict within the Parietal Cortex: A TMS Study

Orienting and motor attention are known to recruit different regions within right and left parietal lobes. However, the time course and the role played by these modules when visual information competes for different motor response are still unknown. To deal with this issue, single-pulse TMS was applied over the angular (AG) and the supramarginal (SMG) gyri of both hemispheres at several time intervals during the execution of a Simon task. Suppression of the conflict between stimulus and response positions (i.e., the Simon effect) was found when TMS pulse was applied 130 msec after stimulus onset over the right AG and after 160 msec when applied over the left AG and SMG. Interestingly, only stimulation of the left SMG suppressed the asymmetry in conflict magnitude between left- and right-hand responses, usually observed in the Simon task. The present data show that orienting attention and motor attention processes are temporally, functionally, and spatially separated in the posterior parietal cortex, and both contribute to prime motor response during spatial conflict.

[1]  A. Cowey,et al.  The role of the parietal cortex in visual attention—hemispheric asymmetries and the effects of learning: a magnetic stimulation study , 1998, Neuropsychologia.

[2]  G. Rizzolatti,et al.  Reorienting attention across the horizontal and vertical meridians: Evidence in favor of a premotor theory of attention , 1987, Neuropsychologia.

[3]  Paul Cisek,et al.  Cortical mechanisms of action selection: the affordance competition hypothesis , 2007, Philosophical Transactions of the Royal Society B: Biological Sciences.

[4]  R. Passingham,et al.  Temporary interference in human lateral premotor cortex suggests dominance for the selection of movements. A study using transcranial magnetic stimulation. , 1998, Brain : a journal of neurology.

[5]  M. Zorzi,et al.  The role of long-term-memory and short-term-memory links in the Simon effect. , 2000, Journal of experimental psychology. Human perception and performance.

[6]  Alan Cowey,et al.  Cortical plasticity in perceptual learning demonstrated by transcranial magnetic stimulation , 1998, Neuropsychologia.

[7]  Jason B. Mattingley,et al.  Modality-Specific Control of Strategic Spatial Attention in Parietal Cortex , 2004, Neuron.

[8]  C. Umilta,et al.  The measurement of left—right asymmetries in the Simon effect: A fine-grained analysis , 2007, Behavior research methods.

[9]  Igor Schindler,et al.  An exploration of the role of the superior temporal gyrus in visual search and spatial perception using TMS , 2014 .

[10]  Tobias Egner,et al.  The neural correlates and functional integration of cognitive control in a Stroop task , 2005, NeuroImage.

[11]  C Iani,et al.  The Simon effect occurs relative to the direction of an attention shift. , 1997, Journal of experimental psychology. Human perception and performance.

[12]  E. Wassermann.  Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. , 1998, Electroencephalography and clinical neurophysiology.

[13]  John G. Kerns,et al.  Anterior cingulate and prefrontal cortex activity in an FMRI study of trial-to-trial adjustments on the Simon task , 2006, NeuroImage.

[14]  Alan Cowey,et al.  Transcranial magnetic stimulation and cognitive neuroscience , 2000, Nature Reviews Neuroscience.

[15]  S. Brandt,et al.  Executive control over response priming and conflict: a transcranial magnetic stimulation study , 2007, Experimental Brain Research.

[16]  R. Proctor,et al.  The influence of irrelevant location information on performance: A review of the Simon and spatial Stroop effects , 1995, Psychonomic bulletin & review.

[17]  Huifang Wang,et al.  Activation of response codes by relevant and irrelevant stimulus information , 1995 .

[18]  Carlo Umiltà,et al.  Differential effects of central and peripheral cues on the reorienting of spatial attention. , 1991 .

[19]  A. Schnitzler,et al.  Magnetic stimulation of the dorsal premotor cortex modulates the Simon effect. , 1999, Neuroreport.

[20]  J. R. Simon,et al.  Auditory S-R compatibility: the effect of an irrelevant cue on information processing. , 1967, The Journal of applied psychology.

[21]  Ryota Kanai,et al.  TMS of the FEF Interferes with Spatial Conflict , 2012, Journal of Cognitive Neuroscience.

[22]  J. Mattingley,et al.  Fast and slow parietal pathways mediate spatial attention , 2004, Nature Neuroscience.

[23]  M. Rushworth,et al.  TMS in the parietal cortex: Updating representations for attention and action , 2006, Neuropsychologia.

[24]  Sandro Rubichi,et al.  The Simon effect and handedness: Evidence for a dominant-hand attentional bias in spatial coding , 2006, Perception & psychophysics.

[25]  R. E Passingham,et al.  Cerebral dominance for action in the human brain: the selection of actions , 2001, Neuropsychologia.

[26]  Timothy Edward John Behrens,et al.  Connection patterns distinguish 3 regions of human parietal cortex. , 2006, Cerebral cortex.

[27]  M. Mesulam.  A cortical network for directed attention and unilateral neglect , 1981, Annals of neurology.

[28]  James L. McClelland,et al.  On the control of automatic processes: a parallel distributed processing account of the Stroop effect. , 1990, Psychological review.

[29]  Richard Ridderinkhof.  Micro- and macro-adjustments of task set: activation and suppression in conflict tasks , 2002, Psychological research.

[30]  G. Goldenberg.  Apraxia and the parietal lobes , 2009, Neuropsychologia.

[31]  A. Osman,et al.  Dimensional overlap: cognitive basis for stimulus-response compatibility--a model and taxonomy. , 1990, Psychological review.

[32]  P. Cisek.  A Remarkable Facilitating Effect of Parietal Damage , 2008, Neuron.

[33]  C. Umilta,et al.  Two orienting mechanisms in posterior parietal lobule: An rTMS study of the Simon and SNARC effects , 2007, Cognitive neuropsychology.

[34]  Richard S. J. Frackowiak,et al.  Functional localization of the system for visuospatial attention using positron emission tomography. , 1997, Brain : a journal of neurology.

[35]  Alan Cowey,et al.  Temporal aspects of visual search studied by transcranial magnetic stimulation , 1997, Neuropsychologia.

[36]  E. Lauber,et al.  Conditional and unconditional automaticity: a dual-process model of effects of spatial stimulus-response correspondence. , 1994, Journal of experimental psychology. Human perception and performance.

[37]  M. Corbetta,et al.  Control of goal-directed and stimulus-driven attention in the brain , 2002, Nature Reviews Neuroscience.

[38]  Jason B. Mattingley,et al.  Enhancement of visual selection during transient disruption of parietal cortex , 2006, Brain Research.

[39]  M. Rushworth,et al.  The left parietal and premotor cortices: motor attention and selection , 2003, NeuroImage.

[40]  R. Verleger,et al.  Validity and boundary conditions of automatic response activation in the Simon task. , 2001, Journal of experimental psychology. Human perception and performance.

[41]  Carlo Umiltà,et al.  Response selection and attention orienting: a computational model of Simon effect asymmetries. , 2009, Experimental psychology.

[42]  Christoph Stahl,et al.  Disentangling common and specific neural subprocesses of response inhibition , 2013, NeuroImage.

[43]  M. Goodale,et al.  Separate visual pathways for perception and action , 1992, Trends in Neurosciences.

[44]  F Fazio,et al.  Recovery from aphasia and neglect after subcortical stroke: neuropsychological and cerebral perfusion study. , 1988, Journal of neurology, neurosurgery, and psychiatry.

[45]  Tobias Egner,et al.  Separate conflict-specific cognitive control mechanisms in the human brain , 2007, NeuroImage.

[46]  Jason B. Mattingley,et al.  Motor role of human inferior parietal lobe revealed in unilateral neglect patients , 1998, Nature.

[47]  Roberto Nicoletti,et al.  Spatial stimulus-response compatibility. , 1990 .

[48]  Jonathan D. Cohen,et al.  Conflict monitoring and anterior cingulate cortex: an update , 2004, Trends in Cognitive Sciences.