Control of autoimmunity by naturally arising regulatory CD4+ T cells.

[1]  D. Gallina,et al.  Transfusions enriched for W3/25+ helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat , 2005, Diabetologia.

[2]  T. Nomura,et al.  Control of Regulatory T Cell Development by the Transcription Factor Foxp3 , 2002 .

[3]  Y. Belkaid,et al.  CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity , 2002, Nature.

[4]  A. Sharpe,et al.  B7/CD28-Dependent CD4+CD25+ Regulatory T Cells Are Essential Components of the Memory-Protective Immunity to Candida albicans1 , 2002, The Journal of Immunology.

[5]  A. Coutinho,et al.  Peripheral expansion of thymus‐derived regulatory cells in anti‐myelin basic protein T cell receptor transgenic mice , 2002, European journal of immunology.

[6]  Manuela Battaglia,et al.  Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells , 2002, The Journal of experimental medicine.

[7]  K. Wood,et al.  Cutting Edge: CD4+CD25+ Alloantigen-Specific Immunoregulatory Cells That Can Prevent CD8+ T Cell-Mediated Graft Rejection: Implications for Anti-CD154 Immunotherapy1 , 2002, The Journal of Immunology.

[8]  A. Freitas,et al.  Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers1 , 2002, The Journal of Immunology.

[9]  Mark S. Anderson,et al.  Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein , 2002, Science.

[10]  Alf Hamann,et al.  Expression of the integrin αEβ7 identifies unique subsets of CD25+ as well as CD25− regulatory T cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[11]  J. Lafaille,et al.  Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function , 2002, The Journal of experimental medicine.

[12]  H. Macdonald,et al.  The Early IL-4 Response to Leishmania major and the Resulting Th2 Cell Maturation Steering Progressive Disease in BALB/c Mice Are Subject to the Control of Regulatory CD4+CD25+ T Cells1 , 2002, The Journal of Immunology.

[13]  C. Fathman,et al.  The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR71 , 2002, The Journal of Immunology.

[14]  A. Sher,et al.  Bacteria-triggered CD4+ T Regulatory Cells Suppress Helicobacter hepaticus–induced Colitis , 2002, The Journal of experimental medicine.

[15]  David Klatzmann,et al.  CD4+CD25+ Immunoregulatory T Cells , 2002, The Journal of experimental medicine.

[16]  C. Fathman,et al.  Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation , 2002, The Journal of experimental medicine.

[17]  L. Cosmi,et al.  Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes , 2002, The Journal of experimental medicine.

[18]  R. Lechler,et al.  CD4+CD25+ T cells as immunoregulatory T cells in vitro , 2002, European journal of immunology.

[19]  T. Malek,et al.  CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. , 2002, Immunity.

[20]  A. Filipovich,et al.  Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome , 2002, Journal of medical genetics.

[21]  M. Papiernik,et al.  Modulation of Fas-Dependent Apoptosis: A Dynamic Process Controlling Both the Persistence and Death of CD4 Regulatory T Cells and Effector T Cells1 , 2002, The Journal of Immunology.

[22]  G. Schuler,et al.  Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells , 2002, The Journal of experimental medicine.

[23]  Ethan M. Shevach,et al.  CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness , 2002, The Journal of experimental medicine.

[24]  A. Enk,et al.  Infectious Tolerance , 2002, The Journal of experimental medicine.

[25]  L. Klein,et al.  Origin of regulatory T cells with known specificity for antigen , 2002, Nature Immunology.

[26]  Akemi Sakamoto,et al.  CD25+CD4+ T cells contribute to the control of memory CD8+ T cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[27]  H. Waldmann,et al.  Identification of Regulatory T Cells in Tolerated Allografts , 2002, The Journal of experimental medicine.

[28]  Ethan M. Shevach,et al.  CD4+CD25+ suppressor T cells: more questions than answers , 2002, Nature Reviews Immunology.

[29]  H. Waldmann,et al.  Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance1 , 2002, The Journal of Immunology.

[30]  A. Coutinho,et al.  Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[31]  B. Blazar,et al.  The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. , 2002, Blood.

[32]  J. Demengeot,et al.  CD25+CD4+ regulatory T cells suppress CD4+ T cell‐mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice , 2002 .

[33]  J. Miyazaki,et al.  Generation of CD4+CD25+ Regulatory T Cells from Autoreactive T Cells Simultaneously with Their Negative Selection in the Thymus and from Nonautoreactive T Cells by Endogenous TCR Expression1 , 2002, The Journal of Immunology.

[34]  Charles A. Janeway,et al.  Decoding the Patterns of Self and Nonself by the Innate Immune System , 2002, Science.

[35]  P. Matzinger.  The Danger Model: A Renewed Sense of Self , 2002, Science.

[36]  F. Finkelman,et al.  The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells. , 2002, Immunity.

[37]  David F. Richards,et al.  In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines , 2002, The Journal of experimental medicine.

[38]  D. Hudrisier,et al.  Preferential Recognition of Self Antigens Despite Normal Thymic Deletion of CD4+CD25+ Regulatory T Cells1 , 2002, The Journal of Immunology.

[39]  M. Byrne,et al.  CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. , 2002, Immunity.

[40]  R. Flavell,et al.  Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. , 2002, Immunity.

[41]  J. Shimizu,et al.  Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance , 2002, Nature Immunology.

[42]  M. Karim,et al.  CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses1 , 2002, The Journal of Immunology.

[43]  D. Zélénika,et al.  Regulatory T Cells Overexpress a Subset of Th2 Gene Transcripts1 , 2002, The Journal of Immunology.

[44]  L. Ignatowicz,et al.  Peptide Specificity of Thymic Selection of CD4+CD25+ T Cells , 2002, The Journal of Immunology.

[45]  M. Taniguchi,et al.  CD4(+)CD25(+) T-cell development is regulated by at least 2 distinct mechanisms. , 2002, Blood.

[46]  A. Rudensky,et al.  Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo , 2002, Nature Immunology.

[47]  H. Ochs,et al.  IPEX is a unique X-linked syndrome characterized by immune dysfunction, polyendocrinopathy, enteropathy, and a variety of autoimmune phenomena , 2001, Current opinion in pediatrics.

[48]  Varuna Aluvihare,et al.  B cells and professional APCs recruit regulatory T cells via CCL4 , 2001, Nature Immunology.

[49]  C. Benoist,et al.  Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes , 2001, Nature Immunology.

[50]  Y. Lei,et al.  Hyper Immunoglobulin E Response in Mice with Monoclonal Populations of B and T Lymphocytes 〉 , 2001, The Journal of experimental medicine.

[51]  R. Lechler,et al.  Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. , 2001, Blood.

[52]  L. Klein,et al.  Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self , 2001, Nature Immunology.

[53]  C. Fathman,et al.  CD4+CD25+ T Cells Facilitate the Induction of T Cell Anergy , 2001, The Journal of Immunology.

[54]  A. Iellem,et al.  Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells , 2001, The Journal of experimental medicine.

[55]  T. Schumacher,et al.  Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses , 2001, The Journal of experimental medicine.

[56]  W. Strober,et al.  Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β , 2001, The Journal of experimental medicine.

[57]  T. Laufer,et al.  Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells , 2001, The Journal of experimental medicine.

[58]  L. Adorini,et al.  Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance1 , 2001, The Journal of Immunology.

[59]  F. Powrie,et al.  Control of intestinal inflammation by regulatory T cells , 2001, Immunological reviews.

[60]  M. A. Curotto de Lafaille,et al.  Regulatory T cells in spontaneous autoimmune encephalomyelitis , 2001, Immunological reviews.

[61]  M. Roncarolo,et al.  Type 1 T regulatory cells , 2001, Immunological reviews.

[62]  D. Mason.  Some quantitative aspects of T‐cell repertoire selection: the requirement for regulatory T cells , 2001, Immunological reviews.

[63]  I. Caramalho,et al.  Regulatory T cells: the physiology of autoreactivity in dominant tolerance and “quality control” of immune responses , 2001, Immunological reviews.

[64]  H. Weiner,et al.  Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells , 2001, Immunological reviews.

[65]  Sayuri Yamazaki,et al.  Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance , 2001, Immunological reviews.

[66]  G. Freeman,et al.  CD4+CD25high Regulatory Cells in Human Peripheral Blood1 , 2001, The Journal of Immunology.

[67]  E. Shevach,et al.  Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells , 2001, The Journal of Immunology.

[68]  A. Khoruts,et al.  Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen1 , 2001, The Journal of Immunology.

[69]  S. Yamagiwa,et al.  A Role for TGF-β in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral Blood1 , 2001, The Journal of Immunology.

[70]  G. Schuler,et al.  Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood , 2001, The Journal of experimental medicine.

[71]  R. Noelle,et al.  Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade , 2001, The Journal of experimental medicine.

[72]  M. Roncarolo,et al.  Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function , 2001, The Journal of experimental medicine.

[73]  A. Enk,et al.  Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood , 2001, The Journal of experimental medicine.

[74]  T. Hünig,et al.  Control of T cell hyperactivation in IL‐2‐deficient mice by CD4+CD25– and CD4+CD25+ T cells: evidence for two distinct regulatory mechanisms , 2001, European journal of immunology.

[75]  D. Mason,et al.  Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activity in vitro , 2001, European journal of immunology.

[76]  M. Salmon,et al.  Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis‐prone population , 2001, European journal of immunology.

[77]  S. Sakaguchi.  Policing the regulators , 2001, Nature Immunology.

[78]  A. Naji,et al.  Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide , 2001, Nature Immunology.

[79]  F. Powrie,et al.  IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo1 , 2001, The Journal of Immunology.

[80]  H. Cantor,et al.  Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells. , 2001, Journal of autoimmunity.

[81]  Ana Cumano,et al.  CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-101 , 2001, The Journal of Immunology.

[82]  H. Kikutani,et al.  Increased T Cell Autoreactivity in the Absence of CD40-CD40 Ligand Interactions: A Role of CD40 in Regulatory T Cell Development1 , 2001, The Journal of Immunology.

[83]  S. Sakaguchi,et al.  Animal models of autoimmunity and their relevance to human diseases. , 2000, Current opinion in immunology.

[84]  A. Enk,et al.  Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells , 2000, The Journal of experimental medicine.

[85]  D. Mason,et al.  CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations1 , 2000, The Journal of Immunology.

[86]  R. Lechler,et al.  Anergic T Cells Inhibit the Antigen-Presenting Function of Dendritic Cells1 , 2000, The Journal of Immunology.

[87]  J. Shimizu,et al.  Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. , 2000, International immunology.

[88]  Fiona Powrie,et al.  Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation , 2000, The Journal of experimental medicine.

[89]  T. Mak,et al.  Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4 , 2000, The Journal of experimental medicine.

[90]  S. Antonarakis,et al.  The Autoimmune Regulator Protein Has Transcriptional Transactivating Properties and Interacts with the Common Coactivator CREB-binding Protein* , 2000, The Journal of Biological Chemistry.

[91]  H. Hall,et al.  CD4+CD25+ regulatory T cells down‐regulate co‐stimulatory molecules on antigen‐presenting cells , 2000, European journal of immunology.

[92]  S. Sakaguchi.  Regulatory T cells , 2000, Cell.

[93]  J. Lafaille,et al.  Repertoire Requirements of CD4+ T Cells That Prevent Spontaneous Autoimmune Encephalomyelitis1 , 2000, The Journal of Immunology.

[94]  J. Bluestone,et al.  B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. , 2000, Immunity.

[95]  A. Cumano,et al.  Regulatory CD4 T Cells Control the Size of the Peripheral Activated/Memory CD4 T Cell Compartment1 , 2000, The Journal of Immunology.

[96]  D. Mason,et al.  The third function of the thymus. , 2000, Immunology today.

[97]  H. von Boehmer,et al.  Anergy and suppression regulate CD4+ T cell responses to a self peptide , 2000, European journal of immunology.

[98]  Ethan M. Shevach,et al.  Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific , 2000, The Journal of Immunology.

[99]  Klaus-Armin Nave,et al.  Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells , 2000, Nature Medicine.

[100]  M. Bevan,et al.  Selecting and maintaining a diverse T-cell repertoire , 1999, Nature.

[101]  J. Shimizu,et al.  Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. , 1999, Journal of immunology.

[102]  Fiona Powrie,et al.  An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation , 1999, The Journal of experimental medicine.

[103]  T. Mak,et al.  Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. , 1999, Journal of immunology.

[104]  T. Fujita,et al.  Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. , 1999, Cancer research.

[105]  F. Otsuka,et al.  Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. , 1999, Journal of immunology.

[106]  S. Morse,et al.  Virus and autoimmunity: induction of autoimmune disease in mice by mouse T lymphotropic virus (MTLV) destroying CD4+ T cells. , 1999, Journal of immunology.

[107]  S. Antonarakis,et al.  Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla. , 1999, Biochemical and biophysical research communications.

[108]  D. Mason,et al.  Peripheral Autoantigen Induces Regulatory T Cells that Prevent Autoimmunity , 1999, The Journal of experimental medicine.

[109]  R. Lechler,et al.  Anergic T cells act as suppressor cells in vitro and in vivo , 1999, European journal of immunology.

[110]  D. Margulies,et al.  Post‐thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti‐H/K ATPase‐ reactive T cells , 1999, European journal of immunology.

[111]  D. Mason,et al.  Regulatory T Cells in the Control of Autoimmunity: the Essential Role of  Transforming Growth Factor β and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4+CD45RC− Cells and CD4+CD8− Thymocytes , 1999, The Journal of experimental medicine.

[112]  A. Rudensky,et al.  Requirement for diverse, low-abundance peptides in positive selection of T cells. , 1999, Science.

[113]  D. Mason,et al.  Control of immune pathology by regulatory T cells. , 1998, Current opinion in immunology.

[114]  D. Hanahan,et al.  Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity. , 1998, Current opinion in immunology.

[115]  M. Toda,et al.  Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. , 1998, International immunology.

[116]  S. Tonegawa,et al.  CD4+ T Cells Prevent Spontaneous Experimental Autoimmune Encephalomyelitis in Anti–Myelin Basic Protein T Cell Receptor Transgenic Mice , 1998, The Journal of experimental medicine.

[117]  J. Lafaille,et al.  Regulatory Cd4 Ϩ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein–specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis , 1998 .

[118]  F. Powrie,et al.  CD38+ CD45RBlow CD4+ T cells: a population of T cells with immune regulatory activities in vitro , 1998, European journal of immunology.

[119]  L. Chatenoud,et al.  Mature mainstream TCR alpha beta+CD4+ thymocytes expressing L-selectin mediate "active tolerance" in the nonobese diabetic mouse. , 1998, Journal of immunology.

[120]  W. van Eden,et al.  Anergic T cells actively suppress T cell responses via the antigen‐presenting cell , 1998, European journal of immunology.

[121]  D. Mason,et al.  A very high level of crossreactivity is an essential feature of the T-cell receptor. , 1998, Immunology today.

[122]  Ethan M. Shevach,et al.  CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production , 1998, The Journal of experimental medicine.

[123]  D. Gautheret,et al.  Quantitative Analysis of the T Cell Repertoire Selected by a Single Peptide–Major Histocompatibility Complex , 1998, The Journal of experimental medicine.

[124]  R. Houghten,et al.  Probing degeneracy in T-cell recognition using peptide combinatorial libraries. , 1998, Immunology today.

[125]  C. Pénit,et al.  Regulatory Cd4 T Cells: Expression of Il-2rα Chain, Resistance to Clonal Deletion and Il-2 Dependency , 1998 .

[126]  C. Benoist,et al.  Major Histocompatibility Complex Class II Molecules Can Protect from Diabetes by Positively Selecting T Cells with Additional Specificities , 1998, The Journal of experimental medicine.

[127]  E. Shevach,et al.  CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. , 1998, Journal of immunology.

[128]  H. Waldmann,et al.  How do monoclonal antibodies induce tolerance? A role for infectious tolerance? , 1998, Annual review of immunology.

[129]  J. Allison,et al.  The emerging role of CTLA-4 as an immune attenuator. , 1997, Immunity.

[130]  Hervé Groux,et al.  A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis , 1997, Nature.

[131]  Kathleen M. Smith,et al.  Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance. , 1997, International immunology.

[132]  M. Bevan,et al.  In thymic selection, peptide diversity gives and takes away. , 1997, Immunity.

[133]  J. Bluestone.  Is CTLA-4 a master switch for peripheral T cell tolerance? , 1997, Journal of immunology.

[134]  Shinsei Minoshima,et al.  Positional cloning of the APECED gene , 1997, Nature Genetics.

[135]  D. Mason,et al.  The Thymus Contains a High Frequency of Cells that Prevent Autoimmune Diabetes on Transfer into Prediabetic Recipients , 1996, The Journal of experimental medicine.

[136]  P. Pereira,et al.  Establishment of tissue‐specific tolerance is driven by regulatory T cells selected by thymic epithelium , 1996, European journal of immunology.

[137]  S. Sakaguchi,et al.  Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation , 1996, The Journal of experimental medicine.

[138]  R. Coffman,et al.  A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells , 1996, The Journal of experimental medicine.

[139]  S. Morse,et al.  T cell-mediated maintenance of natural self-tolerance: its breakdown as a possible cause of various autoimmune diseases. , 1996, Journal of autoimmunity.

[140]  A. Coutinho,et al.  Evidence for a Thymus‐Dependent Form of Tolerance that is Not Based on Elimination or Anergy of Reactive T cells , 1996, Immunological reviews.

[141]  A. Coutinho,et al.  A Model for Developmentally Acquired Thymus‐Dependent Tolerance to Central and Peripheral Antigens , 1996, Immunological reviews.

[142]  P. Gleeson,et al.  Organ‐specific Autoimmunity Induced by Lymphopenia , 1996, Immunological reviews.

[143]  H. Wekerle,et al.  The Shaping of the Brain–Specific T Lymphocyte Repertoire in the Thymus , 1996, Immunological reviews.

[144]  H. Griesser,et al.  Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4 , 1995, Science.

[145]  J. Bluestone,et al.  Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. , 1995, Immunity.

[146]  F. Alt,et al.  Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. , 1995, Immunity.

[147]  P. Pereira,et al.  Regulatory T cells in thymic epithelium‐induced tolerance. I. Suppression of mature peripheral non‐tolerant T cells , 1995, European journal of immunology.

[148]  M. Toda,et al.  Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.

[149]  A. Coutinho,et al.  Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[150]  H. Griesser,et al.  Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. , 1995, Science.

[151]  P. Gleeson,et al.  Organ‐specific autoimmunity induced by adult thymectomy and cyclophosphamide‐induced lymphopenia , 1995, European journal of immunology.

[152]  H. Weiner,et al.  Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. , 1994, Science.

[153]  Susumu Tonegawa,et al.  High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice , 1994, Cell.

[154]  M. Takeuchi,et al.  Tissue-specific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens. , 1994, Immunology.

[155]  R. Lechler,et al.  Anergic T cells as suppressor cells in vitro. , 1994, Science.

[156]  P. A. Peterson,et al.  Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression. , 1994, Journal of immunology.

[157]  G. J. V. Nossal,et al.  Negative selection of lymphocytes , 1994, Cell.

[158]  S. Sakaguchi,et al.  Ionizing radiation and autoimmunity. Induction of autoimmune disease in mice by high dose fractionated total lymphoid irradiation and its prevention by inoculating normal T cells. , 1992, Journal of immunology.

[159]  P. Bruggen,et al.  Tumor antigens recognized by T lymphocytes. , 1994, Annual review of immunology.

[160]  R. Coffman,et al.  Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. , 1993, International immunology.

[161]  K. Rajewsky,et al.  Interleukin-10-deficient mice develop chronic enterocolitis , 1993, Cell.

[162]  J. Watson,et al.  CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells , 1993, The Journal of experimental medicine.

[163]  W. Heath,et al.  Self‐Ignorance in the Peripheral T‐Cell Pool , 1993, Immunological reviews.

[164]  D. Mason,et al.  Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential , 1993, The Journal of experimental medicine.

[165]  D. Kioussis,et al.  "Infectious" transplantation tolerance , 1993, Science.

[166]  M. Sporn,et al.  Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[167]  A. Coutinho,et al.  Autoimmunity : physiology and disease , 1993 .

[168]  G. Proetzel,et al.  Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease , 1992, Nature.

[169]  K. Kuribayashi,et al.  Germ-free condition and the susceptibility of BALB/c mice to post-thymectomy autoimmune gastritis. , 1992, Autoimmunity.

[170]  I. Horak,et al.  Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting , 1991, Nature.

[171]  H. Pircher,et al.  Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice , 1991, Cell.

[172]  B. Rocha,et al.  Peripheral selection of the T cell repertoire. , 1991, Science.

[173]  J. Sprent,et al.  Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity , 1990, Cell.

[174]  D. Longo,et al.  Peripheral clonal elimination of functional T cells. , 1990, Science.

[175]  P. Mccullagh.  Curtailment of autoimmunity following parabiosis with a normal partner. , 1990, Immunology.

[176]  D. Mason,et al.  OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset [published erratum appears in J Exp Med 1991 Apr 1;173(4):1037] , 1990, The Journal of experimental medicine.

[177]  S. Sakaguchi,et al.  Thymus and autoimmunity: capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune disease , 1990, The Journal of experimental medicine.

[178]  Y. Kohno,et al.  Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. III. Analysis of regulatory cells suppressing the induction of thyroiditis. , 1990, International immunology.

[179]  A. Coutinho,et al.  Thymic epithelium tolerizes for histocompatibility antigens. , 1990, Science.

[180]  J. Roberts,et al.  Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities , 1990, The Journal of experimental medicine.

[181]  R. Flavell,et al.  T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E , 1989, Nature.

[182]  F. Ramsdell,et al.  A nondeletional mechanism of thymic self tolerance. , 1989, Science.

[183]  P. Mccullagh.  Interception of the development of self tolerance in fetal lambs , 1989, European journal of immunology.

[184]  H. Rammensee,et al.  Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells , 1989, Nature.

[185]  C. Boitard,et al.  T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice , 1989, The Journal of experimental medicine.

[186]  S. Sakaguchi,et al.  Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease. , 1989, Journal of immunology.

[187]  Y. Kohno,et al.  Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. I. Requirement of Lyt-1 dull L3T4 bright normal T cells for the induction of thyroiditis. , 1988, Journal of immunology.

[188]  H. Boehmer,et al.  Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes , 1988, Nature.

[189]  C. Corbel,et al.  Tolerance induced by thymic epithelial grafts in birds. , 1987, Science.

[190]  D. Greiner,et al.  Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats , 1987, The Journal of experimental medicine.

[191]  P. Marrack,et al.  T cell tolerance by clonal elimination in the thymus , 1987, Cell.

[192]  Y. Nishizuka,et al.  Self tolerance and localized autoimmunity. Mouse models of autoimmune disease that suggest tissue-specific suppressor T cells are involved in self tolerance , 1987, The Journal of experimental medicine.

[193]  S. Sakaguchi,et al.  Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease , 1985, The Journal of experimental medicine.

[194]  T. Takahashi,et al.  Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis , 1982, The Journal of experimental medicine.

[195]  S. Sakaguchi,et al.  Study on cellular events in postthymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocytes damage after adoptive transfer , 1982, The Journal of experimental medicine.

[196]  R. Prehn,et al.  Genetic susceptibility to post-thymectomy autoimmune diseases in mice , 1981, Immunogenetics.

[197]  T. Sakakura,et al.  Autoimmune oophoritis in thymectomized mice: detection of circulating antibodies against oocytes. , 1980, Clinical and experimental immunology.

[198]  Y. Nishizuka,et al.  Experimental production of possible autoimmune castritis followed by macrocytic anemia in athymic nude mice. , 1980, Laboratory investigation; a journal of technical methods and pathology.

[199]  W. Weigle.  Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. , 1980, Advances in immunology.

[200]  T. Sakakura,et al.  Spontaneous development of autoimmune thyroiditis in neonatally thymectomized mice. , 1976, Laboratory investigation; a journal of technical methods and pathology.

[201]  W. Irvine,et al.  Spontaneous thyroiditis in thymectomized and irradiated Wistar rats. , 1973, Clinical and experimental immunology.

[202]  T. Sakakura,et al.  Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice , 1969, Science.

[203]  J. Lederberg.  Genes and antibodies. , 1959, Science.

[204]  F. Burnet.  The clonal selection theory of acquired immunity , 1959 .