Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506.

[1]  K. Fukasawa,et al.  Sequence‐selective DNA cleavage by a topoisomerase I poison, NB‐506 , 1998, International journal of cancer.

[2]  H. Kawamoto,et al.  Synthesis of NB-506, A new anticancer agent , 1997 .

[3]  S. Morham,et al.  Targeted disruption of the mouse topoisomerase I gene by camptothecin selection , 1996, Molecular and cellular biology.

[4]  S. Nishimura,et al.  Novel antitumor indolocarbazole compound 6-N-formylamino-12,13-dihydro-1,11- dihydroxy-13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4- c]carbazole-5,7(6H)-dione (NB-506): induction of topoisomerase I-mediated DNA cleavage and mechanisms of cell line-selective cytotoxicity. , 1995, Cancer research.

[5]  S. Nishimura,et al.  Novel indolocarbazole compound 6-N-formylamino-12,13-dihydro-1,11-dihydroxy- 13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo-[3,4-c]carbazole- 5,7(6H)-dione (NB-506): its potent antitumor activities in mice. , 1995, Cancer research.

[6]  J. Mohler,et al.  Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy. , 1994, Cancer research.

[7]  H. Suda,et al.  Induction of topoisomerase I-mediated DNA cleavage by a new indolocarbazole, ED-110. , 1993, Cancer research.

[8]  H. Suda,et al.  A new indolopyrrolocarbazole antitumor substance, ED-110, a derivative of BE-13793C. , 1992, The Journal of antibiotics.

[9]  M. Okanishi,et al.  A new antitumor substance BE-13793C, produced by a streptomycete. Taxonomy, fermentation, isolation, structure determination and biological activity. , 1991, The Journal of antibiotics.

[10]  Leroy F. Liu,et al.  Transcription generates positively and negatively supercoiled domains in the template , 1988, Cell.

[11]  G. Schütz,et al.  Camptothecin-induced in vivo topoisomerase I cleavages in the transcriptionally active tyrosine aminotransferase gene , 1987, Cell.