Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer’s disease

[1]  K. Blennow,et al.  Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease. , 2019, JAMA neurology.

[2]  N. Greig,et al.  Neuronal Enriched Extracellular Vesicle Proteins as Biomarkers for Traumatic Brain Injury. , 2019, Journal of neurotrauma.

[3]  A. Gabelle,et al.  HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links? , 2018, Front. Cell. Neurosci..

[4]  K. Blennow,et al.  Neurofilament light chain in blood is negatively associated with neuropsychological performance in HIV-infected adults and declines with initiation of antiretroviral therapy , 2018, Journal of NeuroVirology.

[5]  E. Abner,et al.  Deficient neurotrophic factors of CSPG4‐type neural cell exosomes in Alzheimer disease , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[6]  R. Stern,et al.  Higher exosomal tau, amyloid-beta 42 and IL-10 are associated with mild TBIs and chronic symptoms in military personnel , 2018, Brain injury.

[7]  L. Lannfelt,et al.  Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers , 2018, Acta Neuropathologica.

[8]  A. Puccio,et al.  Exosomes in Acquired Neurological Disorders: New Insights into Pathophysiology and Treatment , 2018, Molecular Neurobiology.

[9]  P. Martinelli,et al.  The CSF neurofilament light signature in rapidly progressive neurodegenerative dementias , 2018, Alzheimer's Research & Therapy.

[10]  G. Jicha,et al.  Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer's disease , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[11]  M. Mattson,et al.  In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellular vesicles , 2017, Aging cell.

[12]  L. Pulliam,et al.  Blood neuron-derived exosomes as biomarkers of cognitive impairment in HIV , 2017, AIDS.

[13]  K. Blennow,et al.  Plasma and cerebrospinal fluid tau and neurofilament concentrations in rapidly progressive neurological syndromes: a neuropathology‐based cohort , 2017, European journal of neurology.

[14]  E. Peskind,et al.  Biofluid biomarkers of traumatic brain injury , 2017, Brain injury.

[15]  K. Blennow,et al.  Neurofilament light chain protein as a marker of neuronal injury: review of its use in HIV-1 infection and reference values for HIV-negative controls , 2017, Expert review of molecular diagnostics.

[16]  E. Goetzl,et al.  Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes , 2017, Front. Neurosci..

[17]  A. Granholm,et al.  Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome , 2017, Alzheimer's & Dementia.

[18]  Alzheimer's Disease Neuroimaging Initiative.  Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease , 2017 .

[19]  Henrik Zetterberg,et al.  Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease , 2017, JAMA neurology.

[20]  Lu Yang,et al.  Emerging roles of extracellular vesicles in neurodegenerative disorders: focus on HIV-associated neurological complications , 2016, Cell Death and Disease.

[21]  Roland Eils,et al.  Complex heatmaps reveal patterns and correlations in multidimensional genomic data , 2016, Bioinform..

[22]  G. Jicha,et al.  Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease , 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  L. Pulliam,et al.  Monocyte exosomes induce adhesion molecules and cytokines via activation of NF‐κB in endothelial cells , 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[24]  D. Galasko,et al.  Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile , 2016, Alzheimer's & dementia.

[25]  J. Trojanowski,et al.  Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging , 2016, Annals of clinical and translational neurology.

[26]  C. Théry,et al.  Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes , 2016, Proceedings of the National Academy of Sciences.

[27]  K. Blennow,et al.  Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study , 2015, EBioMedicine.

[28]  Sagar H. Barage,et al.  Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease , 2015, Neuropeptides.

[29]  R. Petersen,et al.  Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease , 2015, Neurology.

[30]  R. Petersen,et al.  Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study , 2015, Alzheimer's & Dementia.

[31]  R. Petersen,et al.  Low neural exosomal levels of cellular survival factors in Alzheimer’s disease , 2015, Annals of clinical and translational neurology.

[32]  R. Petersen,et al.  Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural‐derived blood exosomes of preclinical Alzheimer's disease , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[33]  C. Yiannoutsos,et al.  Cerebrospinal Fluid (CSF) Neuronal Biomarkers across the Spectrum of HIV Infection: Hierarchy of Injury and Detection , 2014, PloS one.

[34]  B. Vissel,et al.  Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease , 2014, Acta neuropathologica communications.

[35]  L. Pulliam,et al.  Exosomes as mediators of neuroinflammation , 2014, Journal of Neuroinflammation.

[36]  A. Hill,et al.  Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases? , 2012, Front. Physio..

[37]  E. Masliah,et al.  Increased Accumulation of Intraneuronal Amyloid β in HIV-Infected Patients , 2009, Journal of Neuroimmune Pharmacology.

[38]  E. Masliah,et al.  Brain deposition of beta-amyloid is a common pathologic feature in HIV positive patients , 2005, AIDS.

[39]  Lynn Pulliam,et al.  HIV-1 Tat inhibits neprilysin and elevates amyloid β , 2005 .

[40]  L. Pulliam,et al.  P3-371 HIV-1 TAT inhibits neprilysin and elevates amyloid beta , 2004, Neurobiology of Aging.

[41]  N. Norgren,et al.  Elevated neurofilament levels in neurological diseases , 2003, Brain Research.

[42]  G. Broggi,et al.  Efficacy of ‘8-drugs-in-one-day’ combination in treatment of recurrent GBM patients , 1992, Journal of Neuro-Oncology.

[43]  A. Wallin,et al.  Differential Impact of Neurofilament Light Subunit on Cognition and Functional Outcome in Memory Clinic Patients with and without Vascular Burden. , 2015, Journal of Alzheimer's disease : JAD.

[44]  L. Hersh,et al.  Tat peptides inhibit neprilysin , 2011, Journal of NeuroVirology.

[45]  J. Hardy,et al.  The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics , 2009 .