Low-Molecular-Weight Dextran

Toxic reactions to currently employed iodinated water-soluble radiopaque media have been responsible for the occurrence of considerable morbidity and some deaths after such diagnostic procedures as cardioangiography, aortography, arteriography, and pyelography. 7, 12, 23 The mechanism of these reactions has been the subject of intense clinical interest for some time. However, until quite recently, no satisfactory explanation for many of the observed clinical and experimental reactions had been advanced. 21 The role of allergic phenomena has been seriously challenged by Sandstrom, 26 who clearly indicates that there is no evidence for the value of pretesting or prophylaxis, history of previous contact, or proof of antigen-antibody reaction. Other authors agree that pretesting and prophylactic antihistaminics are of little value in predicting or preventing these reactions. 12 Recent studies by Read 24 have demonstrated that the phenomenon of diffuse intravascular red-blood-cell sludging occurs after the intravenous injection of a number of hypertonic

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[3]  R. Read,et al.  Cause of death in cardioangiography. , 1959, The Journal of thoracic and cardiovascular surgery.

[4]  J. O. Hoppe.  SOME PHARMACOLOGICAL ASPECTS OF RADIOPAQUE COMPOUNDS , 1959, Annals of the New York Academy of Sciences.

[5]  J. Ditzel.  Relationship of blood protein composition to intravascular erythrocyte aggregation (sludged blood); clinical and experimental studies. , 1959, Acta medica Scandinavica. Supplementum.

[6]  E. Bernstein,et al.  Intravenous abdominal aortography; a preliminary report. , 1958, Surgery.

[7]  S. I. Askovitz,et al.  Reactions associated with intravenous urography: historical and statistical review. , 1958, Radiology.

[8]  L. Gelin.  Intravascular aggregation and capillary flow. , 1957, Acta chirurgica Scandinavica.

[9]  G. Rowe,et al.  The Physiologic Effect of Contrast Media Used for Angiocardiography , 1956, Circulation.

[10]  L. Gelin.  Studies in anemia of injury. , 1956, Acta chirurgica Scandinavica. Supplementum.

[11]  Bigelow Wg,et al.  Intravascular agglutination of erythrocytes (sludged blood) and traumatic shock. , 1950 .

[12]  R. Heimbecker,et al.  Intravascular agglutination (sludged blood) vascular stasis and sedimentation rate of blood in trauma. , 1949, Archives of surgery.

[13]  M. H. Knisely,et al.  Sludged blood in traumatic shock; microscopic observations of the precipitation and agglutination of blood flowing through vessels in crushed tissues. , 1945, Archives of surgery.