A Study of the Bisphosphonic Derivatives from the Pudovik Reaction of Dialkyl α-Oxophosphonates and >P(O)H Reagents: X-ray Structure and Bioactivity
暂无分享,去创建一个
G. Keglevich | S. Bősze | L. Drahos | M. Czugler | K. Karaghiosoff | Zsuzsanna Szalai | Boldizsár Tóth | Rita Oláhné Szabó
[1] G. Keglevich,et al. Tetraalkyl Hydroxymethylene-bisphosphonate and Dialkyl 1-Diphenylphosphinoyl-1-hydroxy-ethylphosphonate Derivatives by the Pudovik Reaction and Their Rearranged Products , 2021, Molecules.
[2] S. Bősze,et al. The grass root endophytic fungus Flavomyces fulophazii: An abundant source of tetramic acid and chlorinated azaphilone derivatives. , 2021, Phytochemistry.
[3] G. Keglevich,et al. The surprising diacylation of diethyl (ethoxycarbonylmethyl)phosphonate , 2021 .
[4] H. Raja,et al. Apoptotic activity of xanthoquinodin JBIR-99, from Parengyodontium album MEXU 30054, in PC-3 human prostate cancer cells. , 2019, Chemico-biological interactions.
[5] G. Keglevich,et al. A Study on the Synthesis of Risedronic Acid: The Role of an Ionic Liquid Additive , 2019, Letters in Drug Design & Discovery.
[6] G. Keglevich,et al. Efficient syntheses of zoledronic acid as an active ingredient of a drug against osteoporosis , 2018 .
[7] G. Keglevich,et al. Efficient Synthesis of Ibandronate in the Presence of an Ionic Liquid , 2017, Letters in Drug Design & Discovery.
[8] G. Keglevich,et al. The Role of Phosphorus Trichloride and Phosphorous Acid in the Formation of α-Hydroxymethylenebisphosphonic Acids from the Corresponding Carboxylic Acids – A Mechanistic Overview , 2017 .
[9] G. Keglevich,et al. Investigation of the effect of medium in the preparation of alendronate: till now the best synthesis in the presence of an ionic liquid additive , 2017 .
[10] G. Keglevich,et al. Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents , 2016, Molecules.
[11] G. Keglevich,et al. Solid-Liquid Phase C-Alkylation of Active Methylene Containing Compounds under Microwave Conditions , 2015 .
[12] I. Greiner,et al. “Greener” Synthesis of Bisphosphonic/Dronic Acid Derivatives. , 2014 .
[13] G. Keglevich,et al. “Greener” synthesis of bisphosphonic/dronic acid derivatives , 2014 .
[14] G. Keglevich,et al. Rational Synthesis of Ibandronate and Alendronate , 2013 .
[15] G. Keglevich,et al. N-heterocyclic dronic acids: applications and synthesis. , 2012, Mini reviews in medicinal chemistry.
[16] G. Keglevich,et al. Phenyl‐, benzyl‐, and unsymmetrical hydroxy‐methylenebisphosphonates as dronic acid ester analogues from α‐oxophosphonates by microwave‐assisted syntheses , 2011 .
[17] Łukasz Berlicki,et al. Remarkable potential of the α-aminophosphonate/phosphinate structural motif in medicinal chemistry. , 2011, Journal of medicinal chemistry.
[18] G. Keglevich,et al. Optimized synthesis of N-heterocyclic dronic acids; closing a black-box era , 2011 .
[19] I. Molnár,et al. Synthesis of α-Hydroxy-methylenebisphosphonates by the Microwave-Assisted Reaction of α-Oxophosphonates and Dialkyl Phosphites under Solventless Conditions. , 2010 .
[20] S. Uhlig,et al. Potent and selective inhibition of acid sphingomyelinase by bisphosphonates. , 2009, Angewandte Chemie.
[21] C. Ganellin,et al. Analogue-based Drug Discovery: FISCHER: ANALOGUE-BASED DRUG DISCOVERY O-BK , 2006 .
[22] E. Breuer. The Development of Bisphosphonates as Drugs , 2006 .
[23] T. Cierpicki,et al. The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity. , 2003, Journal of medicinal chemistry.
[24] F. Cotton,et al. Metal Salts and Complexes of Dialkoxyphosphonylacetylmethanide Ions , 2002 .
[25] T. Järvinen,et al. Bisphosphonate Prodrugs. Selective Synthesis of (1-Hydroxyethylidene)-1,1-bisphosphonate Partial Esters , 2001 .
[26] T. Järvinen,et al. BISPHOSPHONATE PRODRUGS. SYNTHESIS AND IDENTIFICATION OF (1-HYDROXYETHYLIDENE)-1,1-BISPHOSPHONIC ACID TETRAESTERS BY MASS SPECTROMETRY, NMR SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY , 2001 .
[27] J. Yokota,et al. Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes. , 1999, International journal of oncology.
[28] F. Richter,et al. ZUR SYNTHESE UND REAKTIVITT METHYLENVERBRCKTER DIPHOSPHORYLVERBINDUNGEN , 1992 .
[29] 에스코 포후얄라,et al. Novel methylenebisphosphonic acid derivatives , 1991 .
[30] E. Niesor,et al. gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity. , 1987, Journal of medicinal chemistry.
[31] A. Tromelin,et al. α CÉTOPHOSPHONATES ET ESTERS CYCLIQUES D'HYDROXYMÉTHYLÈNES DIPHOSPHONATES SYNTHESES, STRUCTURES ET HYDROLYSE , 1986 .
[32] F. Denizot,et al. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. , 1986, Journal of immunological methods.
[33] T. Mosmann. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.
[34] J. Lechner,et al. Establishment and characterization of a human prostatic carcinoma cell line (PC-3). , 1979, Investigative urology.
[35] M. Olivé,et al. Long-term human breast carcinoma cell lines of metastatic origin: Preliminary characterization , 1978, In Vitro.
[36] S. Singer,et al. Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A-431. , 1978, Proceedings of the National Academy of Sciences of the United States of America.
[37] D. Nicholson,et al. A General Method of Preparation of Tetramethyl Alkyl-1-hydroxy-1,1-diphosphonates , 1971 .
[38] T. J. Logan,et al. gem-Diphosphinoalkanes. Preparation and Characterization , 1966 .
[39] K. Moedritzer,et al. N.m.r. Study of the P-C(OH)-P to P-C-O-P Rearrangement: Tetraethyl 1-Hydroxyalkylidenediphosphonates , 1962 .
[40] G. M. Kosolapoff. The Chemistry of Aliphatic Phosphonic Acids. I. Alkylation of Methanediphosphonic Acid1 , 1953 .
[41] G. Keglevich,et al. Solid–liquid two-phase alkylation of tetraethyl methylenebisphosphonate under microwave irradiation , 2011 .
[42] G. Keglevich,et al. Synthesis of α-hydroxy-methylenebisphos-phonates by the microwave-assisted reaction of α-oxophosphonates and dialkyl phosphites under solventless conditions , 2009 .