EVALUATION OF ANXIOLYTIC EFFECT OF PET-ETHER EXTRACT OF PORTULACA OLERACEA (LINN.) IN MICE

The usage of benzodiazepines, the major class of anxiolytic drugs is invariably accompanied by many side effects like sedation and myorelaxation leading to incoordination of movements. Intense research is going on all over the world to find out most effective and safer anxiolytic compounds. In the present study, portilaca oleracea has been investigated in detail for its anxiolytic in mice. The anxiolytic activity was screened by using two well validated methods namely elevated plus maze, stair case test. Portilaca oleracea displayed a dose-dependent anxiolytic effect similar to diazepam in the animal models of anxiety as revealed by a significant increase in the time spent in open arms of the elevated plus maze and significant reduction in the number of rearing responses in staircase test, the results of the present study have identified the novel anxiolytic compound. Keywords: Portulaca oleracea (Linn.), petroleum-ether extract, Anxiolytic activity, Diazepam

[1]  Publisher Dr.B.P.Reddy.  International Journal of Applied Biology and Pharmaceutical Technology , 2014 .

[2]  C. Wiener.  Harrison's principles of internal medicine , 2013 .

[3]  J. Barbosa-Filho,et al.  Sources of alpha-, beta-, gamma-, delta- and epsilon-carotenes: a twentieth century review , 2008 .

[4]  D. Moser,et al.  "The rust of life": impact of anxiety on cardiac patients. , 2007, American journal of critical care : an official publication, American Association of Critical-Care Nurses.

[5]  Sebastian P Fernandez,et al.  Central nervous system depressant action of flavonoid glycosides. , 2006, European journal of pharmacology.

[6]  H. Xue,et al.  Neuroactive flavonoids interacting with GABAA receptor complex. , 2005, Current drug targets. CNS and neurological disorders.

[7]  John F. Cryan,et al.  Model organisms: The ascent of mouse: advances in modelling human depression and anxiety , 2005, Nature Reviews Drug Discovery.

[8]  A. Paladini,et al.  GABA(A)-receptor ligands of flavonoid structure. , 2002, Current topics in medicinal chemistry.

[9]  C. Hocart,et al.  Fatty acids and β-carotene in Australian purslane (Portulaca oleracea) varieties , 2000 .

[10]  K. Oh,et al.  Detection of antifungal activity in Portulaca oleracea by a single‐cell bioassay system , 2000, Phytotherapy research : PTR.

[11]  J. Medina,et al.  Flavonoids and the Central Nervous System: from Forgotten Factors to Potent Anxiolytic Compounds , 1999, The Journal of pharmacy and pharmacology.

[12]  Y. Hashidoko,et al.  Factors responsible for inhibiting the motility of zoospores of the phytopathogenic fungus Aphanomyces cochlioides isolated from the non‐host plant Portulaca oleracea , 1998, FEBS letters.

[13]  S. Bhattacharya,et al.  Experimental methods for evaluation of psychotropic agents in rodents: I--Anti-anxiety agents. , 1997, Indian journal of experimental biology.

[14]  N. Sakai,et al.  Portuloside A, a monoterpene glucoside, from Portulaca oleracea , 1996 .

[15]  J. A. Marks,et al.  The skeletal muscle relaxant action of Portulaca oleracea: role of potassium ions. , 1993, Journal of ethnopharmacology.

[16]  A. Simopoulos,et al.  Common purslane: a source of omega-3 fatty acids and antioxidants. , 1992, Journal of the American College of Nutrition.

[17]  J H Medina,et al.  Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties. , 1990, Biochemical pharmacology.

[18]  S. Chatterjee,et al.  Antifertility effects of common edible Portulaca oleracea on the reproductive organs of male albino mice. , 1982, The Indian journal of medical research.

[19]  S. Bhattacharya,et al.  Erythrina--chemical and pharmacological evaluation II: alkaloids of Erythrina variegata L. , 1972, Journal of pharmaceutical sciences.

[20]  N. J. Rao,et al.  EVALUATION OF ANTI ARTHRITIC ACTIVITY OF PET – ETHER EXTRACT OF PORTULACA OLERACEA (Linn.) , 2012 .

[21]  Evaluation of the Anti-nociceptive and Anti-inflammatory Activities of the Pet: Ether Extract of Portulaca Oleracea (Linn.) , 2012 .

[22]  Kr Khandelwal,et al.  Practical pharmacognosy techniques and experiments , 2008 .

[23]  J. Simiand,et al.  The staircase test in mice: A simple and efficient procedure for primary screening of anxiolytic agents , 2004, Psychopharmacology.

[24]  M. Ezekwe,et al.  Nutritive characterization of purslane accessions as influenced by planting date , 1999, Plant foods for human nutrition.