Charcot Neuropathic Arthropathy of the Foot: A Literature Review and Single-Center Experience

Charcot neuropathic osteoarthropathy of the foot is a relatively common complication of diabetic neuropathy. Incorrect diagnosis and improper treatment often result in the extremity having to be amputated. This paper summarises the current view on the etiology, diagnostics, and treatment of diabetic Charcot neuropathic osteoarthropathy, with particular focus on preserving the extremity through surgical intervention from our own experiences.

[1]  T. Chung,et al.  Risk factors of diabetic foot Charcot arthropathy: a case-control study at a Malaysian tertiary care centre. , 2016, Singapore medical journal.

[2]  R. Springfeld,et al.  German-Austrian consensus on operative treatment of Charcot neuroarthropathy: a Perspective by the Charcot task force of the German Association for Foot Surgery , 2011, Diabetic foot & ankle.

[3]  R. Frykberg,et al.  Mortality Risk of Charcot Arthropathy Compared With That of Diabetic Foot Ulcer and Diabetes Alone , 2009, Diabetes Care.

[4]  P. Lazzarini,et al.  Developing an evidence-based clinical pathway for the assessment, diagnosis and management of acute Charcot Neuro-Arthropathy: a systematic review , 2013, Journal of Foot and Ankle Research.

[5]  G. P. Kozak,et al.  Neuro-osteoarthropathy (Charcot's joint) in diabetes mellitus following revascularization surgery. Three case reports and a review of the literature. , 1987, Archives of internal medicine.

[6]  Benjamin A Lipsky,et al.  Osteomyelitis or Charcot neuro-osteoarthropathy? Differentiating these disorders in diabetic patients with a foot problem , 2013, Diabetic foot & ankle.

[7]  W. R. Jordan NEURITIC MANIFESTATIONS IN DIABETES MELLITUS , 1936 .

[8]  R. Jenkins,et al.  Charcot neuroarthropathy in diabetes mellitus , 2002, Diabetologia.

[9]  W. Peh,et al.  Magnetic resonance imaging of diabetic foot complications. , 2015, Singapore medical journal.

[10]  M. Assal,et al.  Realignment and extended fusion with use of a medial column screw for midfoot deformities secondary to diabetic neuropathy. , 2009, The Journal of bone and joint surgery. American volume.

[11]  Eva L Feldman,et al.  Diabetic neuropathy: clinical manifestations and current treatments , 2012, The Lancet Neurology.

[12]  Lee C. Rogers,et al.  The Charcot Foot in Diabetes , 2011, Diabetes Care.

[13]  J. Mitchell On a New Practice in Acute and Chronic Rheumatism , 1831, The London medical and physical journal.

[14]  C. Combescure,et al.  Miniaturized Oligonucleotide Arrays , 2007, Diabetes Care.

[15]  David A. Hanauer,et al.  Data Mining for Identifying Novel Associations and Temporal Relationships with Charcot Foot , 2014, Journal of diabetes research.

[16]  T. Mittlmeier,et al.  Intramedullary medial column support with the Midfoot Fusion Bolt (MFB) is not sufficient for osseous healing of arthrodesis in neuroosteoarthropathic feet. , 2014, Injury.

[17]  A. Sämann,et al.  Diabetic nephropathy but not HbA1c is predictive for frequent complications of Charcot feet - long-term follow-up of 164 consecutive patients with 195 acute Charcot feet. , 2012, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[18]  G. Botek,et al.  Charcot neuroarthropathy: An often overlooked complication of diabetes , 2010, Cleveland Clinic Journal of Medicine.

[19]  C. Ramanujam,et al.  An overview of conservative treatment options for diabetic Charcot foot neuroarthropathy , 2011, Diabetic foot & ankle.

[20]  G. Reddy Glucose‐mediated in vitro glycation modulates biomechanical integrity of the soft tissues but not hard tissues , 2003, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[21]  C. Saltzman,et al.  How Effective Is Intensive Nonoperative Initial Treatment of Patients with Diabetes and Charcot Arthropathy of the Feet? , 2005, Clinical orthopaedics and related research.

[22]  W. F. Todd,et al.  The natural history of acute Charcot's arthropathy in a diabetic foot specialty clinic. , 1997, Diabetic medicine : a journal of the British Diabetic Association.

[23]  M. Hernández-Herrero,et al.  Triggering mechanisms of neuroarthropathy following conservative surgery for osteomyelitis , 2010, Diabetic medicine : a journal of the British Diabetic Association.

[24]  M. Edmonds,et al.  The medial column Synthes Midfoot Fusion Bolt is associated with unacceptable rates of failure in corrective fusion for Charcot deformity: Results from a consecutive case series. , 2015, The bone & joint journal.

[25]  R. Frykberg,et al.  Epidemiology of the Charcot foot. , 2008, Clinics in podiatric medicine and surgery.

[26]  G. Rümenapf,et al.  Diabetische neuropathische Osteoarthropathie (Charcot-Fuß) , 2003 .

[27]  M. Wünschel,et al.  Charcot arthropathy of the first metatarsophalangeal joint. , 2012, Journal of the American Podiatric Medical Association.

[28]  N. Papanas,et al.  Charcot osteoarthropathy in diabetes: A brief review with an emphasis on clinical practice. , 2011, World journal of diabetes.

[29]  R. Gupta,et al.  A short history of neuropathic arthropathy. , 1993, Clinical orthopaedics and related research.

[30]  A. Jirkovska,et al.  Intranasal Calcitonin in the Treatment of Acute Charcot Neuroosteoarthropathy , 2006, Diabetes Care.

[31]  W. Morrison,et al.  Work-up of the diabetic foot. , 2002, Radiologic clinics of North America.

[32]  F. Ergen,et al.  Current challenges in imaging of the diabetic foot , 2012, Diabetic foot & ankle.

[33]  Aziz Nather,et al.  Assessment of sensory neuropathy in patients with diabetic foot problems , 2011, Diabetic foot & ankle.

[34]  M. Zou,et al.  A Comparison of Tissue versus Swab Culturing of Infected Diabetic Foot Wounds , 2016, International journal of endocrinology.

[35]  J. Charcot Sur quelques arthropathies qui paraissent dépendre d'une lésion du cerveau ou de la moelle épinière , 1868 .

[36]  E. Chantelau,et al.  Is the Eichenholtz classification still valid for the diabetic Charcot foot? , 2014, Swiss medical weekly.

[37]  V. J. Sammarco Superconstructs in the treatment of charcot foot deformity: plantar plating, locked plating, and axial screw fixation. , 2009, Foot and ankle clinics.

[38]  Bijan Najafi,et al.  Diabetic Foot Biomechanics and Gait Dysfunction , 2010, Journal of diabetes science and technology.

[39]  Benjamin A Lipsky,et al.  IWGDF guidance on the diagnosis and management of foot infections in persons with diabetes , 2016, Diabetes/metabolism research and reviews.

[40]  Y. Aurell,et al.  Role of Wnt/β-catenin and RANKL/OPG in bone healing of diabetic Charcot arthropathy patients , 2015, Acta orthopaedica.