Useful method to monitor the physiological effects of alcohol ingestion by combination of micro-integrated laser Doppler blood flow meter and arm-raising test

Alcohol has a variety of effects on the human body, affecting both the sympathetic and parasympathetic nervous system. We examined the peripheral blood flow of alcohol drinkers using a micro-integrated laser Doppler blood flow meter (micro-electromechanical system blood flow sensor). An increased heart rate and blood flow was recorded at the earlobe after alcohol ingestion, and we observed strong correlation between blood flow, heart rate, and breath alcohol content in light drinkers; but not heavy drinkers. We also found that the amplitude of pulse waves measured at the fingertip during an arm-raising test significantly decreased on alcohol consumption, regardless of the individual’s alcohol tolerance. Our micro-electromechanical system blood flow sensor successfully detected various physiological changes in peripheral blood circulation induced by alcohol consumption.

[1]  R. D. Hawkins,et al.  The metabolism of ethanol and its metabolic effects. , 1972, Pharmacological reviews.

[2]  T Kano,et al.  Fundamental patterns and characteristics of the laser-Doppler skin blood flow waves recorded from the finger or toe. , 1993, Journal of the autonomic nervous system.

[3]  J. Hayano,et al.  Effects of sympathetic nerve blockades on low-frequency oscillations of human earlobe skin blood flow. , 1999, Journal of the autonomic nervous system.

[4]  Renshi Sawada,et al.  Integrated Laser Doppler Blood Flowmeter Designed to Enable Wafer-Level Packaging , 2010, IEEE Transactions on Biomedical Engineering.

[5]  M. Kupari Acute cardiovascular effects of ethanol A controlled non-invasive study. , 1983, British heart journal.

[6]  Hirofumi Nogami,et al.  Use of a simple arm-raising test with a portable laser Doppler blood flow meter to detect dehydration , 2011 .

[7]  P Rolfe,et al.  Laser Doppler velocimetry: the problem of fibre movement artefact. , 1987, Journal of biomedical engineering.

[8]  S. Higuchi,et al.  Ethanol patch test--a simple and sensitive method for identifying ALDH phenotype. , 1989, Alcoholism, clinical and experimental research.

[9]  D. Goldman Aldehyde Dehydrogenase Deficiency as Cause of Facial Flushing Reaction to Alcohol in Japanese , 1995, Alcohol health and research world.

[10]  C. Lieber,et al.  Hepatic microsomal ethanol oxidizing system (MEOS): differentiation from alcohol dehydrogenase and NADPH oxidase. , 1970, Biochemical and biophysical research communications.

[11]  Renshi Sawada,et al.  An integrated laser blood flowmeter , 2003 .

[12]  E. Sellers,et al.  Effect of alcohol on cardiovascular reflexes. , 1977, Journal of studies on alcohol.

[13]  D. Agarwal,et al.  Population genetic and family studies on aldehyde dehydrogenase deficiency and alcohol sensitivity. , 1985, Alcohol.

[14]  R. Nossal,et al.  Model for laser Doppler measurements of blood flow in tissue. , 1981, Applied optics.

[15]  D. Agarwal,et al.  Electrophoretic and biochemical studies of human aldehyde dehydrogenase isozymes in various tissues. , 1980, Life sciences.

[16]  Patrick F. Rock,et al.  Sensitivity , 2014, Radiopaedia.org.

[17]  城戸 真希子 Assessment of abnormal blood flow and efficacy of treatment in patients with systemic sclerosis using a newly developed microwireless laser Doppler flowmeter and arm-raising test , 2008 .