Microfluidics analysis of nanoparticle mixing in a microchannel system

The microfluidics of controlled nanodrug delivery to living cells in a representative, partially heated microchannel was analyzed, using a validated computer model. The objective was to achieve uniform nanoparticle exit concentrations at a minimum microchannel length with the aid of simple static mixers, e.g., a multi-baffle-slit or perforated injection micro-mixer. A variable wall heat flux, which influences the local nanofluid properties and carrier-fluid velocities, was added to ensure that mixture delivery to the living cells occurred at the required (body) temperature of 37°C. The results show that both the baffle-slit micro-mixer and the perforated injection micro-mixer aid in decreasing the microchannel length while achieving uniform nanoparticle exit concentrations. The injection micro-mixer not only decreases best the system’s dimension, but also reduces the system power requirement. The baffle-slit micro-mixer also decreases the microchannel length; however, it may add to the power requirement. The imposed wall heat flux aids in enhanced nanoparticle and base-fluid mixing as well.

[1]  Clement Kleinstreuer,et al.  Microfluidics of nano-drug delivery , 2008 .

[2]  E. B. Nauman,et al.  Static Mixers in the Process Industries—A Review , 2003 .

[3]  W. Roetzel,et al.  Conceptions for heat transfer correlation of nanofluids , 2000 .

[4]  Nam-Trung Nguyen,et al.  Micromixers: Fundamentals, Design, and Fabrication , 2008 .

[5]  Amy Cha-Tien Sun,et al.  Computational modeling and comparison of three co-laminar microfluidic mixing techniques , 2008 .

[6]  Paul Yager,et al.  Simple quantitative optical method for monitoring the extent of mixing applied to a novel microfluidic mixer , 2004 .

[7]  V. Hessel,et al.  Passive micromixers for applications in the microreactor and μTAS fields , 2005 .

[8]  Clement Kleinstreuer,et al.  Biofluid Dynamics: Principles and Selected Applications , 2006 .

[9]  Jie Li,et al.  Computational Analysis of Nanofluid Flow in Microchannels with Applications to Micro-heat Sinks and Bio-MEMS , 2008 .

[10]  D. Leslie-Pelecky,et al.  Biomedical Applications of Nanotechnology , 2007 .

[11]  J. P. Golden,et al.  Characterization of passive microfluidic mixers fabricated using soft lithography , 2006 .

[12]  Ruey-Jen Yang,et al.  Electrokinetic mixing in microfluidic systems , 2007 .

[13]  Steven S. Saliterman,et al.  Fundamentals of bioMEMS and medical microdevices , 2006 .

[14]  J. Maxwell.  A Treatise on Electricity and Magnetism , 1873, Nature.

[15]  I. Mezić,et al.  Chaotic Mixer for Microchannels , 2002, Science.

[16]  J. Koo,et al.  Liquid flow in microchannels: experimental observations and computational analyses of microfluidics effects , 2003 .

[17]  Dong Sung Kim,et al.  A barrier embedded chaotic micromixer , 2004 .

[18]  Nam-Trung Nguyen,et al.  Micromixers?a review , 2005 .

[19]  Patrick Patrick Anderson,et al.  Chaotic mixing using periodic and aperiodic sequences of mixing protocols in a micromixer , 2008 .

[20]  T. R. Shih,et al.  Effect of geometry on fluid mixing of the rhombic micromixers , 2008 .

[21]  C. Kleinstreuer,et al.  Discussion: “Effects of Various Parameters on Nanofluid Thermal Conductivity” (Jang, S. P., and Choi, S. D. S., 2007, ASME J. Heat Transfer, 129, pp. 617–623) , 2008 .