Early administration of hyperbaric oxygen therapy in distraction osteogenesis--a quantitative study in New Zealand rabbits.

BACKGROUND We investigated the effect of hyperbaric oxygen (HBO) therapy on the early phase of tibial lengthening in our established rabbit model. METHODS Twenty-four male rabbits (six per group) underwent right tibial lengthening by 5 mm. Group 1 then underwent 2.5 atmospheres of absolute hyperbaric oxygenation for 2 hours daily for 6 weeks postoperatively; group 2, for early 5 weeks (weeks 1-5), group 3, for late 5 weeks (weeks 2-6), and group 4 had no HBO therapy. Bone mineral density (BMD) was measured before surgery and weekly thereafter from weeks 2 through 6. The mechanical strengths of the lengthened tibias were measured. RESULTS Significantly higher mean %BMDs were obtained for groups 1 and 2 compared with groups 3 and 4. There was no difference in the mean %BMD between groups 1 and 2 (p > 0.05). The results were similar for mean percentage maximal torque; group 1 had the maximum torque, followed sequentially by groups 2 though 4. CONCLUSION The study results suggest that early and full-term administration of HBO therapy on tibial lengthening may achieve better benefits.

[1]  S. Ueng,et al.  Bone healing of tibial lengthening is enhanced by hyperbaric oxygen therapy: a study of bone mineral density and torsional strength on rabbits. , 1998, The Journal of trauma.

[2]  Ming-Yih Lee,et al.  Effect of intermittent cigarette smoke inhalation on tibial lengthening: experimental study on rabbits. , 1997, The Journal of trauma.

[3]  S. Ch,et al.  Ilizarov femoral lengthening in adults. , 1995 .

[4]  C. Hamanishi,et al.  Bone mineral density of lengthened rabbit tibia is enhanced by transplantation of fresh autologous bone marrow cells. An experimental study using dual X-ray absorptiometry. , 1994, Clinical orthopaedics and related research.

[5]  C. Hammarlund,et al.  Hyperbaric oxygen reduced size of chronic leg ulcers: a randomized double-blind study. , 1994, Plastic and reconstructive surgery.

[6]  L. Gottlieb,et al.  Hyperbaric oxygen therapy in plastic surgery: a review article. , 1991, Plastic and reconstructive surgery.

[7]  J. Kenwright,et al.  The timing of distraction of an osteotomy. , 1990, The Journal of bone and joint surgery. British volume.

[8]  G A Ilizarov,et al.  The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. , 1989, Clinical orthopaedics and related research.

[9]  T. Goto,et al.  Bone lengthening in rabbits by callus distraction. The role of periosteum and endosteum. , 1988, The Journal of bone and joint surgery. British volume.

[10]  L. Rogers,et al.  Effect of hyperbaric oxygenation upon fracture healing in the rat. , 1968, The Journal of surgical research.

[11]  R. Cruess,et al.  The effect of hyperbaric oxygen on fracture healing in rats. , 1968, The Journal of trauma.

[12]  J. Kanis,et al.  New bone formation during leg lengthening. Evaluated by dual energy X-ray absorptiometry. , 1993, The Journal of bone and joint surgery. British volume.

[13]  G A Ilizarov,et al.  The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. , 1989, Clinical orthopaedics and related research.