Discovery and Development of Telaprevir
暂无分享,去创建一个
B. Govinda Rao | Ann D. Kwong | A. Kwong | B. G. Rao | I. Weisberg | I. Jacobson | R. Perni | Ira M. Jacobson | Anne-Laure Grillot | Luc J. Farmer | William P. Taylor | Ilan Weisberg | Robert B. Perni | W. Taylor | A. Grillot | L. Farmer | B. Rao | William P. Taylor
[1] R. Purcell,et al. The hepatitis C virus: Overview , 1997, Hepatology.
[2] Tara L. Kieffer,et al. Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir. , 2007, Gastroenterology.
[3] Dieter Häussinger,et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. , 2002, The New England journal of medicine.
[4] Jean-Michel Pawlotsky,et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. , 2009, The New England journal of medicine.
[5] S. Harbeson,et al. Stereospecific synthesis of peptidyl alpha-keto amides as inhibitors of calpain. , 1994, Journal of medicinal chemistry.
[6] T. Asselah,et al. Protease and polymerase inhibitors for the treatment of hepatitis C , 2009, Liver international : official journal of the International Association for the Study of the Liver.
[7] S. Raybuck,et al. Mechanistic role of an NS4A peptide cofactor with the truncated NS3 protease of hepatitis C virus: elucidation of the NS4A stimulatory effect via kinetic analysis and inhibitor mapping. , 1997, Biochemistry.
[8] H. Parge,et al. The Crystal Structure of Hepatitis C Virus NS3 Proteinase Reveals a Trypsin-like Fold and a Structural Zinc Binding Site , 1996, Cell.
[9] M. Murcko,et al. Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide , 1996, Cell.
[10] G. Everson,et al. Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. , 2009, The New England journal of medicine.
[11] B. G. Rao,et al. Inhibitors of hepatitis C virus NS3.4A protease 1. Non-charged tetrapeptide variants. , 2003, Bioorganic & medicinal chemistry letters.
[12] N. Cammack,et al. Inhibition of native hepatitis C virus replicase by nucleotide and non-nucleoside inhibitors. , 2005, Virology.
[13] John R Fulghum,et al. In Vitro Resistance Studies of Hepatitis C Virus Serine Protease Inhibitors, VX-950 and BILN 2061 , 2004, Journal of Biological Chemistry.
[14] J. Timm,et al. Serine protease inhibitors as anti-hepatitis C virus agents , 2009, Expert review of anti-infective therapy.
[15] Tara L. Kieffer,et al. Antiviral activity of telaprevir (VX‐950) and peginterferon alfa‐2a in patients with hepatitis C , 2007, Hepatology.
[16] B. G. Rao,et al. Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization. , 2004, Bioorganic & medicinal chemistry letters.
[17] Tara L. Kieffer,et al. Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjects. , 2008, The Journal of infectious diseases.
[18] Ann D. Kwong,et al. VX-950, a Novel Hepatitis C Virus (HCV) NS3-4A Protease Inhibitor, Exhibits Potent Antiviral Activities in HCV Replicon Cells , 2006, Antimicrobial Agents and Chemotherapy.
[19] Alan S. Perelson,et al. Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy , 1998 .
[20] L. Seeff,et al. Aasld Practice Guideline Diagnosis, Management, and Treatment of Hepatitis C , 2003 .
[21] M. Onji,et al. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[22] T. Hassanein,et al. Hepatitis C virus: a critical appraisal of approaches to therapy. , 2009, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
[23] F. Penin,et al. Membrane Association of the RNA-Dependent RNA Polymerase Is Essential for Hepatitis C Virus RNA Replication , 2004, Journal of Virology.
[24] Tara L. Kieffer,et al. Telaprevir and pegylated interferon–alpha‐2a inhibit wild‐type and resistant genotype 1 hepatitis C virus replication in patients , 2007, Hepatology.
[25] William M. Lee,et al. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. , 2009, The New England journal of medicine.
[26] Kenneth Koury,et al. For Personal Use. Only Reproduce with Permission from the Lancet Publishing Group , 2022 .
[27] I. Ugi,et al. Multicomponent Reactions with Isocyanides. , 2000, Angewandte Chemie.
[28] F. López-Labrador. Hepatitis C Virus NS3/4A Protease Inhibitors. , 2008, Recent Patents on Anti-Infective Drug Discovery.
[29] P. Jansen,et al. New developments in the antiviral treatment of hepatitis C , 2009, Vox sanguinis.
[30] I. Jacobson,et al. New and experimental therapies for HCV , 2009, Nature Reviews Gastroenterology &Hepatology.
[31] I. Weisberg,et al. Telaprevir: hope on the horizon, getting closer. , 2009, Clinics in liver disease.
[32] R. Copeland,et al. Drug–target residence time and its implications for lead optimization , 2007, Nature Reviews Drug Discovery.
[33] J. Glass,et al. Discovery of a novel bicycloproline P2 bearing peptidyl alpha-ketoamide LY514962 as HCV protease inhibitor. , 2004, Bioorganic & medicinal chemistry letters.
[34] C. Rice,et al. A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro , 1995, Journal of virology.
[35] T. Berg,et al. Expert opinion on the treatment of patients with chronic hepatitis C , 2009, Journal of viral hepatitis.
[36] B. Kronenberger,et al. Current and future treatment options for HCV. , 2009, Annals of hepatology.
[37] A. Kwong,et al. Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease , 2006, Antimicrobial Agents and Chemotherapy.
[38] J. Macías,et al. A review of current anti-HCV treatment regimens and possible future strategies , 2009, Expert opinion on pharmacotherapy.
[39] H J Alter,et al. Recovery, Persistence, and Sequelae in Hepatitis C Virus Infection: A Perspective on Long-Term Outcome , 2000, Seminars in liver disease.
[40] A. Kwong,et al. In Vitro Studies of Cross-resistance Mutations against Two Hepatitis C Virus Serine Protease Inhibitors, VX-950 and BILN 2061* , 2005, Journal of Biological Chemistry.
[41] R. Francesco,et al. An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A , 1995, Journal of virology.
[42] Charles M. Rice,et al. Unravelling hepatitis C virus replication from genome to function , 2005, Nature.
[43] M. Murcko,et al. Inhibitors of hepatitis C virus NS3.4A protease. Part 3: P2 proline variants. , 2004, Bioorganic & medicinal chemistry letters.
[44] K. Shimotohno,et al. Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing , 1995, Journal of virology.
[45] V. Soriano,et al. New therapies for hepatitis C virus infection. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[46] C. Rice,et al. The hepatitis C virus NS3 serine proteinase and NS4A cofactor: establishment of a cell-free trans-processing assay. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[47] J. Silver,et al. Replication of Subgenomic Hepatitis C Virus Rnas in a Hepatoma Cell Line , 1999 .
[48] R. Francesco,et al. Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins , 1994, Journal of virology.
[49] J. McHutchison,et al. Antiviral effects and safety of telaprevir, peginterferon alfa-2a, and ribavirin for 28 days in hepatitis C patients. , 2008, Journal of hepatology.
[50] R. Bartenschlager,et al. Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation , 1995, Journal of virology.
[51] A. Urbani,et al. A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates. , 1996, Analytical biochemistry.
[52] S. Zeuzem,et al. Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase Ib, placebo-controlled, randomized study. , 2006, Gastroenterology.
[53] G. Castaldo,et al. Telaprevir: a promising protease inhibitor for the treatment of hepatitis C virus infection. , 2009, Current medicinal chemistry.
[54] J. Monn,et al. A Concise, Stereocontrolled Thiazolium Ylide Approach to Kainic Acid , 1994 .
[55] A. Kwong,et al. Recent progress in the development of selected hepatitis C virus NS3.4A protease and NS5B polymerase inhibitors. , 2008, Current opinion in pharmacology.
[56] A. Kwong,et al. Serine protease of hepatitis C virus expressed in insect cells as the NS3/4A complex. , 1998, Biochemistry.
[57] A. Kwong,et al. Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease. , 2006, Infectious disorders drug targets.
[58] Todd M. Allen,et al. Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment‐naïve patients , 2008, Hepatology.
[59] A. Salonen,et al. Viral RNA Replication in Association with Cellular Membranes , 2005, Current topics in microbiology and immunology.
[60] D. Fairlie,et al. Protease inhibitors: current status and future prospects. , 2000, Journal of medicinal chemistry.
[61] S. Kanemasa,et al. Highly diastereoselective Michael addition of lithiated camphor imines of glycine esters to α,β-unsaturated esters. Synthesis of optically pure 5-oxo-2,4-pyrrolidinedicarboxylates of unnatural stereochemistry , 1991 .