Immune networks: getting on to the real thing.

After some ten years of faltering development, the network approach in immunology is finally heading toward steady ground. At a recent international workshop (*), experimentalists and theoreticians discussed some of the latest developments, including an impressive array of novel results and applications to fundamental properties of biological immune networks: connectivity, patterns of dynamic activity, ontogenesis, and tolerance.

[1]  Pauline Hogeweg,et al.  Memory but no suppression in low-dimensional symmetric idiotypic networks , 1989, Bulletin of mathematical biology.

[2]  A. Coutinho,et al.  Reactions among IgM antibodies derived from normal, neonatal mice , 1984, European journal of immunology.

[3]  Sompolinsky,et al.  Dynamics of spin systems with randomly asymmetric bonds: Langevin dynamics and a spherical model. , 1987, Physical review. A, General physics.

[4]  M. Mézard,et al.  Spin Glass Theory and Beyond , 1987 .

[5]  A. Coutinho,et al.  Tolerize one, tolerize them all: tolerance is self-assertion. , 1989, Immunology today.

[6]  G. Oster,et al.  Theoretical studies of clonal selection: minimal antibody repertoire size and reliability of self-non-self discrimination. , 1979, Journal of theoretical biology.

[7]  J. Urbain Is the immune system a functional idiotypic network?: Idiotypic networks: A noisy background or a breakthough in immunological thinking? , 1986 .

[8]  Internal connectivity is pervasive among primary and secondary anti-hen egg white lysozyme (HEL) IgG monoclonal antibodies. , 1989, International immunology.

[9]  A. Perelson Immune Network Theory , 1989, Immunological reviews.

[10]  J. Urbain,et al.  Immunoregulatory role of maternal idiotypes. Ontogeny of immune networks , 1980, The Journal of experimental medicine.

[11]  R. J. Boer Poor repertoire selection in symmetric idiotypic network models , 1989 .

[12]  A. Coutinho,et al.  Beyond Clonal Selection and Network , 1989, Immunological reviews.

[13]  F. Varela,et al.  Exploring the Meaning of Connectivity in the Immune Network , 1989, Immunological reviews.