Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes

The serum lipidomic profile associated with neuropathy in type 2 diabetes is not well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting lipid profiles early during type 2 diabetes may identify individuals who develop neuropathy later in the disease course. This retrospective cohort study examined lipidomic profiles 10 years prior to type 2 diabetic neuropathy assessment.

[1]  J. Hur,et al.  Plasma Metabolomics and Lipidomics Differentiate Obese Individuals by Peripheral Neuropathy Status. , 2021, The Journal of clinical endocrinology and metabolism.

[2]  G. Michailidis,et al.  Diminished retinal complex lipid synthesis and impaired fatty acid β-oxidation associated with human diabetic retinopathy , 2021, JCI insight.

[3]  P. Bennett,et al.  Pima Indian Contributions to Our Understanding of Diabetic Kidney Disease , 2021, Diabetes.

[4]  M. Banerjee,et al.  The determinants of complication trajectories in American Indians with type 2 diabetes , 2021, JCI insight.

[5]  M. Jørgensen,et al.  Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes , 2021, Annals of clinical and translational neurology.

[6]  Kenneth J. Smith,et al.  High Dietary Fat Consumption Impairs Axonal Mitochondrial Function In Vivo , 2021, The Journal of Neuroscience.

[7]  V. Dubey,et al.  Predicting Diabetic Neuropathy Risk Level Using Artificial Neural Network and Clinical Parameters of Subjects With Diabetes , 2020, Journal of diabetes science and technology.

[8]  M. Roden,et al.  Association of cardiac autonomic dysfunction with higher levels of plasma lipid metabolites in recent-onset type 2 diabetes , 2020, Diabetologia.

[9]  Xue Cai,et al.  Prevalence and Risk Factors for Diabetic Peripheral Neuropathy in Type 2 Diabetic Patients From 14 Countries: Estimates of the INTERPRET-DD Study , 2020, Frontiers in Public Health.

[10]  H. Sørensen,et al.  Statin Therapy and Risk of Polyneuropathy in Type 2 Diabetes: A Danish Cohort Study , 2020, Diabetes Care.

[11]  J. Hui,et al.  High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies , 2020, PLoS biology.

[12]  M. Banerjee,et al.  Central Obesity is Associated With Neuropathy in the Severely Obese. , 2020, Mayo Clinic proceedings.

[13]  H. Sørensen,et al.  Metabolic Factors, Lifestyle Habits, and Possible Polyneuropathy in Early Type 2 Diabetes: A Nationwide Study of 5,249 Patients in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Cohort , 2020, Diabetes Care.

[14]  E. Feldman,et al.  The emerging role of dyslipidemia in diabetic microvascular complications. , 2020, Current opinion in endocrinology, diabetes, and obesity.

[15]  Xiang Chen,et al.  The mechanisms of lysophosphatidylcholine in the development of diseases. , 2020, Life sciences.

[16]  M. Banerjee,et al.  The Prevalence and Determinants of Cognitive Deficits and Traditional Diabetic Complications in the Severely Obese , 2020, Diabetes Care.

[17]  M. Banerjee,et al.  The metabolic drivers of neuropathy in India. , 2018, Journal of diabetes and its complications.

[18]  C. Gelfi,et al.  Sphingolipids in Obesity and Correlated Co-Morbidities: The Contribution of Gender, Age and Environment , 2019, International journal of molecular sciences.

[19]  G. Michailidis,et al.  Increased lipogenesis and impaired β-oxidation predict type 2 diabetic kidney disease progression in American Indians. , 2019, JCI insight.

[20]  E. Feldman,et al.  Diabetic neuropathy , 2019, Nature Reviews Disease Primers.

[21]  E. Feldman,et al.  The Divergent Roles of Dietary Saturated and Monounsaturated Fatty Acids on Nerve Function in Murine Models of Obesity , 2019, The Journal of Neuroscience.

[22]  S. Eid,et al.  Integrated lipidomic and transcriptomic analyses identify altered nerve triglycerides in mouse models of prediabetes and type 2 diabetes , 2019, Disease Models & Mechanisms.

[23]  E. Feldman,et al.  Disorders of mitochondrial dynamics in peripheral neuropathy: Clues from hereditary neuropathy and diabetes. , 2019, International review of neurobiology.

[24]  E. Feldman,et al.  Chain length of saturated fatty acids regulates mitochondrial trafficking and function in sensory neurons , 2018, Journal of Lipid Research.

[25]  Vishal M. Gohil,et al.  The role of nonbilayer phospholipids in mitochondrial structure and function , 2018, FEBS letters.

[26]  G. Michailidis,et al.  Lipidomics and Biomarker Discovery in Kidney Disease. , 2018, Seminars in nephrology.

[27]  M. Banerjee,et al.  Better diagnostic accuracy of neuropathy in obesity: A new challenge for neurologists , 2018, Clinical Neurophysiology.

[28]  T. Lauritzen,et al.  Risk Factors for Incident Diabetic Polyneuropathy in a Cohort With Screen-Detected Type 2 Diabetes Followed for 13 Years: ADDITION-Denmark , 2018, Diabetes Care.

[29]  M. Banerjee,et al.  Diabetes and obesity are the main metabolic drivers of peripheral neuropathy , 2018, Annals of clinical and translational neurology.

[30]  Subramaniam Pennathur,et al.  Impaired β-Oxidation and Altered Complex Lipid Fatty Acid Partitioning with Advancing CKD. , 2017, Journal of the American Society of Nephrology : JASN.

[31]  H. V. Jagadish,et al.  Shared and distinct lipid-lipid interactions in plasma and affected tissues in a diabetic mouse model[S] , 2017, Journal of Lipid Research.

[32]  D. Vance,et al.  The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease. , 2017, Biochimica et biophysica acta. Biomembranes.

[33]  S. Saydah,et al.  Prevalence of and Risk Factors for Diabetic Peripheral Neuropathy in Youth With Type 1 and Type 2 Diabetes: SEARCH for Diabetes in Youth Study , 2017, Diabetes Care.

[34]  G. Sheridan,et al.  Lysophosphatidic acid receptors (LPARs): Potential targets for the treatment of neuropathic pain , 2017, Neuropharmacology.

[35]  M. Banerjee,et al.  Association Between Metabolic Syndrome Components and Polyneuropathy in an Obese Population. , 2016, JAMA neurology.

[36]  Kumar Sharma,et al.  Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications. , 2016, JCI insight.

[37]  Jiang He,et al.  Lipidomic Signature of Progression of Chronic Kidney Disease in the Chronic Renal Insufficiency Cohort , 2016, Kidney international reports.

[38]  M. Banerjee,et al.  Metabolic Syndrome Components Are Associated With Symptomatic Polyneuropathy Independent of Glycemic Status , 2016, Diabetes Care.

[39]  R. Nelson,et al.  Burden of Diabetic Peripheral Neuropathy in Pima Indians With Type 2 Diabetes , 2016, Diabetes Care.

[40]  M. Jensen,et al.  The Sexual Dimorphism of Lipid Kinetics in Humans , 2015, Front. Endocrinol..

[41]  Karen van Eunen,et al.  Biochemical Competition Makes Fatty-Acid β-Oxidation Vulnerable to Substrate Overload , 2013, PLoS Comput. Biol..

[42]  R. Hanson,et al.  Effect of Losartan on Prevention and Progression of Early Diabetic Nephropathy in American Indians With Type 2 Diabetes , 2013, Diabetes.

[43]  P. Wiffen.  ENHANCED GLUCOSE CONTROL FOR PREVENTING AND TREATING DIABETIC NEUROPATHY , 2012 .

[44]  J. Albers,et al.  Use of the Michigan Neuropathy Screening Instrument as a measure of distal symmetrical peripheral neuropathy in Type 1 diabetes: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications , 2012, Diabetic medicine : a journal of the British Diabetic Association.

[45]  S. Carr,et al.  Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. , 2011, The Journal of clinical investigation.

[46]  Jennifer Y. Liu,et al.  Triglycerides and Amputation Risk in Patients With Diabetes , 2011, Diabetes Care.

[47]  Jennifer Y. Liu,et al.  Triglycerides and Amputation Risk in PatientsWith Diabetes Ten-year follow-up in the DISTANCE study , 2011 .

[48]  Xiao Han,et al.  A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice. , 2009, American journal of physiology. Endocrinology and metabolism.

[49]  M B Brown,et al.  A Practical Two-Step Quantitative Clinical and Electrophysiological Assessment for the Diagnosis and Staging of Diabetic Neuropathy , 1994, Diabetes Care.

[50]  P. Bennett,et al.  Diabetes mellitus in American (Pima) Indians. , 1971, Lancet.