A solution for reliable and valid reduction of ocular artifacts, applied to the P300 ERP.

The P300 ERP was measured in 10 subjects each for 9 days. The selection of instructions for subjects, the recording technique, the elimination of a few single trials significantly contaminated by eye movements, and the use of a correction procedure for ocular artifacts with calculable reliability and validity resulted in a set of data, in which 94% of the single trials were suitable for further analysis. The correction procedure relies on regression analysis. To reduce coherence between eyeblink activity and ongoing EEG, VEOG and EEG are averaged on eyeblinks. This yields a high reliability and validity of regression factors, determined per day, subject, and lead. In addition, this correction procedure allows for an estimation of the maximal error that must be taken into account. The efficiency of the procedure is demonstrated for single trials and averaged potentials.

[1]  W G Walter,et al.  The effects of attention and distraction on the contingent negative variation in normal and neurotic subjects. , 1968, Electroencephalography and clinical neurophysiology.

[2]  D. Overton,et al.  Distribution of eye movement and eyeblink potentials over the scalp. , 1969, Electroencephalography and clinical neurophysiology.

[3]  S. Hillyard,et al.  Eye movement artifact in the CNV. , 1970, Electroencephalography and clinical neurophysiology.

[4]  J. C. Corby,et al.  Differential contributions of blinks and vertical eye movements as artifacts in EEG recording. , 1972, Psychophysiology.

[5]  S. Hillyard,et al.  Electrical Signs of Selective Attention in the Human Brain , 1973, Science.

[6]  A. Winter,et al.  New techniques for the control of eye potential artefacts in multichannel CNV recordings. , 1973, Electroencephalography and clinical neurophysiology.

[7]  J. Kamiya,et al.  A simple on-line technique for removing eye movement artifacts from the EEG. , 1973, Electroencephalography and clinical neurophysiology.

[8]  P. Lang,et al.  The effects of eye fixation and stimulus and response location on the contingent negative variation (CNV). , 1973, Biological psychology.

[9]  N. Squires,et al.  Two varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man. , 1975, Electroencephalography and clinical neurophysiology.

[10]  H. Moldofsky,et al.  A spectral method for removing eye movement artifacts from the EEG. , 1978, Electroencephalography and clinical neurophysiology.

[11]  A Pfefferbaum,et al.  Event-related potentials in schizophrenics. , 1980, Electroencephalography and clinical neurophysiology.

[12]  H. Bauer,et al.  Concept identification as a function of preceding negative or positive spontaneous shifts in slow brain potentials. , 1981, Psychophysiology.

[13]  T. Gasser,et al.  Correction of EOG artifacts in event-related potentials of the EEG: aspects of reliability and validity. , 1982, Psychophysiology.

[14]  J. C. Woestenburg,et al.  The removal of the eye-movement artifact from the EEG by regression analysis in the frequency domain , 1983, Biological Psychology.

[15]  C. Fortgens,et al.  Removal of eye movement and ECG artifacts from the non-cephalic reference EEG. , 1983, Electroencephalography and clinical neurophysiology.

[16]  E Donchin,et al.  A new method for off-line removal of ocular artifact. , 1983, Electroencephalography and clinical neurophysiology.

[17]  T. Gasser,et al.  The transfer of EOG activity into the EEG for eyes open and closed. , 1985, Electroencephalography and clinical neurophysiology.

[18]  R. Hari,et al.  Magnetic fields produced by eye blinking. , 1985, Electroencephalography and clinical neurophysiology.

[19]  B. Rockstroh,et al.  Removal of ocular artifacts from the EEG--a biophysical approach to the EOG. , 1985, Electroencephalography and clinical neurophysiology.