THE EFFECT OF INDUCED HYPOTHERMIA UPON OXYGEN CONSUMPTION IN THE RAT BRAIN

The effect of hypothermia upon cerebral metabolic rate for oxygen (CMRO2) was studied in artificially ventilated rats, anaesthetized with nitrous oxide. Cerebral blood flow was measured with a modification of the Kety and Schmidt technique using 133xenon. CMRO2, was found to decrease linearily with temperature in the temperature range 37°C‐22°C. At normal temperatures CMRO2, fell by about 5 per cent per degree C. At a body temperature of 22°C both cerebral blood flow and CMRO2, were reduced to about 25 per cent of normal.

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