DAF-16 target identification in C. elegans: past, present and future

[1]  B. Kuster,et al.  Mass-spectrometry-based draft of the human proteome , 2014, Nature.

[2]  B. Kennedy,et al.  Drugs that modulate aging: the promising yet difficult path ahead. , 2014, Translational research : the journal of laboratory and clinical medicine.

[3]  A. Samuelson,et al.  The Caenorhabditis elegans Myc-Mondo/Mad Complexes Integrate Diverse Longevity Signals , 2014, PLoS genetics.

[4]  Jennifer M. A. Tullet,et al.  Cell-Nonautonomous Effects of dFOXO/DAF-16 in Aging , 2014, Cell reports.

[5]  Irene Papatheodorou,et al.  MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans , 2014, Aging.

[6]  Jennifer M. A. Tullet,et al.  DAF-16/FoxO Directly Regulates an Atypical AMP-Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in Caenorhabditis elegans , 2014, PLoS genetics.

[7]  Yee Lian Chew,et al.  Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome , 2014, Cellular and Molecular Life Sciences.

[8]  A. Hubbard,et al.  Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. , 2013, Cell reports.

[9]  Christian Frøkjær-Jensen.  Exciting Prospects for Precise Engineering of Caenorhabditis elegans Genomes with CRISPR/Cas9 , 2013, Genetics.

[10]  David G. Camp,et al.  Reduced Insulin/Insulin-like Growth Factor-1 Signaling and Dietary Restriction Inhibit Translation but Preserve Muscle Mass in Caenorhabditis elegans * , 2013, Molecular & Cellular Proteomics.

[11]  Ronald G. Tepper,et al.  PQM-1 Complements DAF-16 as a Key Transcriptional Regulator of DAF-2-Mediated Development and Longevity , 2013, Cell.

[12]  H. Korswagen,et al.  Molecular Systems Biology 9; Article number 679; doi:10.1038/msb.2013.35 Citation: Molecular Systems Biology 9:679 , 2022 .

[13]  David Gems,et al.  Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction? , 2013, Antioxidants & redox signaling.

[14]  Seung-Jae V. Lee,et al.  Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. , 2013, Cell metabolism.

[15]  C. Murphy,et al.  The Intersection of Aging, Longevity Pathways, and Learning and Memory in C. elegans , 2012, Front. Gene..

[16]  T. Hashimshony,et al.  CEL-Seq: single-cell RNA-Seq by multiplexed linear amplification. , 2012, Cell reports.

[17]  E. Neumann-Haefelin,et al.  Cell-Nonautonomous Signaling of FOXO/DAF-16 to the Stem Cells of Caenorhabditis elegans , 2012, PLoS genetics.

[18]  Gyan Bhanot,et al.  Neurite Sprouting and Synapse Deterioration in the Aging Caenorhabditis elegans Nervous System , 2012, The Journal of Neuroscience.

[19]  Kira Glover-Cutter,et al.  TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. , 2012, Cell metabolism.

[20]  Bradford W Gibson,et al.  Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan , 2012, Aging cell.

[21]  Simon Melov,et al.  Loss of intestinal nuclei and intestinal integrity in aging C. elegans , 2011, Aging cell.

[22]  C. Wolkow,et al.  Regulation of Caenorhabditis elegans vitellogenesis by DAF-2/IIS through separable transcriptional and posttranscriptional mechanisms , 2011, BMC Physiology.

[23]  C. Kenyon,et al.  Spontaneous Age-Related Neurite Branching in Caenorhabditis elegans , 2011, The Journal of Neuroscience.

[24]  C. Holmberg,et al.  Specific SKN-1/Nrf Stress Responses to Perturbations in Translation Elongation and Proteasome Activity , 2011, PLoS genetics.

[25]  Mark Gerstein,et al.  Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans. , 2011, Genome research.

[26]  C. Murphy,et al.  Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms , 2011, Genesis.

[27]  M. Hansen,et al.  A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in -1 , 2011 .

[28]  L. Christiansen,et al.  Replication of an association of variation in the FOXO3A gene with human longevity using both case–control and longitudinal data , 2010, Aging cell.

[29]  A. Hubbard,et al.  Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. , 2010, Cell metabolism.

[30]  Janet M Thornton,et al.  DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO , 2010, Molecular systems biology.

[31]  Jennifer M. A. Tullet,et al.  RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition , 2010, PLoS genetics.

[32]  Avni Mehta,et al.  drr‐2 encodes an eIF4H that acts downstream of TOR in diet‐restriction‐induced longevity of C. elegans , 2010, Aging cell.

[33]  Alma L. Burlingame,et al.  Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans , 2010, PLoS biology.

[34]  Di Chen,et al.  With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. , 2010, Cell metabolism.

[35]  C. Murphy,et al.  Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age , 2010, PLoS biology.

[36]  Linda Partridge,et al.  Extending Healthy Life Span—From Yeast to Humans , 2010, Science.

[37]  C. Kenyon.  The genetics of ageing , 2010, Nature.

[38]  Yi Zeng,et al.  Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. , 2009, Human molecular genetics.

[39]  Pablo Blinder,et al.  Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice , 2009, Cell.

[40]  B. Kennedy,et al.  The TOR pathway comes of age. , 2009, Biochimica et biophysica acta.

[41]  Pui-Yan Kwok,et al.  Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity , 2009, Aging cell.

[42]  Olga G. Troyanskaya,et al.  Global Prediction of Tissue-Specific Gene Expression and Context-Dependent Gene Networks in Caenorhabditis elegans , 2009, PLoS Comput. Biol..

[43]  R. Bellazzi,et al.  Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. , 2009, Rejuvenation research.

[44]  Stefan Schreiber,et al.  Association of FOXO3A variation with human longevity confirmed in German centenarians , 2009, Proceedings of the National Academy of Sciences.

[45]  Katsuhiko Yano,et al.  FOXO3A genotype is strongly associated with human longevity , 2008, Proceedings of the National Academy of Sciences.

[46]  Lucinda K. Southworth,et al.  An elt-3/elt-5/elt-6 GATA Transcription Circuit Guides Aging in C. elegans , 2008, Cell.

[47]  Jennifer M. A. Tullet,et al.  Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans , 2008, Cell.

[48]  D. Leahy,et al.  Functionally significant insulin-like growth factor I receptor mutations in centenarians , 2008, Proceedings of the National Academy of Sciences.

[49]  J. Thaden,et al.  Remarkable longevity and stress resistance of nematode PI3K‐null mutants , 2008, Aging cell.

[50]  D. Garsin,et al.  Insulin Signaling and the Heat Shock Response Modulate Protein Homeostasis in the Caenorhabditis elegans Intestine during Infection* , 2008, Journal of Biological Chemistry.

[51]  M. Driscoll,et al.  A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans , 2008, PLoS genetics.

[52]  Cynthia Kenyon,et al.  DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans , 2007, Nature Genetics.

[53]  S. Gygi,et al.  An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegans , 2007, Current Biology.

[54]  Stephen E Von Stetina,et al.  Cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system , 2007, Genome Biology.

[55]  Seung-Jae V. Lee,et al.  Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans , 2007, Aging cell.

[56]  P. Kapahi,et al.  Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans , 2007, Aging cell.

[57]  John R Yates,et al.  Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. , 2007, Nature Reviews Molecular Cell Biology.

[58]  Janet M Thornton,et al.  Evolutionary conservation of regulated longevity assurance mechanisms , 2007, Genome Biology.

[59]  C. Murphy.  The search for DAF-16/FOXO transcriptional targets: Approaches and discoveries , 2006, Experimental Gerontology.

[60]  Ehud Cohen,et al.  Opposing Activities Protect Against Age-Onset Proteotoxicity , 2006, Science.

[61]  Valerie Reinke,et al.  p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans , 2006, PLoS genetics.

[62]  D. Garigan,et al.  Mutations That Increase the Life Span of C. elegans Inhibit Tumor Growth , 2006, Science.

[63]  R. Morimoto,et al.  Polyglutamine Proteins at the Pathogenic Threshold Display Neuron-Specific Aggregation in a Pan-Neuronal Caenorhabditis elegans Model , 2006, The Journal of Neuroscience.

[64]  Michael R. Green,et al.  Reply to Enrichment of regulatory motifs upstream of predicted DAF-16 targets , 2006, Nature Genetics.

[65]  Michael R. Green,et al.  Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation , 2006, Nature Genetics.

[66]  A. Hsu,et al.  New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen , 2005, PLoS genetics.

[67]  Donald L Riddle,et al.  Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression. , 2005, Genome research.

[68]  J. Apfeld,et al.  The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. , 2004, Genes & development.

[69]  David Gems,et al.  Shared Transcriptional Signature in Caenorhabditis elegans Dauer Larvae and Long-lived daf-2 Mutants Implicates Detoxification System in Longevity Assurance* , 2004, Journal of Biological Chemistry.

[70]  Simon Melov,et al.  Microarray analysis of gene expression with age in individual nematodes , 2004, Aging cell.

[71]  Tibor Vellai,et al.  Genetics: Influence of TOR kinase on lifespan in C. elegans , 2003, Nature.

[72]  C. Kenyon,et al.  Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan , 2003, Cell.

[73]  D. Hall,et al.  Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans , 2003, Science.

[74]  Cori Bargmann,et al.  Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans , 2003, Nature.

[75]  Cynthia Kenyon,et al.  Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor , 2003, Science.

[76]  Gary Ruvkun,et al.  DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism , 2003, Science.

[77]  J. McElwee,et al.  Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF‐16 , 2003, Aging cell.

[78]  D. Hall,et al.  Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans , 2002, Nature.

[79]  L. Partridge,et al.  Interpreting interactions between treatments that slow aging , 2002, Aging cell.

[80]  Richard I. Morimoto,et al.  The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[81]  A. Fraser,et al.  Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. , 2002, Genetics.

[82]  T. Johnson,et al.  daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans , 2001, Current Biology.

[83]  C. Kenyon,et al.  Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling , 2001, Nature Genetics.

[84]  Koutarou D. Kimura,et al.  Regulation of C. elegans life-span by insulinlike signaling in the nervous system. , 2000, Science.

[85]  S. Henikoff,et al.  Identification of in vivo DNA targets of chromatin proteins using tethered Dam methyltransferase , 2000, Nature Biotechnology.

[86]  D. Riddle,et al.  Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. , 1998, Genetics.

[87]  G. Ruvkun,et al.  The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans , 1997, Nature.

[88]  Koutarou D. Kimura,et al.  daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. , 1997, Science.

[89]  D. Riddle,et al.  Genes that regulate both development and longevity in Caenorhabditis elegans. , 1995, Genetics.

[90]  C. Kenyon,et al.  A C. elegans mutant that lives twice as long as wild type , 1993, Nature.

[91]  T. Johnson,et al.  Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. , 1988, Journal of gerontology.