Brown seaweed fucoidan: biological activity and apoptosis, growth signaling mechanism in cancer.

[1]  Jayachandran Venkatesan,et al.  Hydroxyapatite-fucoidan nanocomposites for bone tissue engineering. , 2013, International journal of biological macromolecules.

[2]  P. Hwang,et al.  Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGFβ receptor degradation in breast cancer. , 2013, Carcinogenesis.

[3]  K. Teruya,et al.  Induction of Apoptosis by Low-Molecular-Weight Fucoidan through Calcium- and Caspase-Dependent Mitochondrial Pathways in MDA-MB-231 Breast Cancer Cells , 2013, Bioscience, biotechnology, and biochemistry.

[4]  Hyunkyoung Lee,et al.  Fucoidan from Seaweed Fucus vesiculosus Inhibits Migration and Invasion of Human Lung Cancer Cell via PI3K-Akt-mTOR Pathways , 2012, PloS one.

[5]  T. Zvyagintseva,et al.  ESIMS analysis of fucoidan preparations from Costaria costata, extracted from alga at different life-stages. , 2012, Carbohydrate polymers.

[6]  A. Chang,et al.  Fucoidan extract derived from Undaria pinnatifida inhibits angiogenesis by human umbilical vein endothelial cells. , 2012, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[7]  Q. Song,et al.  Comparison of the effects of marchantin C and fucoidan on sFlt‐1 and angiogenesis in glioma microenvironment , 2012, The Journal of pharmacy and pharmacology.

[8]  T. Zvyagintseva,et al.  Sulfated polysaccharides from brown seaweeds Saccharina japonica and Undaria pinnatifida: isolation, structural characteristics, and antitumor activity. , 2011, Carbohydrate research.

[9]  A. Goyal,et al.  Recent developments in mushrooms as anti-cancer therapeutics: a review , 2011, 3 Biotech.

[10]  A. Meyer,et al.  Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo. , 2011, International journal of biological macromolecules.

[11]  J. Alsac,et al.  Radiolabeled Fucoidan as a P-Selectin Targeting Agent for In Vivo Imaging of Platelet-Rich Thrombus and Endothelial Activation , 2011, The Journal of Nuclear Medicine.

[12]  M. Perc,et al.  Resolution of the Stochastic Strategy Spatial Prisoner's Dilemma by Means of Particle Swarm Optimization , 2011, PloS one.

[13]  B. Um,et al.  Fucoidans from Brown Seaweeds Sargassum hornery, Eclonia cava, Costaria costata: Structural Characteristics and Anticancer Activity , 2011, Applied biochemistry and biotechnology.

[14]  Guangli Yu,et al.  Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae , 2011, Marine drugs.

[15]  Susan Løvstad Holdt,et al.  Bioactive compounds in seaweed: functional food applications and legislation , 2011, Journal of Applied Phycology.

[16]  F. Cappuzzo,et al.  Future scenarios for the treatment of advanced non-small cell lung cancer: focus on taxane-containing regimens. , 2010, The oncologist.

[17]  J. Kwak,et al.  The mechanism of fucoidan‐induced apoptosis in leukemic cells: Involvement of ERK1/2, JNK, glutathione, and nitric oxide , 2010, Molecular carcinogenesis.

[18]  U. Schneider,et al.  Dose-response relationship for lung cancer induction at radiotherapy dose. , 2010, Zeitschrift fur medizinische Physik.

[19]  Quanbin Zhang,et al.  Higher specificity of the activity of low molecular weight fucoidan for thrombin-induced platelet aggregation. , 2010, Thrombosis research.

[20]  Myeong-Jin Kim,et al.  A multiloculated cystic mass in the liver. , 2010, Gastroenterology.

[21]  Yonghong Liu,et al.  Hypolipidemic effect of fucoidan from Laminaria japonica in hyperlipidemic rats , 2010, Pharmaceutical biology.

[22]  T. Tham,et al.  How do patients with inflammatory bowel disease want their biological therapy administered? , 2010, BMC gastroenterology.

[23]  P. G. Deriabin,et al.  [Antiviral activity of sulfated polysaccharide from the brown algae Laminaria japonica against avian influenza A (H5N1) virus infection in the cultured cells]. , 2010, Voprosy virusologii.

[24]  Quanbin Zhang,et al.  Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica. , 2010, International journal of biological macromolecules.

[25]  T. Vanden Berghe,et al.  Major cell death pathways at a glance. , 2009, Microbes and infection.

[26]  J. Hyun,et al.  Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells. , 2009, Biological & pharmaceutical bulletin.

[27]  Koji Yamada,et al.  Fucoidan induces apoptosis through activation of caspase-8 on human breast cancer MCF-7 cells. , 2009, Journal of agricultural and food chemistry.

[28]  E. Schleußner,et al.  mTOR mediates human trophoblast invasion through regulation of matrix-remodeling enzymes and is associated with serine phosphorylation of STAT3. , 2009, Experimental cell research.

[29]  T. Nagamine,et al.  Inhibitory Effect of Fucoidan on Huh7 Hepatoma Cells Through Downregulation of CXCL12 , 2009, Nutrition and cancer.

[30]  T. Nagamine,et al.  Effect of fucoidan on the biotinidase kinetics in human hepatocellular carcinoma. , 2009, Anticancer research.

[31]  F. Chaubet,et al.  Affinity of low molecular weight fucoidan for P-selectin triggers its binding to activated human platelets. , 2009, Biochimica et biophysica acta.

[32]  G. Godeau,et al.  Potential effects of a low-molecular-weight fucoidan extracted from brown algae on bone biomaterial osteoconductive properties. , 2008, Journal of biomedical materials research. Part A.

[33]  Junying Yuan,et al.  Caspases in apoptosis and beyond , 2008, Oncogene.

[34]  M. Bilan,et al.  Structural Analysis of Fucoidans , 2008 .

[35]  Kei Kuratomi,et al.  Fucoidan, a major component of brown seaweed, prohibits the growth of human cancer cell lines in vitro. , 2008, Molecular Medicine Reports.

[36]  E. Braga,et al.  Nutrients removed by Kappaphycus alvarezii (Rhodophyta, Solieriaceae) in integrated cultivation with fishes in re-circulating water , 2008 .

[37]  A. Al Haj Zen,et al.  Effect of Low Molecular Weight Fucoidan and Low Molecular Weight Heparin in a Rabbit Model of Arterial Thrombosis , 2008, Journal of Vascular Research.

[38]  Z. Dong,et al.  Inhibitory effects of fucoidan on activation of epidermal growth factor receptor and cell transformation in JB6 Cl41 cells. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[39]  Toshikazu Nakamura,et al.  Induction of hepatocyte growth factor by fucoidan and fucoidan‐derived oligosaccharides , 2008, The Journal of pharmacy and pharmacology.

[40]  F. Fauvel-Lafève,et al.  Ex Vivo Priming of Endothelial Progenitor Cells With SDF-1 Before Transplantation Could Increase Their Proangiogenic Potential , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[41]  Quanbin Zhang,et al.  Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica. , 2008, International journal of biological macromolecules.

[42]  Chi-Tan Hu,et al.  Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species , 2008, Cancer and Metastasis Reviews.

[43]  P. V. Suresh,et al.  Seaweeds as a source of nutritionally beneficial compounds - A review , 2008 .

[44]  R. Lockshin,et al.  Cell death in health and disease , 2007, Journal of cellular and molecular medicine.

[45]  T. Konishi,et al.  Anti-proliferative activity of oversulfated fucoidan from commercially cultured Cladosiphon okamuranus TOKIDA in U937 cells. , 2007, International journal of biological macromolecules.

[46]  S. Turgeon,et al.  Characterization of polysaccharides extracted from brown seaweeds , 2007 .

[47]  T. Zvyagintseva,et al.  Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk sea Fucus evanescens brown alga , 2007, Bulletin of Experimental Biology and Medicine.

[48]  E. Damonte,et al.  Structural Features and Antiviral Activity of Sulphated Fucans from the Brown Seaweed Cystoseira Indica , 2007, Antiviral chemistry & chemotherapy.

[49]  H. Ahmed,et al.  Clinical Importance and Therapeutic Implications of the Pivotal CXCL12-CXCR4 (Chemokine Ligand-Receptor) Interaction in Cancer Cell Migration , 2007, Tumor Biology.

[50]  R. Davis,et al.  Role of mitogen-activated protein kinase kinase 4 in cancer , 2007, Oncogene.

[51]  Maeve Kelly,et al.  A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. , 2007, Glycobiology.

[52]  W. Zou,et al.  Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis. , 2007, American journal of physiology. Cell physiology.

[53]  Didier Letourneur,et al.  Low Molecular Weight Fucoidan Increases VEGF165-induced Endothelial Cell Migration by Enhancing VEGF165 Binding to VEGFR-2 and NRP1* , 2006, Journal of Biological Chemistry.

[54]  M. Iizuka,et al.  The role of NK cells in antitumor activity of dietary fucoidan from Undaria pinnatifida sporophylls (Mekabu). , 2006, Planta medica.

[55]  S. P. Preetha,et al.  Renal peroxidative changes mediated by oxalate: the protective role of fucoidan. , 2006, Life sciences.

[56]  Li Wang,et al.  [Expression and significance of PTEN/PI3K signal transduction-related proteins in non-small cell lung cancer]. , 2006, Ai zheng = Aizheng = Chinese journal of cancer.

[57]  Teodoro Espinosa-Solares,et al.  Macroscopic mass and energy balance of a pilot plant anaerobic bioreactor operated under thermophilic conditions , 2006, Applied biochemistry and biotechnology.

[58]  G. Godeau,et al.  Fucoidan a sulfated polysaccharide from brown algae is a potent modulator of connective tissue proteolysis. , 2006, Archives of biochemistry and biophysics.

[59]  P. Wright,et al.  The current status of natural products from marine fungi and their potential as anti-infective agents , 2006, Journal of Industrial Microbiology and Biotechnology.

[60]  Quanbin Zhang,et al.  Antioxidant activity of different molecular weight sulfated polysaccharides from Ulva pertusa Kjellm (Chlorophyta) , 2005, Journal of Applied Phycology.

[61]  D. Benisvy,et al.  Low-molecular-weight fucoidan enhances the proangiogenic phenotype of endothelial progenitor cells. , 2005, Biochemical pharmacology.

[62]  Yuetsu Tanaka,et al.  Fucoidan Extracted From Cladosiphon Okamuranus Tokida Induces Apoptosis of Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines and Primary Adult T-Cell Leukemia Cells , 2005, Nutrition and cancer.

[63]  K. Matsubara,et al.  Effects of middle molecular weight fucoidans on in vitro and ex vivo angiogenesis of endothelial cells. , 2005, International journal of molecular medicine.

[64]  Ning Li,et al.  Fucoidan inhibits the development of proteinuria in active Heymann nephritis , 2005, Phytotherapy research : PTR.

[65]  M. Kizaki,et al.  Fucoidan induces apoptosis of human HS‐Sultan cells accompanied by activation of caspase‐3 and down‐regulation of ERK Pathways , 2005, American journal of hematology.

[66]  Y. Katakura,et al.  Enzyme-digested Fucoidan Extracts Derived from Seaweed Mozuku of Cladosiphon novae-caledoniaekylin Inhibit Invasion and Angiogenesis of Tumor Cells , 2005, Cytotechnology.

[67]  E. Fattorusso,et al.  Chemical diversity of bioactive marine natural products: an illustrative case study. , 2004, Current medicinal chemistry.

[68]  Teiji Wada,et al.  Mitogen-activated protein kinases in apoptosis regulation , 2004, Oncogene.

[69]  Henning Walczak,et al.  The interplay between the Bcl-2 family and death receptor-mediated apoptosis. , 2004, Biochimica et biophysica acta.

[70]  C. K. Tseng,et al.  Algal biotechnology industries and research activities in China , 2001, Journal of Applied Phycology.

[71]  Yu Fang,et al.  Antioxidative activities of low molecular fucoidans from kelp laminaria japonica , 2004 .

[72]  Ning Li,et al.  In vivo antioxidant activity of polysaccharide fraction from Porphyra haitanesis (Rhodephyta) in aging mice. , 2003, Pharmacological research.

[73]  O. Berteau,et al.  Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide. , 2003, Glycobiology.

[74]  K. Smalley,et al.  A pivotal role for ERK in the oncogenic behaviour of malignant melanoma? , 2003, International journal of cancer.

[75]  A. Fischer,et al.  Effect of low‐molecular‐weight fucoidan on experimental arterial thrombosis in the rabbit and rat , 2003, Journal of thrombosis and haemostasis : JTH.

[76]  Satoru Koyanagi,et al.  Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities. , 2003, Biochemical pharmacology.

[77]  O. Berteau,et al.  硫酸化フカン,最新の展望 硫酸化フカンの構造,機能,及び生物学的性質とこのクラスの多糖類に対して活性を示す酵素の概要 , 2003 .

[78]  P. Wilairat,et al.  Involvement of ERK1/2 in invasiveness and metastatic development of rat prostatic adenocarcinoma. , 2003, Oncology research.

[79]  M. Karin,et al.  AP-1 as a regulator of cell life and death , 2002, Nature Cell Biology.

[80]  Scott W. Lowe,et al.  Apoptosis A Link between Cancer Genetics and Chemotherapy , 2002, Cell.

[81]  P. Rupérez,et al.  Potential antioxidant capacity of sulfated polysaccharides from the edible marine brown seaweed Fucus vesiculosus. , 2002, Journal of agricultural and food chemistry.

[82]  M. Geng,et al.  An In Vitro Study of the Structure-Activity Relationships of Sulfated Polysaccharide from Brown Algae to its Antioxidant Effect , 2001, Journal of Asian natural products research.

[83]  A. Usov,et al.  [Algae polysaccharides. 55. Polysaccharide composition of some brown Kamchatka algae]. , 2001, Bioorganicheskaia khimiia.

[84]  Masakazu Murata,et al.  Production and use of marine algae in Japan , 2001 .

[85]  Chaohua Yan,et al.  Apoptosis in the absence of caspase 3 , 2001, Oncogene.

[86]  A. Cerezo,et al.  Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum. , 2001, Carbohydrate research.

[87]  M. Karin,et al.  Mammalian MAP kinase signalling cascades , 2001, Nature.

[88]  B. Mulloy,et al.  A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae. , 2001, Carbohydrate research.

[89]  C. Sinquin,et al.  Relationship between sulfate groups and biological activities of fucans. , 2000, Thrombosis research.

[90]  M. Hengartner The biochemistry of apoptosis , 2000, Nature.

[91]  M. Tako,et al.  Chemical Characterization of Acetyl Fucoidan and Alginate from Commercially Cultured Cladosiphon okamuranus , 2000 .

[92]  A. Beaudet,et al.  Mobilization of stem/progenitor cells by sulfated polysaccharides does not require selectin presence. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[93]  H. Erlandsson‐Harris,et al.  Role of selectins in experimental Staphylococcus aureus‐induced arthritis , 2000, European journal of immunology.

[94]  J. Lundgren,et al.  Meningitis in Rabbits during Experimental Pneumococcal Bacterial Load in Cerebrospinal Fluid Inflammatory Response but Not the Colony-stimulating Factor Attenuates the Pretreatment with Granulocyte , 1999 .

[95]  N. Colburn,et al.  Activator protein 1 (AP-1)– and nuclear factor κB (NF-κB)–dependent transcriptional events in carcinogenesis , 2000 .

[96]  J. Martinou,et al.  Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane , 2000, Molecular and Cellular Biology.

[97]  L. Lindquist,et al.  Effects of Polysaccharide Fucoidin on Cerebrospinal Fluid Interleukin-1 and Tumor Necrosis Factor Alpha in Pneumococcal Meningitis in the Rabbit , 1999, Infection and Immunity.

[98]  Jean-Claude Martinou,et al.  Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis , 1999, The Journal of cell biology.

[99]  V. Dixit,et al.  Death receptors: signaling and modulation. , 1998, Science.

[100]  N. Nelson Inhibitors of angiogenesis enter phase III testing. , 1998, Journal of the National Cancer Institute.

[101]  K. Nagahira,et al.  Fucoidin, a potent inhibitor of L-selectin function, reduces contact hypersensitivity reaction in mice. , 1997, Immunology letters.

[102]  S. Bosch,et al.  Antitumor and antiproliferative effects of a fucan extracted from ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line. , 1996, Anticancer research.

[103]  D. Green,et al.  Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl , 1995, The Journal of experimental medicine.

[104]  H. Itoh,et al.  Immunological analysis of inhibition of lung metastases by fucoidan (GIV-A) prepared from brown seaweed Sargassum thunbergii. , 1995, Anticancer research.

[105]  T. Mizuno,et al.  Antitumor active fucoidan from the brown seaweed, umitoranoo (Sargassum thunbergii). , 1995, Bioscience, biotechnology, and biochemistry.

[106]  J. Folkman Angiogenesis in cancer, vascular, rheumatoid and other disease , 1995, Nature Medicine.

[107]  R. Williams,et al.  A revised structure for fucoidan may explain some of its biological activities. , 1993, The Journal of biological chemistry.

[108]  N. Davidson,et al.  Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. , 1993, Cancer research.

[109]  P. Nurse,et al.  Animal cell cycles and their control. , 1992, Annual review of biochemistry.

[110]  T. Nishino,et al.  The sulfate-content dependence of the anticoagulant activity of a fucan sulfate from the brown seaweed Ecklonia kurome. , 1991, Carbohydrate research.

[111]  M. Klagsbrun,et al.  Regulators of angiogenesis. , 1991, Annual review of physiology.

[112]  D. McHugh Production and utilization of products from commercial seaweeds , 1987 .

[113]  H. Mori,et al.  Antitumor effect of seaweeds. IV. Enhancement of antitumor activity by sulfation of a crude fucoidan fraction from Sargassum kjellmanianum. , 1984, The Japanese journal of experimental medicine.

[114]  H. Tuppy,et al.  Hoppe-Seyler's zeitschrift fur physiologische chemie , 1977 .

[115]  C. Araki Chemistry and enzymology of marine algal polysaccharides , 1969 .

[116]  A. Dieffenbacher,et al.  Arteriosclerosis , 1925, The Indian Medical Gazette.

[117]  H. Kylin Zur Biochemie der Meeresalgen. , 1913 .