Male and Female Drosophila Germline Stem Cells: Two Versions of Immortality

Drosophila male and female germline stem cells (GSCs) are sustained by niches and regulatory pathways whose common principles serve as models for understanding mammalian stem cells. Despite striking cellular and genetic similarities that suggest a common evolutionary origin, however, male and female GSCs also display important differences. Comparing these two stem cells and their niches in detail is likely to reveal how a common heritage has been adapted to the differing requirements of male and female gamete production.

[1]  A. Spradling,et al.  Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries , 2004, Nature.

[2]  M. Clarke,et al.  Stem Cells and Cancer: Two Faces of Eve , 2006, Cell.

[3]  Linheng Li,et al.  Stem cell niche: structure and function. , 2005, Annual review of cell and developmental biology.

[4]  A. Mahowald,et al.  Asymmetric Inheritance of Mother Versus Daughter Centrosome in Stem Cell Division , 2007, Science.

[5]  A. Spradling,et al.  A niche maintaining germ line stem cells in the Drosophila ovary. , 2000, Science.

[6]  R. Lehmann,et al.  Repression of Primordial Germ Cell Differentiation Parallels Germ Line Stem Cell Maintenance , 2004, Current Biology.

[7]  A. Kiger,et al.  Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue , 2001, Science.

[8]  A. Spradling,et al.  The Drosophila ovarian and testis stem cell niches: similar somatic stem cells and signals. , 2005, Developmental cell.

[9]  S. Tazuke,et al.  Signaling from germ cells mediated by the rhomboid homolog stet organizes encapsulation by somatic support cells. , 2002, Development.

[10]  Y. Nabeshima,et al.  Functional identification of the actual and potential stem cell compartments in mouse spermatogenesis. , 2007, Developmental cell.

[11]  Yukiko M Yamashita,et al.  Signaling in stem cell niches: lessons from the Drosophila germline , 2005, Journal of Cell Science.

[12]  M. Casanueva,et al.  Germline stem cell number in the Drosophila ovary is regulated by redundant mechanisms that control Dpp signaling , 2004, Development.

[13]  E. Matunis,et al.  Regeneration of Male Germline Stem Cells by Spermatogonial Dedifferentiation in Vivo , 2004, Science.

[14]  R. Brinster.  Male Germline Stem Cells: From Mice to Men , 2007, Science.

[15]  A. Kiger,et al.  A Misexpression Screen Reveals Effects of bag-of-marbles and TGFβ Class Signaling on the Drosophila Male Germ-Line Stem Cell Lineage , 2004, Genetics.

[16]  E. Matunis,et al.  Control of Stem Cell Self-Renewal in Drosophila Spermatogenesis by JAK-STAT Signaling , 2001, Science.

[17]  Dahua Chen,et al.  Dpp Signaling Silences bam Transcription Directly to Establish Asymmetric Divisions of Germline Stem Cells , 2003, Current Biology.