A chimeric live attenuated vaccine against Japanese encephalitis

Japanese encephalitis is a disease of the CNS, endemic in Asia and Oceania. The disease is refractory to drug treatments and whilst the rural economies remain heavily dependent on agriculture, conditions for propagation of the disease will persist. Thus, there is a need for effective vaccines. Although some currently exist, they have their shortcomings. ChimeriVax™-JE (Acambis Inc.) is a chimeric, live attenuated vaccine which expresses protective Japanese encephalitis antigens and to date has proven to be safe, effective and well-tolerated in clinical trials. It therefore appears to be a cost-effective prophylactic vaccine against this debilitating disease.

[1]  E. Hindle.  Yellow fever vaccine , 1928, Reactions Weekly.

[2]  F. Guirakhoo,et al.  Chimeric live, attenuated vaccine against Japanese encephalitis (ChimeriVax-JE): phase 2 clinical trials for safety and immunogenicity, effect of vaccine dose and schedule, and memory response to challenge with inactivated Japanese encephalitis antigen. , 2003, The Journal of infectious diseases.

[3]  E. Konishi,et al.  Immunogenicity of a Japanese encephalitis DNA vaccine candidate in cynomolgus monkeys. , 2003, Vaccine.

[4]  F. Guirakhoo,et al.  Traditional and novel approaches to flavivirus vaccines. , 2003, International journal for parasitology.

[5]  H. Guzmán,et al.  Efficacy of Killed Virus Vaccine, Live Attenuated Chimeric Virus Vaccine, and Passive Immunization for Prevention of West Nile virus Encephalitis in Hamster Model , 2002, Emerging infectious diseases.

[6]  I. Zhulin,et al.  Positional cloning of the murine flavivirus resistance gene , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[7]  F. Guirakhoo,et al.  Viremia and immunogenicity in nonhuman primates of a tetravalent yellow fever-dengue chimeric vaccine: genetic reconstructions, dose adjustment, and antibody responses against wild-type dengue virus isolates. , 2002, Virology.

[8]  F. Guirakhoo,et al.  Clinical proof of principle for ChimeriVax: recombinant live, attenuated vaccines against flavivirus infections. , 2002, Vaccine.

[9]  A. Nisalak,et al.  Japanese encephalitis virus: ecology and epidemiology. , 2002, Current topics in microbiology and immunology.

[10]  GWONG‐JEN J. Chang,et al.  Flavivirus DNA Vaccines , 2001 .

[11]  A. Barrett.  Current Status of Flavivirus Vaccines , 2001, Annals of the New York Academy of Sciences.

[12]  D. Vaughn,et al.  A purified inactivated Japanese encephalitis virus vaccine made in Vero cells. , 2001, Vaccine.

[13]  T. Solomon,et al.  Dengue and other emerging flaviviruses. , 2001, The Journal of infection.

[14]  F. Guirakhoo,et al.  West Nile virus vaccine. , 2001, Current drug targets. Infectious disorders.

[15]  G. Kuno,et al.  Flavivirus DNA vaccines: current status and potential. , 2001, Annals of the New York Academy of Sciences.

[16]  E. Konishi,et al.  Safety and immunogenicity of NYVAC-JEV and ALVAC-JEV attenuated recombinant Japanese encephalitis virus--poxvirus vaccines in vaccinia-nonimmune and vaccinia-immune humans. , 2000, Vaccine.

[17]  F. Guirakhoo,et al.  Recombinant Chimeric Yellow Fever-Dengue Type 2 Virus Is Immunogenic and Protective in Nonhuman Primates , 2000, Journal of Virology.

[18]  A. Barrett,et al.  Chimeric Yellow Fever Virus 17D-Japanese Encephalitis Virus Vaccine: Dose-Response Effectiveness and Extended Safety Testing in Rhesus Monkeys , 2000, Journal of Virology.

[19]  A. Barrett,et al.  Immunogenicity, genetic stability, and protective efficacy of a recombinant, chimeric yellow fever-Japanese encephalitis virus (ChimeriVax-JE) as a live, attenuated vaccine candidate against Japanese encephalitis. , 1999, Virology.

[20]  A. Barrett,et al.  Recombinant, chimaeric live, attenuated vaccine (ChimeriVax) incorporating the envelope genes of Japanese encephalitis (SA14-14-2) virus and the capsid and nonstructural genes of yellow fever (17D) virus is safe, immunogenic and protective in non-human primates. , 1999, Vaccine.

[21]  C. Rice,et al.  Yellow Fever/Japanese Encephalitis Chimeric Viruses: Construction and Biological Properties , 1999, Journal of Virology.

[22]  R. Reuben,et al.  Development of combined use of neem (Azadirachta indica) and water management for the control of culicine mosquitoes in rice fields , 1995, Medical and veterinary entomology.

[23]  N. Begg,et al.  Systemic allergic reactions to Japanese encephalitis vaccines. , 1994, Vaccine.

[24]  Gubler Mackenzie JS.  Japanese Encephalitis Vaccines ; WHO Position Paper Aug 2006 : Selected references Epidemiology of Japanese Encephalitis , 2022 .