Curcumin Protects Against the Age-related Hearing Loss by Attenuating Apoptosis and Senescence via Activating Nrf2 Signaling in Cochlear Hair Cells

[1]  Erin M. Picou Hearing Aid Benefit and Satisfaction Results from the MarkeTrak 2022 Survey: Importance of Features and Hearing Care Professionals , 2022, Seminars in Hearing.

[2]  Jeff Choi,et al.  Associations of Hearing Loss Severity and Hearing Aid Use With Hospitalization Among Older US Adults. , 2022, JAMA otolaryngology-- head & neck surgery.

[3]  S. Lai,et al.  Curcumin activates Nrf2/HO‐1 signaling to relieve diabetic cardiomyopathy injury by reducing ROS in vitro and in vivo , 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[4]  K. Abe,et al.  Protective and anti-oxidative effects of curcumin and resveratrol on Aβ-oligomer-induced damage in the SH-SY5Y cell line , 2022, Journal of the Neurological Sciences.

[5]  Beatriz de Lucas,et al.  Preventive Effect of Cocoa Flavonoids via Suppression of Oxidative Stress-Induced Apoptosis in Auditory Senescent Cells , 2022, Antioxidants.

[6]  Xiaowan Wang,et al.  Curcumin Alleviates D-Galactose-Induced Cardiomyocyte Senescence by Promoting Autophagy via the SIRT1/AMPK/mTOR Pathway , 2022, Evidence-based complementary and alternative medicine : eCAM.

[7]  Biao Chen,et al.  Protective Effects of Vitamin C against Neomycin-Induced Apoptosis in HEI-OC1 Auditory Cell , 2022, Neural plasticity.

[8]  K. Beisel,et al.  Molecular and cytological profiling of biological aging of mouse cochlear inner and outer hair cells , 2022, Cell reports.

[9]  H. Khan,et al.  Nrf2 Regulation by Curcumin: Molecular Aspects for Therapeutic Prospects , 2021, Molecules.

[10]  T. Muderris,et al.  Efficiency of resveratrol in the prevention and treatment of age‑related hearing loss , 2021, Experimental and Therapeutic Medicine.

[11]  A. Cuadrado Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases. , 2021, Annual review of pharmacology and toxicology.

[12]  Y. Cho,et al.  Sodium‐glucose cotransporter‐2 inhibition reduces cellular senescence in the diabetic kidney by promoting ketone body‐induced NRF2 activation , 2021, Diabetes, obesity & metabolism.

[13]  Yanzhuo Zhang,et al.  PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway , 2021, Oxidative medicine and cellular longevity.

[14]  P. Jat,et al.  Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype , 2021, Frontiers in Cell and Developmental Biology.

[15]  C. Lyketsos,et al.  Association of Hearing Loss With Neuropsychiatric Symptoms in Older Adults With Cognitive Impairment. , 2020, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[16]  A. Jovanovic,et al.  Cardioprotection by isosteviol derivate JC105: A unique drug property to activate ERK1/2 only when cells are exposed to hypoxia‐reoxygenation , 2020, Journal of cellular and molecular medicine.

[17]  Theodore R. McRackan,et al.  Assessment of Hearing Aid Benefit Using Patient-Reported Outcomes and Audiologic Measures , 2020, Audiology and Neurotology.

[18]  R. Bennett,et al.  Investigating the prevalence and impact of device-related problems associated with hearing aid use , 2020, International journal of audiology.

[19]  K. Krause,et al.  Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss , 2020, Redox biology.

[20]  T. Takata,et al.  Visfatin Induces Senescence of Human Dental Pulp Cells , 2020, Cells.

[21]  B. Kolb,et al.  Age-related hearing loss and tinnitus, dementia risk, and auditory amplification outcomes , 2019, Ageing Research Reviews.

[22]  R. Chai,et al.  Cochlear Surface Preparation in the Adult Mouse. , 2019, Journal of visualized experiments : JoVE.

[23]  R. Park,et al.  Augmentation of cellular NAD+ by NQO1 enzymatic action improves age‐related hearing impairment , 2019, Aging cell.

[24]  M. Bergo,et al.  BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis , 2019, Cell.

[25]  T. Irino,et al.  Rising-frequency chirp stimulus to effectively enhance wave-I amplitude of auditory brainstem response , 2019, Hearing Research.

[26]  Andy Wai Kan Yeung,et al.  Curcumin: Total-Scale Analysis of the Scientific Literature , 2019, Molecules.

[27]  A. Ishiyama,et al.  Immunohistochemical localization of Nrf2 in the human cochlea , 2018, Brain Research.

[28]  Michael E. Smith,et al.  The curcuminoid, EF-24, reduces cisplatin-mediated reactive oxygen species in zebrafish inner ear auditory and vestibular tissues , 2018, Journal of Clinical Neuroscience.

[29]  J. Meunier,et al.  N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model , 2018, Aging and disease.

[30]  B. McKinnon,et al.  Hearing Loss in the Elderly. , 2018, Clinics in geriatric medicine.

[31]  Wenxuan Xu,et al.  Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[32]  R. Frisina,et al.  Chronic inflammation – inflammaging – in the ageing cochlea: A novel target for future presbycusis therapy , 2017, Ageing Research Reviews.

[33]  M. Ding,et al.  Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors. , 2017, European cells & materials.

[34]  C. Chen,et al.  NLRX1 accelerates cisplatin-induced ototoxity in HEI-OC1 cells via promoting generation of ROS and activation of JNK signaling pathway , 2017, Scientific Reports.

[35]  R. Frisina,et al.  Age-related hearing loss: prevention of threshold declines, cell loss and apoptosis in spiral ganglion neurons , 2016, Aging.

[36]  P. Reddy,et al.  Protective effects of a natural product, curcumin, against amyloid β induced mitochondrial and synaptic toxicities in Alzheimer's disease , 2016, Journal of Investigative Medicine.

[37]  H. Jung,et al.  The effects of the antioxidant α-tocopherol succinate on cisplatin-induced ototoxicity in HEI-OC1 auditory cells. , 2016, International journal of pediatric otorhinolaryngology.

[38]  Channy Park,et al.  HEI-OC1 cells as a model for investigating drug cytotoxicity , 2016, Hearing Research.

[39]  Suprapto Ma’at,et al.  Curcumin Reduces the Noise-Exposed Cochlear Fibroblasts Apoptosis , 2016, International Archives of Otorhinolaryngology.

[40]  H. Forman,et al.  Introduction to Special Issue on 'Nrf2 Regulated Redox Signaling and Metabolism in Physiology and Medicine. , 2015, Free radical biology & medicine.

[41]  A. Fetoni,et al.  Rosmarinic acid up-regulates the noise-activated Nrf2/HO-1 pathway and protects against noise-induced injury in rat cochlea. , 2015, Free radical biology & medicine.

[42]  C. Meshul,et al.  Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic Mice , 2015, PloS one.

[43]  Xiao-tong Zhang,et al.  Ginkgolide B protects against cisplatin-induced ototoxicity: enhancement of Akt–Nrf2–HO-1 signaling and reduction of NADPH oxidase , 2015, Cancer Chemotherapy and Pharmacology.

[44]  C. Fujimoto,et al.  Oxidative Stresses and Mitochondrial Dysfunction in Age-Related Hearing Loss , 2014, Oxidative medicine and cellular longevity.

[45]  T. Yamasoba,et al.  Current concepts in age-related hearing loss: Epidemiology and mechanistic pathways , 2013, Hearing Research.

[46]  P. Talalay,et al.  Sulforaphane accelerates acetaldehyde metabolism by inducing aldehyde dehydrogenases: relevance to ethanol intolerance. , 2013, Alcohol and alcoholism.

[47]  Cheng-I Lee,et al.  Curcumin Reduces Amyloid Fibrillation of Prion Protein and Decreases Reactive Oxidative Stress , 2013, Pathogens.

[48]  M. Mishra,et al.  Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy. , 2013, Investigative ophthalmology & visual science.

[49]  Heather Fortnum,et al.  Why do people fitted with hearing aids not wear them? , 2013, International journal of audiology.

[50]  Y. Keum Regulation of Nrf2-Mediated Phase II Detoxification and Anti-oxidant Genes , 2012, Biomolecules & therapeutics.

[51]  Y. Li,et al.  Protective effects of curcumin in APPswe transfected SH-SY5Y cells , 2012, Neural regeneration research.

[52]  Christophe B. Michel,et al.  Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea. , 2012, Antioxidants & redox signaling.

[53]  Masayuki Yamamoto,et al.  Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity. , 2011, Biochemical and biophysical research communications.

[54]  Barbara Majello,et al.  Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression , 2011, Nucleic acids research.

[55]  Paul Mitchell,et al.  Use of hearing AIDS and assistive listening devices in an older Australian population. , 2010, Journal of the American Academy of Audiology.

[56]  Shakir Ali,et al.  Nrf2/HO-1 signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene. , 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[57]  R. Shukla,et al.  Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow. , 2010, Life sciences.

[58]  A. Ishigami,et al.  Effect of vitamin C depletion on age-related hearing loss in SMP30/GNL knockout mice. , 2009, Biochemical and biophysical research communications.

[59]  Richard Weindruch,et al.  Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis , 2009, Proceedings of the National Academy of Sciences.

[60]  B. Hyman,et al.  Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model , 2007, Journal of neurochemistry.

[61]  Barbara Canlon,et al.  N-Acetyl l-cysteine does not protect against premature age-related hearing loss in C57BL/6J mice: A pilot study , 2007, Hearing Research.

[62]  Erik G Nelson,et al.  Presbycusis: A Human Temporal Bone Study of Individuals With Downward Sloping Audiometric Patterns of Hearing Loss and Review of the Literature , 2006, The Laryngoscope.

[63]  Robert S. Balaban,et al.  Mitochondria, Oxidants, and Aging , 2005, Cell.

[64]  Fusheng Yang,et al.  Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo* , 2005, Journal of Biological Chemistry.

[65]  B. May,et al.  The functional age of hearing loss in a mouse model of presbycusis. I. Behavioral assessments , 2003, Hearing Research.

[66]  P. Fuchs,et al.  The afferent synapse of cochlear hair cells , 2003, Current Opinion in Neurobiology.

[67]  M. Charles Liberman,et al.  Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier , 2002, Nature.

[68]  A. Sahebkar,et al.  Turmeric and Curcumin: From Traditional to Modern Medicine. , 2021, Advances in experimental medicine and biology.

[69]  S. Griest,et al.  Auditory Brainstem Response Altered in Humans With Noise Exposure Despite Normal Outer Hair Cell Function , 2017, Ear and hearing.

[70]  E Borg,et al.  Age-related loss of auditory sensitivity in two mouse genotypes. , 1991, Acta oto-laryngologica.