SIRT 1 deacetylase protects against neurodegeneration in models for Alzheimer ’ s disease and amyotrophic lateral sclerosis

Dohoon Kim, Minh Dang Nguyen, Matthew M Dobbin, Andre Fischer, Farahnaz Sananbenesi, Joseph T Rodgers, Ivana Delalle, Joseph A Baur, Guangchao Sui, Sean M Armour, Pere Puigserver, David A Sinclair* and Li-Huei Tsai* Howard Hughes Medical Institute, Picower Insitute for Learning and Memory, Riken-MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Boston, MA, USA, Division of Medical Sciences, Harvard Medical School, Boston, MA, USA, Department of Pathology, Harvard Medical School, Boston, MA, USA, Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA, USA, Department of Cell Biology, Johns Hopkins University School of Medicine, Boston, MA, USA and Department of Pathology and Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA, USA

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