Analysis of heat transfer in deformed liver cancer modeling treated using a microwave coaxial antenna

In interstitial microwave ablation (MWA), cancer is treated by applying localized heating to the tumor tissue. Some of the challenges associated with the selective heating of cancer cells, without damaging the surrounding tissue, entail a control of heating power for appropriate temperature distribution. This paper is carried out on the computer simulation of liver cancer treated using a microwave coaxial antenna (MCA). The mathematical models consist of a coupled electromagnetic wave equation, bioheat equation and mechanical deformation equation. In numerical simulation, these coupled mathematical models are solved by using an axisymmetric finite element method (FEM) with temperature dependent thermal and dielectric properties to describe the microwave power absorbed, specific absorption rate (SAR) distribution, temperature distribution and strain distribution in liver tissue. The comparison of the simulated results in model with and without deformation is also considered in order to approach realistic tissue modeling. The results show that the model with deformation, which is the more accurate way to simulate the physical characteristics of therapeutic liver cancer compared to the literature results and hence leads to more useful in the medical approach.

[1]  H. Arkin,et al.  Recent developments in modeling heat transfer in blood perfused tissues , 1994, IEEE Transactions on Biomedical Engineering.

[2]  J. McGahan,et al.  Hepatic ablation with use of radio-frequency electrocautery in the animal model. , 1992, Journal of vascular and interventional radiology : JVIR.

[3]  John G. Webster,et al.  Expanding the Bioheat Equation to Include Tissue Internal Water Evaporation During Heating , 2007, IEEE Transactions on Biomedical Engineering.

[4]  C P Lau,et al.  The Effects of Radiofrequency Ablation Versus Medical Therapy on the Quality‐of‐Life and Exercise Capacity in Patients with Accessory Pathway‐Mediated Supraventricular Tachycardia: A Treatment Comparison Study , 1995, Pacing and clinical electrophysiology : PACE.

[5]  Christopher L. Brace,et al.  Temperature-dependent dielectric properties of liver tissue measured during thermal ablation: Toward an improved numerical model , 2008, 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[6]  M. Abdelghani-Idrissi Experimental investigations of occupied volume effect on the microwave heating and drying kinetics of cement powder in a mono-mode cavity , 2001 .

[7]  Maximilian F. Reiser,et al.  Percutaneous tumor ablation in medical radiology , 2008 .

[8]  Koichi Ito,et al.  A proposition on improvement of a heating pattern of an antenna for microwave coagulation therapy: Introduction of a coaxial‐dipole antenna , 2003 .

[9]  Hong Cao,et al.  Three-dimensional finite-element analyses for radio-frequency hepatic tumor ablation , 2002, IEEE Trans. Biomed. Eng..

[10]  Tanmay Basak,et al.  Microwave driven convection in a rotating cylindrical cavity: A numerical study , 2007 .

[11]  Jun Zhang,et al.  Modeling and numerical simulation of bioheat transfer and biomechanics in soft tissue , 2005, Math. Comput. Model..

[12]  Paul R Stauffer,et al.  Can we settle with single-band radiometric temperature monitoring during hyperthermia treatment of chestwall recurrence of breast cancer using a dual-mode transceiving applicator? , 2007, Physics in medicine and biology.

[13]  Simulation of heat transfer of biological tissue during cryosurgery based on vascular trees , 2009 .

[14]  P. Rattanadecho,et al.  Design and analysis of the commercialized drier processing using a combined unsymmetrical double-feed microwave and vacuum system (case study: tea leaves) , 2010 .

[15]  H. H. Penns Analysis of tissue and arterial blood temperatures in the resting human forearm , 1948 .

[16]  J. Lienhard A heat transfer textbook , 1981 .

[17]  S Nahum Goldberg,et al.  Microwave ablation: results with a 2.45-GHz applicator in ex vivo bovine and in vivo porcine liver. , 2006, Radiology.

[18]  Jonathan W. Valvano,et al.  Thermal conductivity and diffusivity of biomaterials measured with self-heated thermistors , 1985 .

[19]  O. Fujiwara,et al.  FDTD-derived correlation of maximum temperature increase and peak SAR in child and adult head models due to dipole antenna , 2006, IEEE Transactions on Electromagnetic Compatibility.

[20]  K. Seffen,et al.  Skin biothermomechanics for medical treatments. , 2008, Journal of the mechanical behavior of biomedical materials.

[21]  John G. Webster,et al.  A floating sleeve antenna yields localized hepatic microwave ablation , 2006, IEEE Transactions on Biomedical Engineering.

[22]  Phadungsak Rattanadecho,et al.  An analysis of heat transfer in liver tissue during microwave ablation using single and double slot antenna , 2011 .

[23]  L. Leija,et al.  Coaxial Double Slot Antenna Design for Interstitial Hyperthermia in Muscle Using a Finite Element Computer Modeling , 2008, 2008 IEEE Instrumentation and Measurement Technology Conference.

[24]  P. Rattanadecho,et al.  Numerical Analysis of Specific Absorption Rate and Heat Transfer in the Human Body Exposed to Leakage Electromagnetic Field at 915 MHz and 2450 MHz , 2011 .

[25]  P. Rattanadecho,et al.  Experimental and Numerical Analysis of Microwave Heating of Water and Oil Using a Rectangular Wave Guide: Influence of Sample Sizes, Positions, and Microwave Power , 2011 .

[26]  Kazuo Aoki,et al.  The characteristics of microwave melting of frozen packed beds using a rectangular waveguide , 2002 .

[27]  P. J. Hoopes,et al.  Ultrasound Monitoring of a Novel Microwave Ablation (MWA) Device in Porcine Liver: Lessons Learned and Phenomena Observed on Ablative Effects Near Major Intrahepatic Vessels , 2009, Journal of Gastrointestinal Surgery.

[28]  R. Eberhart,et al.  Heat Transfer in Medicine and Biology , 2012 .

[29]  B. Rubinsky Thermal Stresses During Solidification Processes , 1982 .

[30]  Phadungsak Rattanadecho,et al.  The effects of dielectric shield on specific absorption rate and heat transfer in the human body exposed to leakage microwave energy , 2011 .

[31]  Y Rabin,et al.  Numerical solution of the multidimensional freezing problem during cryosurgery. , 1998, Journal of biomechanical engineering.

[32]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[33]  S. Chou,et al.  On the study of the freeze–thaw thermal process of a biological system , 2009 .

[34]  M. Margaliot,et al.  Core temperature measurement by microwave radiometry , 2004 .

[35]  Deshan Yang,et al.  Antenna design for microwave hepatic ablation using an axisymmetric electromagnetic model , 2006, Biomedical engineering online.

[36]  J. McGahan,et al.  Radiofrequency ablation of the liver: current status. , 2001, AJR. American journal of roentgenology.

[37]  Shigenao Maruyama,et al.  Dimensionless solutions and general characteristics of bioheat transfer during thermal therapy , 2009, 1904.07364.

[38]  Kazuo Aoki,et al.  Influence of Irradiation Time, Particle Sizes, and Initial Moisture Content During Microwave Drying of Multi-Layered Capillary Porous Materials , 2002 .

[39]  E. Wissler,et al.  Pennes' 1948 paper revisited. , 1998, Journal of applied physiology.

[40]  W. Lau,et al.  Percutaneous Local Ablative Therapy for Hepatocellular Carcinoma: A Review and Look Into the Future , 2003, Annals of surgery.