Morphologic relationship among the corpus callosum, fornix, anterior commissure, and posterior commissure MRI-based variability study.

RATIONALE AND OBJECTIVES This study explores morphological relationships and structural variability of the corpus callosum (CC), fornix (Fo), anterior (AC), and posterior commissures (PC). MATERIALS AND METHODS These structures are extracted automatically on the midsagittal plane. The CC and Fo are modeled using best-fit ellipses. The parameters characterizing these structures and relationships among them are points, distances, angles, and eccentricities. The minimum, maximum and mean values, standard deviations, and coefficients of variation for all parameters are calculated for 62 diversified MRI datasets. Subsequently, the regression analysis and parameter distribution study are performed. RESULTS The parameters have at least 10% variations. The major axis of CC and eccentricities of CC and Fo vary much less than the other parameters The major axis of CC is approximately parallel to the AC-PC line. The mean eccentricity of each of CC and Fo is greater than 0.95. The most significant correlation (P < .05) is observed between various angles and the angle between the major axes of CC and Fo. The correlation is also significant between other angles and distances. The Weibull distribution characterizes the major axis of CC, and distance between the AC and the most superior point of CC. Distribution of angle between the major axes of CC and Fo is log (logistic), and normal for the AC-PC distance. CONCLUSIONS The AC-PC distance, used prevalently for brain normalization, is not correlated with any parameters except with the distance between the AC and the most superior point on the body of the CC with P < .05.