Thrombolysis in Myocardial Infarction (TI Hemorrhagic Manifestations and Changes in Plasma Fibrinogen an the Fibrinolytic System in Patients Treated With Recomb~ant Tissue Ptasminogen Activator and Streptokinase

prmehtcd lrsulusiaas ,22% r&PA. 2d% strqltoktnssp, were cwnpnbk in bath @cups. More tban 70% of bkedbtg epkoda lo eprh group orc”med at catbete,imUon or vaxular punchwe sitea. Precipitabk Pbrbtaxj+n kvels, measured in pleana sampks calk&d in tbe prance of a protw bddbitw @protinb,,, declined b, *-PA and streptd&w groups by ~~~26pad~%.tlbnndby33rad58%nt5h, mp&iveIy (rt.PA versus strcptctbmw, p < 0.001). At 5 h tb+ pllwnn pksmi,,oge~ declbwd by 57% (r&PA) and 62% (strep(okiwe) (p c 0.001); pianos tibrbdwn) degada induced by stnptotcinssc. Tbe high frequency at bkeding encounteRd is r&ted to tbe pmtacot used, including vigorous sntiroaguktkn. pltninl puctures aed tbroabatytie dwapy. Tbcw findings empb=ke lb+ wed Tar avoinumofiwanvepradwesar.d Formetkulwrcarek the wkctkn an9 management of ptkals sub&&d to tbrwnbdytir t&spy. u AnI Cdl Cwdiol1988;11:1-11)