Increased prevalence of celiac disease in patients with unexplained infertility in the United States

OBJECTIVE To determine whether there might be an increased prevalence of undiagnosed celiac disease among a population of infertile women using serologic screening. STUDY DESIGN A prospective cohort study was performed at an academic infertility clinic in the United States. RESULTS The overall prevalence of celiac disease in this population was 2.1% (4/188). There was a significantly increased prevalence (5.9%) of undiagnosed celiac disease among women presenting with unexplained infertility (n = 51). CONCLUSION Women with unexplained infertility are at increased risk for having undiagnosed celiac disease, which may be a potentially modifiable (and treatable) risk factor.

[1]  G. Meloni,et al.  The prevalence of coeliac disease in infertility. , 1999, Human reproduction.

[2]  G. Oberhuber,et al.  Histopathology of celiac disease. , 2000, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[3]  A. Gasbarrini,et al.  Recurrent spontaneous abortion and intrauterine fetal growth retardation as symptoms of coeliac disease , 2000, The Lancet.

[4]  I. Roberts-Thomson,et al.  Prevalence of celiac disease in the Asia–Pacific region , 2009, Journal of gastroenterology and hepatology.

[5]  D. Moher,et al.  The diagnostic accuracy of serologic tests for celiac disease: a systematic review. , 2005, Gastroenterology.

[6]  M. Croughan,et al.  Prevalence of celiac disease in a cohort of women with unexplained infertility. , 2008, Fertility and sterility.

[7]  J. Murray,et al.  Prevalence of Celiac Disease in At-Risk and Not-At-Risk Groups in the United States , 2003 .

[8]  J. Ludvigsson,et al.  Celiac disease and risk of adverse fetal outcome: a population-based cohort study. , 2005, Gastroenterology.

[9]  P. Pikkarainen,et al.  Infertility and coeliac disease. , 1996, Gut.

[10]  R. Prato,et al.  Reproductive life disorders in Italian celiac women. A case-control study , 2010, BMC gastroenterology.

[11]  M. Liberati,et al.  Serological testing for celiac disease in women undergoing assisted reproduction techniques. , 2006, Human reproduction.

[12]  J. Mayberry,et al.  Female fertility, obstetric and gynaecological history in coeliac disease. A case control study. , 1994, Digestion.

[13]  D. Nicholls,et al.  Adult coeliac disease presenting with infertility. , 1988, Ulster medical journal.

[14]  R. Shamir,et al.  Infertility and celiac disease: do we need more than one serological marker? , 2004, Acta obstetricia et gynecologica Scandinavica.

[15]  F. Granath,et al.  Small-intestinal histopathology and mortality risk in celiac disease. , 2009, JAMA.

[16]  J. Murray,et al.  Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. , 2003, Archives of internal medicine.

[17]  G. Corazza,et al.  Coeliac disease , 2005, Journal of Clinical Pathology.

[18]  C. Cellier,et al.  Celiac disease. , 2007, The New England journal of medicine.

[19]  M. Selimoğlu,et al.  Coeliac disease and reproductive disorders , 2010, Scandinavian journal of gastroenterology.

[20]  R. Ferguson,et al.  Coeliac disease, fertility, and pregnancy. , 1982, Scandinavian journal of gastroenterology.

[21]  R. Ferriani,et al.  Serological testing for celiac disease in women with endometriosis. A pilot study. , 2009, Clinical and experimental obstetrics & gynecology.

[22]  B. Thapa,et al.  Indian task force for celiac disease: current status. , 2009, World journal of gastroenterology.

[23]  L. Kotze,et al.  Gynecologic and Obstetric Findings Related to Nutritional Status and Adherence to a Gluten-Free Diet in Brazilian Patients with Celiac Disease , 2004, Journal of clinical gastroenterology.

[24]  D. Sanders,et al.  Association of adult coeliac disease with irritable bowel syndrome: a case-control study in patients fulfilling ROME II criteria referred to secondary care , 2001, The Lancet.

[25]  H. Sørensen,et al.  Birth outcomes of women with celiac disease: a nationwide historical cohort study , 1999, American Journal of Gastroenterology.

[26]  B. Spiegel,et al.  Testing for celiac sprue in irritable bowel syndrome with predominant diarrhea: a cost-effectiveness analysis. , 2004, Gastroenterology.