New tolfenamic acid derivatives with hydrazine-1-carbothioamide and 1,3,4-oxadiazole moieties targeting VEGFR: synthesis, in silico studies, and in vitro anticancer assessment

[1]  Ammar A. Razzak Mahmood,et al.  Design, Synthesis, and Molecular Docking Studies of 5‐Bromoindole‐2‐Carboxylic Acid Hydrazone Derivatives: In Vitro Anticancer and VEGFR‐2 Inhibitory Effects , 2022, ChemistrySelect.

[2]  G. Batiha,et al.  Computational Study of the Phytochemical Constituents from Uncaria tomentosa Stem Bark against SARS-CoV-2 Omicron Spike Protein , 2022, Journal of Chemistry.

[3]  L. Tahtamouni,et al.  Synthesis, docking study, and structure activity relationship of novel anti-tumor 1, 2, 4 triazole derivatives incorporating 2-(2, 3- dimethyl aminobenzoic acid) moiety , 2022, Pharmacia.

[4]  Abdulrahman M. Saleh,et al.  Synthesis, spectroscopic, anti-bacterial activity, molecular docking,ADMET, Toxicity, and DNA binding studies of divalent metal complexes of pyrazole-3-one azo ligand , 2022, Journal of Molecular Structure.

[5]  I. Eissa,et al.  Ligand and Structure-Based In Silico Determination of the Most Promising SARS-CoV-2 nsp16-nsp10 2′-o-Methyltransferase Complex Inhibitors among 3009 FDA Approved Drugs , 2022, Molecules.

[6]  J. Simal-Gándara,et al.  Integrated Machine Learning and Chemoinformatics-Based Screening of Mycotic Compounds against Kinesin Spindle ProteinEg5 for Lung Cancer Therapy , 2022, Molecules.

[7]  L. Tahtamouni,et al.  A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity , 2021, Pharmacia.

[8]  M. Elsohly,et al.  Discovery of new quinoxaline-2(1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation. , 2021, Bioorganic chemistry.

[9]  Ammar I. Al-Bayati,et al.  Synthesis, docking study, and in vitro anticancer evaluation of new flufenamic acid derivatives , 2021 .

[10]  H. Alkahtani,et al.  New bis([1,2,4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, in silico studies, and anticancer evaluation. , 2021, Bioorganic chemistry.

[11]  M. Alanazi,et al.  Discovery of new VEGFR-2 inhibitors based on bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as anticancer agents and apoptosis inducers , 2021, Journal of enzyme inhibition and medicinal chemistry.

[12]  I. Eissa,et al.  Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR‐2 inhibitors , 2019, Archiv der Pharmazie.

[13]  M. Ohira,et al.  Sorafenib inhibits vascular endothelial cell proliferation stimulated by anaplastic thyroid cancer cells regardless of BRAF mutation status , 2019, International journal of oncology.

[14]  V. Kulkarni,et al.  Vascular Endothelial Growth Factor Receptor (VEGFR-2)/KDR Inhibitors: Medicinal Chemistry Perspective , 2019, Medicine in Drug Discovery.

[15]  M. Ohba,et al.  Receptor Tyrosine Kinase-Targeted Cancer Therapy , 2018, International journal of molecular sciences.

[16]  A. Jemal,et al.  Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries , 2018, CA: a cancer journal for clinicians.

[17]  Seong-ho Lee,et al.  Chemopreventive Properties of Tolfenamic Acid: A Mechanistic Review. , 2018, Current medicinal chemistry.

[18]  J. Duyster,et al.  Anti-Angiogenics: Current Situation and Future Perspectives , 2018, Oncology Research and Treatment.

[19]  Yonghe Li,et al.  Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens , 2017, Medicinal Chemistry Research.

[20]  R. Basha,et al.  Small molecule tolfenamic acid and dietary spice curcumin treatment enhances antiproliferative effect in pancreatic cancer cells via suppressing Sp1, disrupting NF-kB translocation to nucleus and cell cycle phase distribution. , 2016, The Journal of nutritional biochemistry.

[21]  A. Mansour,et al.  Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents , 2016, Scientific Reports.

[22]  R. Lencioni,et al.  Autocrine vascular endothelial growth factor signaling promotes cell proliferation and modulates sorafenib treatment efficacy in hepatocellular carcinoma , 2014, Hepatology.

[23]  S. Safe,et al.  Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors , 2014, Molecular carcinogenesis.

[24]  B. Han,et al.  The important roles of RET, VEGFR2 and the RAF/MEK/ERK pathway in cancer treatment with sorafenib , 2012, Acta Pharmacologica Sinica.

[25]  B. Sripanidkulchai,et al.  Evaluation of the anticancer potential of six herbs against a hepatoma cell line , 2012, Chinese Medicine.

[26]  Y. S. Shin,et al.  Tolfenamic Acid Induces Apoptosis and Growth Inhibition in Head and Neck Cancer: Involvement of NAG-1 Expression , 2012, PloS one.

[27]  Hua Wang,et al.  Role of death receptor, mitochondrial and endoplasmic reticulum pathways in different stages of degenerative human lumbar disc , 2011, Apoptosis.

[28]  R. Basha,et al.  Tolfenamic acid inhibits ovarian cancer cell growth and decreases the expression of c-Met and survivin through suppressing specificity protein transcription factors. , 2011, Gynecologic oncology.

[29]  S. Fulda,et al.  Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy , 2006, Oncogene.

[30]  K. Shikha,et al.  Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of some new 2-[(2,6-dichloroanilino) phenyl]acetic acid derivatives. , 2004, European journal of medicinal chemistry.

[31]  N. Ferrara Role of vascular endothelial growth factor in the regulation of angiogenesis. , 1999, Kidney international.

[32]  M. Shibuya,et al.  Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases. , 2013, Journal of biochemistry.