Khaya grandifoliola active fraction as a source of therapeutic compounds for Alzheimer’s disease treatment: In silico validation of identified compounds

[1]  R. Dubey,et al.  Computation screening of narcissoside a glycosyloxyflavone for potential novel coronavirus 2019 (COVID-19) inhibitor , 2020, Biomedical Journal.

[2]  P. Moundipa,et al.  Active chemical fractions of stem bark extract of Khaya grandifoliola C.DC and Entada africana Guill. et Perr. synergistically protect primary rat hepatocytes against paracetamol-induced damage , 2016, BMC Complementary and Alternative Medicine.

[3]  G. Tiegs,et al.  Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro , 2016, Archives of Virology.

[4]  R. Selvaraj,et al.  Molecular Docking Studies of Phytoconstituents Identified in Crocus sativus, Curcuma longa, Cassia occidentalis and Moringa oleifera on Thymidylate Synthase – An Enzyme Target for Anti-Cancer Activity - , 2016 .

[5]  R. Richardson,et al.  The role of nitric oxide in passive leg movement‐induced vasodilatation with age: insight from alterations in femoral perfusion pressure , 2015, The Journal of physiology.

[6]  Swetha Rudraiah,et al.  Antioxidant fractions of Khaya grandifoliola C.DC. and Entada africana Guill. et Perr. induce nuclear translocation of Nrf2 in HC-04 cells , 2015, Cell Stress and Chaperones.

[7]  F. Zipp,et al.  Molecular mechanisms linking neuroinflammation and neurodegeneration in MS , 2014, Experimental Neurology.

[8]  Yaoqi Tian,et al.  Polyphenols from blueberries modulate inflammation cytokines in LPS-induced RAW264.7 macrophages. , 2014, International journal of biological macromolecules.

[9]  Vasudeva Rao Avupati,et al.  In Silico Protein-Ligand Docking Studies on Thiazolidinediones as Potential Anticancer Agents , 2014 .

[10]  Liang-Jun Yan,et al.  Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease , 2014, The International journal of neuroscience.

[11]  R. Flavell,et al.  JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation , 2013, Science.

[12]  Ruth Nussinov,et al.  Structure and dynamics of molecular networks: A novel paradigm of drug discovery. A comprehensive review , 2012, Pharmacology & therapeutics.

[13]  S. Laufer,et al.  Development of a p38δ mitogen activated protein kinase ELISA assay for the quantitative determination of inhibitor activity. , 2012, Journal of pharmaceutical and biomedical analysis.

[14]  J. El Khoury,et al.  Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease , 2012, International journal of Alzheimer's disease.

[15]  David J Newman,et al.  Natural products as sources of new drugs over the 30 years from 1981 to 2010. , 2012, Journal of natural products.

[16]  Michael C. Ostrowski,et al.  NF-κB Signaling in Fetal Lung Macrophages Disrupts Airway Morphogenesis , 2011, The Journal of Immunology.

[17]  A. Bierhaus,et al.  Modulation of Macrophage Efferocytosis in Inflammation , 2011, Front. Immun..

[18]  J. Vederas,et al.  [Drug discovery and natural products: end of era or an endless frontier?]. , 2011, Biomeditsinskaia khimiia.

[19]  Haiwei Mou,et al.  Resveratrol differentially modulates inflammatory responses of microglia and astrocytes , 2010, Journal of Neuroinflammation.

[20]  Gisbert Schneider,et al.  Virtual screening: an endless staircase? , 2010, Nature Reviews Drug Discovery.

[21]  Kevin Struhl,et al.  An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation , 2009, Cell.

[22]  David R. Croucher,et al.  Activin A Is Essential for Neurogenesis Following Neurodegeneration , 2009, Stem cells.

[23]  A. Falodun,et al.  PHYTOCHEMICAL AND ANTI INFLAMMATORY EVALUATION OF KHAYA GRANDIFOLIOLA STEM BARK EXTRACT , 2009 .

[24]  F. Abiodun,et al.  Phytochemical Analysis and Antibacterial Activity of Khaya grandifoliola Stem Bark , 2009 .

[25]  T. Molinski,et al.  Drug development from marine natural products , 2009, Nature Reviews Drug Discovery.

[26]  U. Förstermann,et al.  Inducible Nitric Oxide Synthase , 2008 .

[27]  Sanjai Kumar,et al.  Assessment of safety of the major antimalarial drugs , 2007, Expert opinion on drug safety.

[28]  G. Petsko.  Transformation , 2006, Genome Biology.

[29]  V. Kolb-Bachofen,et al.  The role of nitric oxide. , 2006, Rheumatology.

[30]  P. Lirk,et al.  Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin. , 2005, Seminars in cancer biology.

[31]  Jiahuai Han,et al.  Activation and signaling of the p38 MAP kinase pathway , 2005, Cell Research.

[32]  Mark S Butler,et al.  The role of natural product chemistry in drug discovery. , 2004, Journal of natural products.

[33]  F. Aktan.  iNOS-mediated nitric oxide production and its regulation. , 2004, Life sciences.

[34]  C. Ferrari,et al.  Microglial activation with atypical proinflammatory cytokine expression in a rat model of Parkinson's disease , 2003, The European journal of neuroscience.

[35]  M. Panaro,et al.  Macrophage chemotactic protein-1 and macrophage inflammatory protein-1α induce nitric oxide release and enhance parasite killing in Leishmania infantum-infected human macrophages , 2002, Clinical and Experimental Medicine.

[36]  Y. Saeki,et al.  The role of TNF-alpha in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA/SCID mouse chimera. , 2002, Rheumatology.

[37]  J. Glass,et al.  Microglia in HIV‐associated neurological diseases , 2001, Microscopy research and technique.

[38]  D E Griswold,et al.  Inhibition of p38 MAP kinase as a therapeutic strategy. , 2000, Immunopharmacology.

[39]  H. Akiyama,et al.  Cell mediators of inflammation in the Alzheimer disease brain. , 2000, Alzheimer disease and associated disorders.

[40]  P. Ringwald,et al.  In vitro antimalarial activity of limonoids from Khaya grandifoliola C.D.C. (Meliaceae). , 2000, Journal of ethnopharmacology.

[41]  H. Aldskogius.  [Microglia--new target cells for neurological therapy]. , 2000, Läkartidningen.

[42]  G. Levi,et al.  Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide , 1998, Progress in Neurobiology.

[43]  Barry Halliwell,et al.  Evidence for nitric oxide‐mediated oxidative damage in chronic inflammation Nitrotyrosine in serum and synovial fluid from rheumatoid patients , 1994, FEBS letters.

[44]  W. Hopper.  Virtual Screening and Molecular Docking Studies of Compounds from Phaseolus Vulgaris against Nitric Oxide Synthase , 2022 .