Investigations of Sedative and Antidiarrheal Activity of Commelina appendiculata in Swiss Albino Mice

The aim of the present study was to investigate the sedative and antidiarrheal activity of ethanol extract of C. appendiculata at the doses of 100 and 200 mg/kg body weight per oral (p.o) in Swiss albino mice. Sedative activity of the extract (100 and 200 mg/kg, p.o.) was assessed utilizing thiopental sodium-induced sleeping time model to evaluate sedative potential of the extract, hole cross to evaluate motor activity and open field test to evaluate exploratory behaviour. The extract also produced rapid onset and maximized the duration of sleeping time when administered with thiopental sodium. The extract fundamentally (p < 0.05-0.001) diminished motor action and exploratory conduct of mice in hole cross and open field test separately. In antidiarreal activity study, the concentrate (200 mg/kg) likewise demonstrated most extreme inhibition of defecation (90.64% and 80.95%) in both models individually. The present study demonstrates that the ethanol extract of C. appendiculata have central nervous system (CNS) depressant and antidiarrheal properties. In this manner, the plant may be further investigated to find for its pharmacological active natural products.

[1]  M. Ali,et al.  Investigation of analgesic and cytotoxic activities of ethanol extract of Commelina appendiculata , 2015 .

[2]  M. Ali,et al.  Study of sedative activity of different extracts of Kaempferia galanga in Swiss albino mice , 2015, BMC Complementary and Alternative Medicine.

[3]  Guang-xiong Zhou,et al.  [Chemical constituents from Commelina communis]. , 2013, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[4]  T. Abere,et al.  Antidiarrhoea and toxicological evaluation of the leaf extract of Dissotis rotundifolia triana (Melastomataceae) , 2010, BMC complementary and alternative medicine.

[5]  O. T. Kolawole,et al.  Central nervous system depressant activity of Russelia equisetiformis. , 2010, Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.

[6]  G. Ye,et al.  A new C-glucoside from Commelina communis , 2009, Chemistry of Natural Compounds.

[7]  N. Matsugaki,et al.  Structure of commelinin, a blue complex pigment from the blue flowers of Commelina communis. , 2008, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

[8]  J. Ferreira,et al.  Antinociceptive activity of Mirabilis jalapa in mice. , 2008, Journal of ethnopharmacology.

[9]  G. Ye,et al.  Chemical Constituents of Commelina communis Linn. , 2007 .

[10]  A. Zezi,et al.  Evaluation of five medicinal plants used in diarrhoea treatment in Nigeria. , 2005, Journal of ethnopharmacology.

[11]  S. Sarker,et al.  Antidiarrhoeal activity of the methanol extract of the barks of Xylocarpus moluccensis in castor oil- and magnesium sulphate-induced diarrhoea models in mice. , 2005, Journal of ethnopharmacology.

[12]  F. G. Shoba,et al.  Study of antidiarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea. , 2001, Journal of ethnopharmacology.

[13]  R. Pérez,et al.  Neuropharmacological activity of Solanum nigrum fruit. , 1998, Journal of ethnopharmacology.

[14]  A. Murakami,et al.  Screening of edible Japanese plants for nitric oxide generation inhibitory activities in RAW 264.7 cells. , 1998, Cancer letters.

[15]  S. Bhattacharya,et al.  Experimental methods for evaluation of psychotropic agents in rodents: I--Anti-anxiety agents. , 1997, Indian journal of experimental biology.

[16]  K. Saha,et al.  ANTI-DIARRHOEL EVALUATION OF NELUMBO NUCIFERA RHIZOME EXTRACT , 1995 .

[17]  Z. H. Zhang,et al.  [Active constituents of Commelina communis L]. , 1994, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[18]  A. Izzo,et al.  Inhibitors of nitric oxide synthetase prevent castor‐oil‐induced diarrhoea in the rat , 1993, British journal of pharmacology.

[19]  A. Nakagawa,et al.  Structural basis of blue-colour development in flower petals from Commelina communis , 1992, Nature.

[20]  P. D. de Witte,et al.  Antidiarrhoeic activity of Sclerocarya birrea bark extract and its active tannin constituent in rats , 1991 .

[21]  G. S. Morato,et al.  Pharmacological Actions of Tannic Acid; II. Evaluation of CNS Activity in Animals , 1986, Planta medica.

[22]  N. Doherty,et al.  INHIBITION OF ARACHIDONIC ACID RELEASE AS THE MECHANISM BY WHICH GLUCOCORTICOIDS INHIBIT ENDOTOXIN‐INDUCED DIARRHOEA , 1981, British journal of pharmacology.

[23]  J. Harborne,et al.  Two distinctive anthocyanin patterns in the commelinaceae , 1980 .

[24]  H. Juan,et al.  Effect of ricinoleic acid and other laxatives on net water flux and prostaglandin E release by the rat colon † , 1979, The Journal of pharmacy and pharmacology.

[25]  T. Gaginella,et al.  Ricinoleic acid: Current view of an ancient oil , 1975, The American Journal of Digestive Diseases.

[26]  C. N. Gillis,et al.  Screening Methods in Pharmacology , 1965, The Yale Journal of Biology and Medicine.

[27]  Samir Banerjee,et al.  Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds. , 2010, Fitoterapia.

[28]  A. Mishra,et al.  Pharmacological Evaluation of Saraca indica Leaves for Central Nervous System Depressant Activity in Mice , 2010 .

[29]  Z. Begum,et al.  Encyclopedia of flora and fauna of Bangladesh , 2007 .

[30]  M. Lu.  Studies on the sedative effect of Cistanche deserticola. , 1998, Journal of ethnopharmacology.

[31]  H. Tamura,et al.  Structure of malonylawobanin, the real anthocyanin present in blue-colored flower petals of Commelina communis , 1983 .

[32]  S. Sharma,et al.  A dammarane triterpene from Commelina undulata , 1982 .

[33]  H. Saito,et al.  Studies of the spontaneous movement of animals by the hole cross test; effect of 2-dimethyl-aminoethanol and its acyl esters on the central nervous system. , 1971, Japanese journal of pharmacology.

[34]  M. Gupta,et al.  A psycho-pharmacological analysis of behaviour in rats. , 1971, Japanese journal of pharmacology.

[35]  R. Turner.  CHAPTER 6 – DEPRESSANTS OF THE CENTRAL NERVOUS SYSTEM , 1965 .