Nondipolar Content of T Wave Derived from a Myocardial Source Simulation with Increased Repolarization Inhomogeneity

Background: Several conditions with repolarization disturbances are associated with increased level of nondipolar components of the T wave. The nondipolar content has been proposed as a measure of repolarization inhomogeneity. This computer simulation study examines the link between increased nondipolar components and increased repolarization inhomogeneity in an established model.

[1]  Joel Xue,et al.  Are nondipolar components of electrocardiogram correlated to repolarization abnormality in ischemic patients or to noise , 2005 .

[2]  P. Rautaharju.  A farewell to QT dispersion. Are the alternatives any better? , 2005, Journal of electrocardiology.

[3]  Rémi Dubois,et al.  T‐Wave Morphology Parameters Based on Principal Component Analysis Reproducibility and Dependence on T−Offset Position , 2007, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

[4]  A. Jaffe,et al.  Cardiac magnetic resonance imaging study for quantification of infarct size comparing directly serial versus single time-point measurements of cardiac troponin T. , 2008, Journal of the American College of Cardiology.

[5]  B. Surawicz,et al.  Characteristics and Possible Mechanism of Ventricular Arrhythmia Dependent on the Dispersion of Action Potential Durations , 1983, Circulation.

[6]  Joel Xue,et al.  Principal Component Analysis of the T Wave in Patients with Chest Pain and Conduction Disturbances , 2004, Pacing and clinical electrophysiology : PACE.

[7]  T. Musha,et al.  Dipolarity and dipole location during QRS and T waves in normal men estimated from body surface potential distribution. , 1985, Japanese heart journal.

[8]  Alan H Feiveson,et al.  The effect of signal averaging on the reproducibility and reliability of measures of T-wave morphology. , 2006, Journal of electrocardiology.

[9]  H. Helmholtz.  Ueber einige Gesetze der Vertheilung elektrischer Ströme in körperlichen Leitern mit Anwendung auf die thierisch‐elektrischen Versuche , 1853 .

[10]  Arthur J Moss.  What Resides in T‐wave Residuum? , 2005, Journal of cardiovascular electrophysiology.

[11]  Jeroen J. Bax,et al.  Dispersion of repolarization in cardiac resynchronization therapy. , 2005, Heart rhythm.

[12]  B. Lindahl,et al.  Non‐dipolar content of the T‐wave as a measure of repolarization inhomogeneity in ST‐elevation myocardial infarction , 2006, Clinical physiology and functional imaging.

[13]  A J Camm,et al.  QT Dispersion Does Not Represent Electrocardiographic Interlead Heterogeneity of Ventricular Repolarization , 2000, Journal of cardiovascular electrophysiology.

[14]  Katerina Hnatkova,et al.  Analysis of T-Wave Morphology From the 12-Lead Electrocardiogram for Prediction of Long-Term Prognosis in Male US Veterans , 2002, Circulation.

[15]  P. Arini,et al.  Role of Dipolar and Nondipolar Components of the T Wave in Determining the T Wave Residuum in an Isolated Rabbit Heart Model , 2004, Journal of cardiovascular electrophysiology.

[16]  P. Schwartz,et al.  Mapping of body surface potentials in patients with the idiopathic long QT syndrome. , 1986, Circulation.

[17]  A. van Oosterom,et al.  ECGSIM: an interactive tool for studying the genesis of QRST waveforms , 2004, Heart.

[18]  M. Schalij,et al.  Validation of ECG Indices of Ventricular Repolarization Heterogeneity: A Computer Simulation Study , 2005, Journal of cardiovascular electrophysiology.