Regulation of cellular differentiation during Dictyostelium morphogenesis.

In Dictyostelium there are multiple prestalk cell types that have a complex pattern of directed cell movement during slug formation and culmination. Three extracellular signals, cyclic AMP, DIF and ammonia, control cell type differentiation. Recently there has been considerable progress in understanding their modes of action and interaction.

[1]  J. Williams,et al.  An analysis of culmination in Dictyostelium using prestalk and stalk-specific cell autonomous markers. , 1991, Development.

[2]  R. Kay,et al.  Combinatorial control of cell differentiation by cAMP and DIF-1 during development of Dictyostelium discoideum. , 1990, Development.

[3]  D. L. Richardson,et al.  A prespore gene, Dd31, expressed during culmination of Dictyostelium discoideum. , 1991, Developmental biology.

[4]  R. Firtel,et al.  cAMP and cell sorting control the spatial expression of a developmentally essential cell-type-specific ras gene in Dictyostelium. , 1991, Genes & development.

[5]  M. Sussman,et al.  Ammonia determines the choice of morphogenetic pathways in Dictyostelium discoideum. , 1977, Journal of molecular biology.

[6]  J. Bonner,et al.  Timing of the formation of the prestalk and prespore zones in Dictyostelium discoideum , 1990 .

[7]  T. Kakutani,et al.  Characterization of anterior-like cells in Dictyostelium as analyzed by their movement , 1986 .

[8]  C N David,et al.  Fate and regulation of anterior-like cells in Dictyostelium slugs. , 1982, Developmental biology.

[9]  R. Firtel,et al.  G protein linked signal transduction pathways in development: Dictyostelium as an experimental system , 1989, Cell.

[10]  J. Williams,et al.  Cytoplasmic acidification facilitates but does not mediate DIF-induced prestalk gene expression in Dictyostelium discoideum. , 1990, Developmental biology.

[11]  Jeffrey G. Williams,et al.  Positively and negatively acting signals regulating stalk cell and anterior-like cell differentiation in dictyostelium , 1991, Cell.

[12]  David P. Lane,et al.  Origins of the prestalk-prespore pattern in Dictyostelium development , 1989, Cell.

[13]  J. Bonner,et al.  Regulation of the anterior-like cell state by ammonia in Dictyostelium discoideum. , 1990, Developmental genetics.

[14]  R. Kay,et al.  Intracellular pH and the control of cell differentiation in Dictyostelium discoideum , 1983, Nature.

[15]  J. Gibbs Ras C-terminal processing enzymes—New drug targets? , 1991, Cell.

[16]  G. Weeks,et al.  A possible role for DIF-2 in the formation of stalk cells during Dictyostelium development. , 1991, Developmental biology.

[17]  J. Bonner,et al.  The Role of Surface Water and Light on Differentiation in the Cellular Slime Molds , 1982 .

[18]  J. Williams,et al.  A new anatomy of the prestalk zone in Dictyostelium , 1989, Nature.

[19]  S. Robbins,et al.  A Dictyostelium morphogen that is essential for stalk cell formation is generated by a subpopulation of prestalk cells. , 1990, Development.

[20]  R. Kay,et al.  A specific DIF binding protein in Dictyostelium. , 1990, The EMBO journal.

[21]  R. Kay,et al.  The DIF-1 signaling system in Dictyostelium. Metabolism of the signal. , 1991, Journal of Biological Chemistry.

[22]  J. Williams,et al.  Unexpected localisation of cells expressing a prespore marker of Dictyostelium discoideum. , 1991, Differentiation; research in biological diversity.

[23]  J. Tyson,et al.  Cyclic AMP waves during aggregation of Dictyostelium amoebae. , 1989, Development.

[24]  R. Kay,et al.  Structure elucidation of two differentiation inducing factors (DIF-2 and DIF-3) from the cellular slime mould Dictyostelium discoideum. , 1988, The Biochemical journal.

[25]  H. M. Williams,et al.  Cell sorting within the prestalk zone of Dictyostelium discoideum. , 1991 .

[26]  R. Kay Evidence that elevated intracellular cyclic AMP maturation in Dictyostelium , 1989 .

[27]  R. Firtel,et al.  A spatial gradient of expression of a cAMP-regulated prespore cell-type-specific gene in Dictyostelium. , 1990, Genes & development.

[28]  F. Siegert,et al.  Analysis of optical density wave propagation and cell movement in the cellular slime mould Dictyostelium discoideum , 1991 .

[29]  C. N. David,et al.  Cell Sorting daring Pattern Formation in Dictyostelium , 1981 .