Allergy blood testing: A practical guide for clinicians

Blood tests are available that measure levels of immunoglobulin E (IgE) against specific allergens such as foods, inhalants, medications, latex, and venoms. These tests can confirm the diagnosis of an allergic disorder, supplementing a clinical history consistent with an immediate allergic reaction. They are particularly useful when skin testing cannot or should not be performed. These tests can confirm the diagnosis of an allergic disorder, supplementing the clinical history. They are particularly useful when skin testing cannot or should not be done.

[1]  G. Wegienka,et al.  Analysis of allergen specific IgE cut points to cat and dog in the Childhood Allergy Study. , 2011, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[2]  S. Spector,et al.  Allergen immunotherapy: a practice parameter third update. , 2007, The Journal of allergy and clinical immunology.

[3]  Carol Byrd-Bredbenner,et al.  Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report. , 2011, Nutrition research.

[4]  S. Spector,et al.  The diagnosis and management of anaphylaxis practice parameter: 2010 update. , 2010, The Journal of allergy and clinical immunology.

[5]  E. Macy,et al.  Use of commercial anti-penicillin IgE fluorometric enzyme immunoassays to diagnose penicillin allergy. , 2010, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[6]  P. Williams,et al.  Human IgE antibody serology: a primer for the practicing North American allergist/immunologist. , 2010, The Journal of allergy and clinical immunology.

[7]  R. Hamilton Clinical laboratory assessment of immediate-type hypersensitivity. , 2010, The Journal of allergy and clinical immunology.

[8]  Carol Byrd-Bredbenner,et al.  Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report. , 2010, The Journal of allergy and clinical immunology.

[9]  P. Gamboa,et al.  In vitro diagnosis of immediate allergic reactions to drugs: an update. , 2010, Journal of investigational allergology & clinical immunology.

[10]  L. Cox,et al.  Pearls and pitfalls of allergy diagnostic testing: report from the American College of Allergy, Asthma and Immunology/American Academy of Allergy, Asthma and Immunology Specific IgE Test Task Force. , 2008, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[11]  S. Spector,et al.  The diagnosis and management of rhinitis: an updated practice parameter. , 2008, The Journal of allergy and clinical immunology.

[12]  Linda Cox,et al.  Allergy diagnostic testing: an updated practice parameter. , 2008, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[13]  T. Brüning,et al.  Quantitative analysis of immunoglobulin E reactivity profiles in patients allergic or sensitized to natural rubber latex (Hevea brasiliensis) , 2007, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[14]  L. Venemalm,et al.  Immunoglobulin E Antibodies to Rocuronium: A New Diagnostic Tool , 2007, Anesthesiology.

[15]  D. Ebo,et al.  IgE‐mediated anaphylaxis from chlorhexidine: diagnostic possibilities , 2006, Contact dermatitis.

[16]  E. Krieg,et al.  Latex specific IgE: performance characteristics of the IMMULITE 2000 3gAllergy assay compared with skin testing. , 2006, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[17]  H. Mosbech,et al.  Diagnosis of Hymenoptera venom allergy , 2005, Allergy.

[18]  Robert G Hamilton,et al.  In vitro assays for the diagnosis of IgE-mediated disorders. , 2004, The Journal of allergy and clinical immunology.

[19]  W. Pichler Immune mechanism of drug hypersensitivity. , 2004, Immunology and allergy clinics of North America.

[20]  Hugh A Sampson,et al.  Update on food allergy. , 2004, The Journal of allergy and clinical immunology.

[21]  S. Spector,et al.  Stinging insect hypersensitivity: a practice parameter update. , 2004, The Journal of allergy and clinical immunology.

[22]  L. Söderström,et al.  A further evaluation of the clinical use of specific IgE antibody testing in allergic diseases , 2003, Allergy.

[23]  J. Barnes,et al.  Are our impressions of allergy test performances correct? , 2003, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[24]  V. Backer,et al.  In vitro diagnostic evaluation of patients with inhalant allergies: summary of probability outcomes comparing results of CLA- and CAP-specific immunoglobulin E test systems. , 2003, Allergy and asthma proceedings.

[25]  E. Peterson,et al.  Clinical and laboratory-based methods in the diagnosis of natural rubber latex allergy. , 2002, The Journal of allergy and clinical immunology.

[26]  A. Romano,et al.  Clinical evaluation of Pharmacia CAP System™ RAST FEIA amoxicilloyl and benzylpenicilloyl in patients with penicillin allergy , 2001, Allergy.

[27]  D. Golden,et al.  Insect sting allergy with negative venom skin test responses. , 2001, The Journal of allergy and clinical immunology.

[28]  J. Portnoy,et al.  Efficacy of a single diagnostic test for sensitization to common inhalant allergens. , 2001, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[29]  G. Clough,et al.  Inhibition by glucocorticoids of the mast cell‐dependent weal and flare response in human skin in vivo , 2001, British journal of pharmacology.

[30]  C. Goodman,et al.  In vitro and skin testing for allergy: comparable clinical utility and costs. , 1998, The American journal of managed care.

[31]  A. Romano,et al.  Determination of IgE antibodies to the benzylpenicilloyl determinant: A comparison of the sensitivity and specificity of three radio allergo sorbent test methods , 1997, Journal of clinical laboratory analysis.

[32]  J. Bousquet,et al.  Long-term oral corticosteroid therapy does not alter the results of immediate-type allergy skin prick tests. , 1996, The Journal of allergy and clinical immunology.

[33]  J. S. Taylor,et al.  Latex hypersensitivity in emergency medical service providers. , 1996, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[34]  M. Sakaguchi,et al.  IgE antibody to gelatin in children with immediate-type reactions to measles and mumps vaccines. , 1995, The Journal of allergy and clinical immunology.

[35]  H. Sampson,et al.  Skin testing with natural foods in patients suspected of having food allergies: is it a necessity? , 1994, The Journal of allergy and clinical immunology.

[36]  W. Dolen,et al.  Comparison of skin testing and three in vitro assays for specific IgE in the clinical evaluation of immediate hypersensitivity. , 1992, Annals of allergy.

[37]  P Bachner,et al.  Laboratory phlebotomy. College of American Pathologists Q-Probe study of patient satisfaction and complications in 23,783 patients. , 1991, Archives of pathology & laboratory medicine.

[38]  J. Saint-Remy,et al.  Seasonal variation in specific IgE antibodies of grass-pollen hypersensitive patients depends on the steady state IgE concentration and is not related to clinical symptoms. , 1989, The Journal of allergy and clinical immunology.

[39]  U. Pipkorn,et al.  Prolonged treatment with topical glucocorticoids results in an inhibition of the allergen‐induced weal‐and‐flare response and a reduction in skin mast cell numbers and histamine content , 1989, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[40]  P. Turkeltaub,et al.  The risk of adverse reactions from percutaneous prick-puncture allergen skin testing, venipuncture, and body measurements: data from the second National Health and Nutrition Examination Survey 1976-80 (NHANES II). , 1989, The Journal of allergy and clinical immunology.

[41]  J. Bousquet,et al.  Nasal challenge with pollen grains, skin‐prick tests and specific IgE in patients with grass pollen allergy , 1987, Clinical allergy.

[42]  A. Lauritano,et al.  Evaluation of Patients With Local Reactions to Insulin With Skin Tests and In Vitro Techniques , 1987, Diabetes Care.