Histatin 1 enhanced the speed and quality of wound healing through regulating the behaviour of fibroblast

Histatin 1(Hst 1) has been proved to promote wound healing. However, there was no specific study on the regulation made by Hst 1 of fibroblasts in the process of wound healing. This research comprehensively studied the regulation of Hst 1 on the function of fibroblasts in the process of wound healing and preliminary mechanism about it.

[1]  Qiong Gao,et al.  Effects and mechanisms of histatins as novel skin wound-healing agents. , 2021, Journal of tissue viability.

[2]  Xiaobing Fu.  Wound healing center establishment and new technology application in improving the wound healing quality in China , 2020, Burns & trauma.

[3]  Futing Shu,et al.  Exosomes derived from human amniotic epithelial cells accelerate diabetic wound healing via PI3K-AKT-mTOR-mediated promotion in angiogenesis and fibroblast function , 2020, Burns & trauma.

[4]  F. Bikker,et al.  Human Salivary Histatin-1 Is More Efficacious in Promoting Acute Skin Wound Healing Than Acellular Dermal Matrix Paste , 2020, Frontiers in Bioengineering and Biotechnology.

[5]  L. Bian,et al.  Injectable supramolecular gelatin hydrogel loading of resveratrol and histatin-1 for burn wound therapy. , 2020, Biomaterials science.

[6]  Weifeng He,et al.  Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization , 2020, Burns & trauma.

[7]  Y. Guan,et al.  Smooth muscle-specific TMEM16A expression protects against angiotensin II-induced cerebrovascular remodeling via suppressing extracellular matrix deposition. , 2019, Journal of molecular and cellular cardiology.

[8]  G. Gurtner,et al.  Age‐associated intracellular superoxide dismutase deficiency potentiates dermal fibroblast dysfunction during wound healing , 2019, Experimental dermatology.

[9]  G. Gurtner,et al.  Wound Healing: A Cellular Perspective. , 2019, Physiological reviews.

[10]  V. Torres,et al.  Histatins, wound healing, and cell migration. , 2018, Oral diseases.

[11]  P. Asbell,et al.  In Vivo Efficacy of Histatin-1 in a Rabbit Animal Model , 2018, Current eye research.

[12]  V. Palma,et al.  The salivary peptide histatin‐1 promotes endothelial cell adhesion, migration, and angiogenesis , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[13]  R. Hoebe,et al.  Human salivary peptide histatin‐1 stimulates epithelial and endothelial cell adhesion and barrier function , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[14]  Ye-yang Li,et al.  ILK–PI3K/AKT pathway participates in cutaneous wound contraction by regulating fibroblast migration and differentiation to myofibroblast , 2016, Laboratory Investigation.

[15]  K. Leung,et al.  LXA4 actions direct fibroblast function and wound closure. , 2015, Biochemical and biophysical research communications.

[16]  S. Rennard,et al.  Matrix metalloproteinase-9 activates TGF-β and stimulates fibroblast contraction of collagen gels. , 2014, American journal of physiology. Lung cellular and molecular physiology.

[17]  Fiona M. Watt,et al.  Distinct fibroblast lineages determine dermal architecture in skin development and repair , 2013, Nature.

[18]  Ramana M Pidaparti,et al.  A biomechanical model of wound contraction and scar formation. , 2013, Journal of theoretical biology.

[19]  David T Corr,et al.  Biomechanics of Scar Tissue and Uninjured Skin. , 2013, Advances in wound care.

[20]  D. Sabatini,et al.  mTOR Signaling in Growth Control and Disease , 2012, Cell.

[21]  B. Hinz,et al.  Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. , 2012, The American journal of pathology.

[22]  F. Al-Mulla,et al.  Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes. , 2011, Molecular bioSystems.

[23]  B. Hinz,et al.  Hypoxia impairs skin myofibroblast differentiation and function. , 2010, The Journal of investigative dermatology.

[24]  Lei Zhang,et al.  Vascular endothelial growth factor promotes cardiac stem cell migration via the PI3K/Akt pathway. , 2009, Experimental cell research.

[25]  A. Ridley,et al.  Phosphoinositide 3‐kinases in cell migration , 2009, Biology of the cell.

[26]  E. Veerman,et al.  Histatins are the major wound‐closure stimulating factors in human saliva as identified in a cell culture assay , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[27]  G. Gabbiani,et al.  Persistent Ischemia Impairs Myofibroblast Development in Wound Granulation Tissue: a New Model of Delayed Wound Healing Wound Repair and Regeneration , 2022 .

[28]  D. Greenhalgh,et al.  Cutaneous Wound Healing , 2007, Journal of burn care & research : official publication of the American Burn Association.

[29]  B. Hinz.  Formation and function of the myofibroblast during tissue repair. , 2007, The Journal of investigative dermatology.

[30]  J. Qin,et al.  SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity , 2006, Cell.

[31]  S. O'Kane,et al.  Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. , 2004, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[32]  Jacques Neefjes,et al.  A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation. , 2004, Immunity.

[33]  S. Werner,et al.  Wound repair and regeneration , 1994, Nature.

[34]  B. Edgar,et al.  Rheb promotes cell growth as a component of the insulin/TOR signalling network , 2003, Nature Cell Biology.

[35]  B. Hinz,et al.  Myofibroblasts and mechano-regulation of connective tissue remodelling , 2002, Nature Reviews Molecular Cell Biology.

[36]  B. Hinz,et al.  Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. , 2001, Molecular biology of the cell.

[37]  S. Phan,et al.  Regulation of alpha-smooth muscle actin gene expression in myofibroblast differentiation from rat lung fibroblasts. , 2001, The international journal of biochemistry & cell biology.

[38]  Bharat Jasani,et al.  Human Wound Contraction: Collagen Organization, Fibroblasts, and Myofibroblasts , 1998, Plastic and reconstructive surgery.

[39]  E. Veerman,et al.  Synthetic histatin analogues with broad-spectrum antimicrobial activity. , 1997, The Biochemical journal.

[40]  G. Gabbiani,et al.  Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. , 1990, Laboratory investigation; a journal of technical methods and pathology.

[41]  T. Hoffmann,et al.  Peptide therapeutics: current status and future directions. , 2015, Drug discovery today.