Prevalence of epilepsy in the People's Republic of China: A systematic review

To date there has not been a nationwide systematic analysis of the prevalence of epilepsy in China. The aim of this study was to estimate the prevalence of epilepsy in mainland China from the published studies and analyze the prevalence of epilepsy by survey method, gender, location, age, seizure type and prevalence of date. We searched the PubMed, Embase, Chinese Biological Medical Literature (CBM), Chinese National Knowledge Infrastructure (CNKI), Chinese Wanfang and Chongqing VIP databases for epidemiological studies on the prevalence of epilepsy. Thirty-eight studies were included that comprised a total sample size of 7,695,961, among whom 13,224 had epilepsy. The overall prevalence of epilepsy was 2.89‰. The prevalence of males and females were 3.83‰ and 3.45‰, respectively. The location-specific prevalence in urban and rural areas was 2.34‰ and 3.17‰, respectively. Prevalence by age groups, 0-9, 10-19, 20-29, 30-39, 40-49, 50-59, 60-69 and ≥70 were 2.21‰, 3.23‰, 3.14‰, 2.83‰, 2.96‰, 2.61‰, 2.76‰ and 2.22‰, respectively. In the subgroup analysis by prevalence date, prevalence rate of epilepsy ranged from 1.19‰ to 6.70‰. As for the seizure types, the overall prevalence of generalized seizures, partial seizures and unclassifiable seizures were 3.12‰, 0.57‰ and 0.23‰, respectively. Overall, the prevalence rate of epilepsy is different for each area in mainland China. A higher prevalence of epilepsy is found in the subgroup analysis by male, rural, age group of 10-19 and generalized seizures. However, more epidemiological studies are needed from other provinces to estimate the overall prevalence of epilepsy in mainland China.

[1]  M. Rinaldis,et al.  High prevalence of epilepsy in a village in the Littoral Province of Cameroon , 2008, Epilepsy Research.

[2]  J. Muliyil,et al.  Active epilepsy as an index of burden of neurocysticercosis in Vellore district, India , 2006, Neurology.

[3]  B. Xiao,et al.  Investigation of prevalence, clinical characteristics and management of epilepsy in Yueyang city of China by a door-to-door survey , 2012, Epilepsy Research.

[4]  W. Hauser,et al.  Prevalence of Epilepsy in Rural Iceland: A Population‐Based Study , 1999, Epilepsia.

[5]  E. Beghi,et al.  The epidemiology of epilepsy in Europe – a systematic review , 2005, European journal of neurology.

[6]  E. Faught.  Epidemiology and Drug Treatment of Epilepsy in Elderly People , 1999, Drugs & aging.

[7]  S. Wiebe,et al.  Understanding the burden of epilepsy in Latin America: A systematic review of its prevalence and incidence , 2005, Epilepsy Research.

[8]  P. Hunter,et al.  Treatment of cryptosporidiosis in immunocompromised individuals: systematic review and meta-analysis. , 2007, British journal of clinical pharmacology.

[9]  M. Leonardi,et al.  The Global Burden of Epilepsy , 2002, Epilepsia.

[10]  V N Halatchev,et al.  Epidemiology of epilepsy--recent achievements and future. , 2000, Folia medica.

[11]  U Kramer,et al.  Epidemiology of epilepsy in childhood: a cohort of 440 consecutive patients. , 1998, Pediatric neurology.

[12]  Sangwan,et al.  Prevalence of convulsive epilepsy and health-related quality of life of the population with convulsive epilepsy in rural areas of Tibet Autonomous Region in China: An initial survey , 2008, Epilepsy & Behavior.

[13]  Samuel Wiebe,et al.  Epilepsy in North America: A Report Prepared under the Auspices of the Global Campaign against Epilepsy, the International Bureau for Epilepsy, the International League Against Epilepsy, and the World Health Organization , 2006, Epilepsia.

[14]  M. Coory,et al.  Comment on: Heterogeneity in meta-analysis should be expected and appropriately quantified. , 2010, International journal of epidemiology.

[15]  P. Cooper,et al.  The prevalence of epilepsy in the Zay Society, Ethiopia—An area of high prevalence , 2006, Seizure.

[16]  H. Benamer,et al.  A systematic review of the epidemiology of epilepsy in Arab countries , 2009, Epilepsia.

[17]  Chuanzhen Lu,et al.  [The prevalence of epilepsy in rural Jinshan in Shanghai]. , 2002, Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi.

[18]  A. Kleinman,et al.  The social course of epilepsy: chronic illness as social experience in interior China. , 1995, Social science & medicine.

[19]  B. Schoenberg,et al.  Epidemiology of Epilepsy in Urban Areas of the People's Republic of China , 1985, Epilepsia.

[20]  Julian P T Higgins,et al.  Commentary: Heterogeneity in meta-analysis should be expected and appropriately quantified. , 2008, International journal of epidemiology.

[21]  Christian Bottomley,et al.  Estimation of the burden of active and life-time epilepsy: A meta-analytic approach , 2010, Epilepsia.

[22]  P. Lavados,et al.  A descriptive study of epilepsy in the district of El Salvador, Chile, 1984–1988 , 1992, Acta neurologica Scandinavica.

[23]  P Jallon,et al.  Epilepsy in Developing Countries , 1997, Epilepsia.

[24]  M. Druet‐Cabanac,et al.  Prevalence of Epilepsy in a Rural District of Central Lao PDR , 2006, Neuroepidemiology.

[25]  E. Reynolds,et al.  The ILAE/IBE/WHO Global Campaign against Epilepsy: Bringing Epilepsy “Out of the Shadows” , 2000, Epilepsy & Behavior.

[26]  M. Druet‐Cabanac,et al.  Epidemiology and aetiology of epilepsy in sub-Saharan Africa , 2005, The Lancet Neurology.

[27]  Graham Mitchell,et al.  Out of the Shadows , 1999 .

[28]  Wenzhi Wang,et al.  [Epidemiological survey on epilepsy among rural populations in five provinces in China]. , 2002, Zhonghua yi xue za zhi.

[29]  Josemir W. Sander,et al.  Epidemiology of the epilepsies. , 1996, Handbook of clinical neurology.

[30]  W. Hauser,et al.  Descriptive epidemiology of epilepsy: contributions of population-based studies from Rochester, Minnesota. , 1996, Mayo Clinic proceedings.

[31]  S. Kochen,et al.  Prevalence and Clinical Features of Epilepsy in Argentina , 2006, Neuroepidemiology.

[32]  Josemir W Sander,et al.  CPD — Education and self-assessment The epidemiology of epilepsy: the size of the problem , 2001, Seizure.

[33]  M. Druet‐Cabanac,et al.  Estimation of the prevalence of epilepsy in the Benin region of Zinvié using the capture-recapture method. , 2000, International journal of epidemiology.

[34]  J. Knottnerus,et al.  Systematic Review and Meta‐analysis of Incidence Studies of Epilepsy and Unprovoked Seizures , 2002, Epilepsia.

[35]  J. Eslava-Cobos,et al.  Epilepsy in Colombia: Epidemiologic Profile and Classification of Epileptic Seizures and Syndromes , 2006, Epilepsia.

[36]  H. Meinardi,et al.  Epilepsy in the Tropics: I. Epidemiology, Socioeconomic Risk Factors, and Etiology , 1996, Epilepsia.

[37]  H. Aziz,et al.  Comparative Epidemiology of Epilepsy in Pakistan and Turkey: Population‐Based Studies Using Identical Protocols , 1997, Epilepsia.

[38]  W. Rocca,et al.  Door-to-Door Prevalence Survey of Epilepsy in Three Sicilian Municipalities , 2001, Neuroepidemiology.

[39]  Josemir W Sander,et al.  Global campaign against epilepsy : assessment of a demonstration project in rural China , 2008 .

[40]  Jeong-Min Hwang,et al.  Clinical and Oculographic Findings of X-linked Congenital Nystagmus in Three Korean Families , 2007, Journal of clinical neurology.