Nanotechnology and its Applications in Medicine

Nanotechnologyis the study of extremely small structures, having size of 0.1 to 100 nm. Nano medicine is a relatively new field of science and technology. Brief explanation of various types of pharmaceutical nano systems is given. Classification of nano materials based on their dimensions is given. An application of Nanotechnology in various fields such as health and medicine, electronics, energy and environment, is discussed in detail. Applications of nano particles in drug delivery, protein and peptide delivery, cancer are explained. Applications of various nano systems in cancer therapy such as carbon nano tube, dendrimers, nano crystal, nano wire, nano shells etc. are given. The advancement in nano technology helps in the treatment of neuro degenerative disorders such as Parkinson’s disease and Alzheimer’s disease. Applications of nano technology in tuberculosis treatment, the clinical application of nanotechnology in operative dentistry, in ophthalmology, in surgery, visualization, tissue engineering, antibiotic resistance, immune response are discussed in this article. Nano pharmaceuticals can be used to detect diseases at much earlier stages.

[1]  R. Freitas Nanotechnology, nanomedicine and nanosurgery. , 2005, International journal of surgery.

[2]  Efstathios Karathanasis,et al.  Enhanced delivery of chemotherapy to tumors using a multicomponent nanochain with radio-frequency-tunable drug release. , 2012, ACS nano.

[3]  Y. Khan The Great Partition: The Making of India and Pakistan , 2007 .

[4]  G. Marosi,et al.  Comparison of electrospun and extruded Soluplus®-based solid dosage forms of improved dissolution. , 2012, Journal of pharmaceutical sciences.

[5]  T. Lu,et al.  Surface charge-switching polymeric nanoparticles for bacterial cell wall-targeted delivery of antibiotics. , 2012, ACS nano.

[6]  P. Cullis,et al.  Drug Delivery Systems: Entering the Mainstream , 2004, Science.

[7]  Patrick Boisseau,et al.  Nanomedicine, Nanotechnology in medicine , 2011 .

[8]  Zheng Wang,et al.  Advances and Prospect of Nanotechnology in Stem Cells , 2009, Nanoscale research letters.

[9]  G. Wei,et al.  A novel nanoscale-dispersed eye ointment for the treatment of dry eye disease , 2014, Nanotechnology.

[10]  Rebekah A Drezek,et al.  Near infrared laser‐tissue welding using nanoshells as an exogenous absorber , 2005, Lasers in surgery and medicine.

[11]  Ali Moballegh,et al.  ZnO nanoparticles enhanced antibacterial activity of ciprofloxacin against Staphylococcus aureus and Escherichia coli. , 2010, Journal of biomedical materials research. Part B, Applied biomaterials.

[12]  S. Krishnakumar,et al.  Nanotechnology in ocular drug delivery. , 2008, Drug discovery today.

[13]  X. Wu,et al.  Nanotechnological advances for the delivery of CNS therapeutics. , 2012, Advanced drug delivery reviews.

[14]  Peixuan Guo,et al.  Ultrastable synergistic tetravalent RNA nanoparticles for targeting to cancers. , 2012, Nano today.

[15]  Tad Hogg,et al.  Nanorobot architecture for medical target identification , 2008 .

[16]  Aaron J. Martin,et al.  Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis , 2012, Nature Biotechnology.

[17]  Robert Langer,et al.  Small-scale systems for in vivo drug delivery , 2003, Nature Biotechnology.

[18]  Gengfeng Zheng,et al.  Multiplexed electrical detection of cancer markers with nanowire sensor arrays , 2005, Nature Biotechnology.

[19]  M. Griffith,et al.  Nanotechnology in stem cells research: advances and applications. , 2012, Frontiers in bioscience.

[20]  Nicolas Bertrand,et al.  The journey of a drug-carrier in the body: an anatomo-physiological perspective. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[21]  Leon Hirsch,et al.  Nanoshell-Enabled Photonics-Based Imaging and Therapy of Cancer , 2004, Technology in cancer research & treatment.

[22]  Patrick Couvreur,et al.  Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues. , 2011, Nanomedicine : nanotechnology, biology, and medicine.

[23]  Shuming Nie,et al.  Nanotechnology for targeted cancer therapy , 2007, Expert review of anticancer therapy.

[24]  P. Neelakantan,et al.  Nanotechnology In Dentistry - What Does The Future Hold In Store? , 2014 .

[25]  R. Ritch,et al.  Nanomedicine for the treatment of retinal and optic nerve diseases. , 2013, Current opinion in pharmacology.

[26]  S. Nie,et al.  Nanotechnology applications in cancer. , 2007, Annual review of biomedical engineering.

[27]  Moustafa M G Fouda,et al.  Antibacterial modification of cotton using nanotechnology. , 2013, Carbohydrate polymers.

[28]  R. Minchin,et al.  Nanomedicine: sizing up targets with nanoparticles. , 2008, Nature nanotechnology.

[29]  Narendra Kumar Jain,et al.  Functional polymeric nanoparticles: an efficient and promising tool for active delivery of bioactives. , 2006, Critical reviews in therapeutic drug carrier systems.

[30]  Z. Zaheer,et al.  Nanosponges – a completely new nano-horizon: pharmaceutical applications and recent advances , 2013, Drug development and industrial pharmacy.