The correlation between brain gray matter volume and empathizing and systemizing quotients in healthy children

The abilities to empathize and to systemize, two fundamental dimensions of cognitive style, are characterized by apparent individual differences. These abilities are typically measured using an empathizing quotient (EQ) and a systemizing quotient (SQ) questionnaire, respectively. The purpose of this study was to reveal any correlations between EQ and SQ scores and regional gray matter volumes in healthy children by applying voxel-based morphometry to magnetic resonance images. We collected MRIs of brain structure and administered children's versions of the EQ and SQ questionnaires (EQ-C and SQ-C, respectively) to 261 healthy children aged 5-15 years. Structural MRI data were segmented, normalized, and smoothed using an optimized voxel-based morphometric analysis. Next, we analyzed the correlation between regional gray matter volume and EQ-C and SQ-C scores adjusting for age, sex, and intracranial volume. The EQ-C scores showed significant positive correlations with the regional gray matter volumes of the left fronto-opercular and superior temporal cortices, including the precentral gyrus, the inferior frontal gyrus, the superior temporal gyrus, and the insula, which are functionally related to empathic processing. Additionally, SQ-C scores showed a significant negative correlation with the regional gray matter volume of the left posterior parietal cortex, which is functionally involved in selective attention processing. Our findings suggest that individual differences in cognitive style pertaining to empathizing or systemizing abilities could be explained by differences in the volume of brain structures that are functionally relevant to empathizing and systemizing.

[1]  Yasuyuki Taki,et al.  Breakfast Staple Types Affect Brain Gray Matter Volume and Cognitive Function in Healthy Children , 2010, PloS one.

[2]  Yasuyuki Taki,et al.  Regional gray matter density associated with emotional intelligence: Evidence from voxel‐based morphometry , 2011, Human brain mapping.

[3]  Judith A. Hall.  Gender Effects in Decoding Nonverbal Cues , 1978 .

[4]  J. Harris.  Where is the child's environment? A group socialization theory of development. , 1995 .

[5]  Yasuyuki Taki,et al.  Regional gray matter volume of dopaminergic system associate with creativity: Evidence from voxel-based morphometry , 2010, NeuroImage.

[6]  J. Kril,et al.  Language-associated cortical regions are proportionally larger in the female brain. , 1997, Archives of neurology.

[7]  Suzanne E. Welcome,et al.  Normal developmental changes in inferior frontal gray matter are associated with improvement in phonological processing: a longitudinal MRI analysis. , 2006, Cerebral cortex.

[8]  Lisa Feldman Barrett,et al.  Functional grouping and cortical–subcortical interactions in emotion: A meta-analysis of neuroimaging studies , 2008, NeuroImage.

[9]  T. Paus.  Mapping brain maturation and cognitive development during adolescence , 2005, Trends in Cognitive Sciences.

[10]  Simon Baron-Cohen,et al.  Systemizing influences attentional processes during the Navon task: An fMRI study , 2008, Neuropsychologia.

[11]  E. Redcay.  The superior temporal sulcus performs a common function for social and speech perception: Implications for the emergence of autism , 2008, Neuroscience & Biobehavioral Reviews.

[12]  Caterina Primi,et al.  Are systemizing and autistic traits related to talent and interest in mathematics and engineering? Testing some of the central claims of the empathizing-systemizing theory. , 2012, British journal of psychology.

[13]  Lisa Aziz-Zadeh,et al.  Common Premotor Regions for the Perception and Production of Prosody and Correlations with Empathy and Prosodic Ability , 2010, PloS one.

[14]  Sara C. Verosky,et al.  Mentalizing about emotion and its relationship to empathy. , 2008, Social cognitive and affective neuroscience.

[15]  J. Decety,et al.  How Would You Feel versus How Do You Think She Would Feel? A Neuroimaging Study of Perspective-Taking with Social Emotions , 2004, Journal of Cognitive Neuroscience.

[16]  S. Platek,et al.  Mindreading in individuals with an empathizing versus systemizing cognitive style: An fMRI study , 2010, Brain Research Bulletin.

[17]  S. Baron-Cohen,et al.  The Empathy Quotient: An Investigation of Adults with Asperger Syndrome or High Functioning Autism, and Normal Sex Differences , 2004, Journal of autism and developmental disorders.

[18]  Christian Keysers,et al.  Empathy for positive and negative emotions in the gustatory cortex , 2007, NeuroImage.

[19]  S. Baron-Cohen,et al.  The Children’s Empathy Quotient and Systemizing Quotient: Sex Differences in Typical Development and in Autism Spectrum Conditions , 2009, Journal of autism and developmental disorders.

[20]  Kazuyuki Aihara,et al.  Human posterior parietal cortex maintains color, shape and motion in visual short-term memory , 2008, Brain Research.

[21]  A. Toga,et al.  Mapping Continued Brain Growth and Gray Matter Density Reduction in Dorsal Frontal Cortex: Inverse Relationships during Postadolescent Brain Maturation , 2001, The Journal of Neuroscience.

[22]  Michael S. Gazzaniga,et al.  Empathizing and systemizing cognitive traits in the sciences and humanities , 2007 .

[23]  T. Singer,et al.  The empathic brain: how, when and why? , 2006, Trends in Cognitive Sciences.

[24]  Susan D. Voyer,et al.  Magnitude of sex differences in spatial abilities: a meta-analysis and consideration of critical variables. , 1995, Psychological bulletin.

[25]  J. Aharon-Peretz,et al.  Two systems for empathy: a double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions. , 2009, Brain : a journal of neurology.

[26]  Thomas E. Nichols,et al.  Nonstationary cluster-size inference with random field and permutation methods , 2004, NeuroImage.

[27]  Ingeborg Krägeloh-Mann,et al.  Global and local development of gray and white matter volume in normal children and adolescents , 2007, Experimental Brain Research.

[28]  M. Moscovitch,et al.  Top-down and bottom-up attention to memory: A hypothesis (AtoM) on the role of the posterior parietal cortex in memory retrieval , 2008, Neuropsychologia.

[29]  M Coltheart,et al.  Disturbed communication in schizophrenia: the role of poor pragmatics and poor mind-reading , 2002, Psychological Medicine.

[30]  Ralph Weidner,et al.  Zooming in and zooming out of the attentional focus: an FMRI study. , 2009, Cerebral cortex.

[31]  T. Singer.  The neuronal basis and ontogeny of empathy and mind reading: Review of literature and implications for future research , 2006, Neuroscience & Biobehavioral Reviews.

[32]  H. Loos,et al.  Synaptogenesis in human visual cortex — evidence for synapse elimination during normal development , 1982, Neuroscience Letters.

[33]  G. Rees,et al.  The structural basis of inter-individual differences in human behaviour and cognition , 2011, Nature Reviews Neuroscience.

[34]  Karl J. Friston,et al.  Statistical parametric maps in functional imaging: A general linear approach , 1994 .

[35]  R. Blair.  Responding to the emotions of others: Dissociating forms of empathy through the study of typical and psychiatric populations , 2005, Consciousness and Cognition.

[36]  Simon Baron-Cohen,et al.  Sally normal sex differences functioning autism , and − Asperger syndrome or high The systemizing quotient : an investigation of adults with , 2003 .

[37]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[38]  Akio Wakabayashi,et al.  Empathizing and Systemizing in Adults with and without Autism Spectrum Conditions: Cross-Cultural Stability , 2007, Journal of autism and developmental disorders.

[39]  D. Halpern.  Sex Differences in Cognitive Abilities , 1986 .

[40]  K. Pelphrey,et al.  Brain Mechanisms for Social Perception , 2008, Annals of the New York Academy of Sciences.

[41]  Rebecca C. Knickmeyer,et al.  Sex Differences in the Brain: Implications for Explaining Autism , 2005, Science.

[43]  Simon Baron-Cohen,et al.  Empathizing with basic emotions: Common and discrete neural substrates , 2006, Social neuroscience.

[44]  J. Astington,et al.  A longitudinal study of the relation between language and theory-of-mind development. , 1999, Developmental psychology.

[45]  S. Baron-Cohen.  The extreme male brain theory of autism , 2002, Trends in Cognitive Sciences.

[46]  P. Huttenlocher,et al.  Regional differences in synaptogenesis in human cerebral cortex , 1997, The Journal of comparative neurology.

[47]  E. Kaplan,et al.  Developmental sex differences in verbal learning. , 1997, Neuropsychology.

[48]  P. Huttenlocher.  Synaptic density in human frontal cortex - developmental changes and effects of aging. , 1979, Brain research.

[49]  R. Dworkin,et al.  Processing bias: individual differences in the cognition of situations. , 1985, Journal of personality.

[50]  S. Baron-Cohen.  Autism: The Empathizing–Systemizing (E‐S) Theory , 2009, Annals of the New York Academy of Sciences.

[51]  Diane F. Halpern,et al.  Sex differences in visuospatial working memory: Components of cognitive processing , 1999, Psychonomic bulletin & review.

[52]  Adrian Furnham,et al.  Explaining individual differences in scholastic behaviour and achievement. , 2005, The British journal of educational psychology.

[53]  J. Mazziotta,et al.  Neural mechanisms of empathy in humans: A relay from neural systems for imitation to limbic areas , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[54]  J. Talairach,et al.  Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging , 1988 .

[55]  G. Thierry,et al.  Renewal of the neurophysiology of language: functional neuroimaging. , 2005, Physiological reviews.

[56]  Akio Wakabayashi,et al.  [Individual and gender differences in Empathizing and Systemizing: measurement of individual differences by the Empathy Quotient (EQ) and the Systemizing Quotient (SQ)]. , 2006, Shinrigaku kenkyu : The Japanese journal of psychology.

[57]  E. McClure.  A meta-analytic review of sex differences in facial expression processing and their development in infants, children, and adolescents. , 2000, Psychological bulletin.

[58]  Daniel Nettle,et al.  Empathizing and systemizing: what are they, and what do they contribute to our understanding of psychological sex differences? , 2007, British journal of psychology.

[59]  Karl J. Friston,et al.  Voxel-Based Morphometry—The Methods , 2000, NeuroImage.

[60]  明雄 若林,et al.  Empathizing-Systemizing モデルによる性差の検討 , 2006 .

[61]  Karl J. Friston,et al.  A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains , 2001, NeuroImage.