Bioinformatics core competencies for undergraduate life sciences education

Bioinformatics is becoming increasingly central to research in the life sciences. However, despite its importance, bioinformatics skills and knowledge are not well integrated in undergraduate biology education. This curricular gap prevents biology students from harnessing the full potential of their education, limiting their career opportunities and slowing genomic research innovation. To advance the integration of bioinformatics into life sciences education, a framework of core bioinformatics competencies is needed. To that end, we here report the results of a survey of life sciences faculty in the United States about teaching bioinformatics to undergraduate life scientists. Responses were received from 1,260 faculty representing institutions in all fifty states with a combined capacity to educate hundreds of thousands of students every year. Results indicate strong, widespread agreement that bioinformatics knowledge and skills are critical for undergraduate life scientists, as well as considerable agreement about which skills are necessary. Perceptions of the importance of some skills varied with the respondent’s degree of training, time since degree earned, and/or the Carnegie classification of the respondent’s institution. To assess which skills are currently being taught, we analyzed syllabi of courses with bioinformatics content submitted by survey respondents. Finally, we used the survey results, the analysis of syllabi, and our collective research and teaching expertise to develop a set of bioinformatics core competencies for undergraduate life sciences students. These core competencies are intended to serve as a guide for institutions as they work to integrate bioinformatics into their life sciences curricula. Significance Statement Bioinformatics, an interdisciplinary field that uses techniques from computer science and mathematics to store, manage, and analyze biological data, is becoming increasingly central to modern biology research. Given the widespread use of bioinformatics and its impacts on societal problem-solving (e.g., in healthcare, agriculture, and natural resources management), there is a growing need for the integration of bioinformatics competencies into undergraduate life sciences education. Here, we present a set of bioinformatics core competencies for undergraduate life scientists developed using the results of a large national survey and the expertise of our working group of bioinformaticians and educators. We also present results from the survey on the importance of bioinformatics skills and the current state of integration of bioinformatics into biology education.

[1]  Lonnie Welch,et al.  Barriers to Integration of Bioinformatics into Undergraduate Life Sciences Education , 2017, bioRxiv.

[2]  Jason Williams,et al.  Unmet needs for analyzing biological big data: A survey of 704 NSF principal investigators , 2017, bioRxiv.

[3]  Monya Baker Scientific computing: Code alert , 2017 .

[4]  S. Hsi,et al.  Pilot Study Using the Augmented Reality Sandbox to Teach Topographic Maps and Surficial Processes in Introductory Geology Labs , 2016 .

[5]  Russell Schwartz,et al.  Applying, Evaluating and Refining Bioinformatics Core Competencies (An Update from the Curriculum Task Force of ISCB’s Education Committee) , 2016, PLoS Comput. Biol..

[6]  Lonnie Welch,et al.  The CourseSource Bioinformatics Learning Framework , 2016, CBE life sciences education.

[7]  Özlem Tastan Bishop,et al.  H3ABioNet, a sustainable pan-African bioinformatics network for human heredity and health in Africa , 2016, Genome research.

[8]  Mark A. Pauley,et al.  NIBLSE: A Network for Integrating Bioinformatics into Life Sciences Education , 2015, CBE life sciences education.

[9]  Tina Overton,et al.  Beyond Problem-Based Learning: Using Dynamic PBL in Chemistry. , 2015 .

[10]  Celia W. G. van Gelder,et al.  GOBLET: The Global Organisation for Bioinformatics Learning, Education and Training , 2015, PLoS Comput. Biol..

[11]  Aleksandra Pawlik,et al.  Data Carpentry: Workshops to Increase Data Literacy for Researchers , 2015 .

[12]  Jeremy Buhler,et al.  A Course-Based Research Experience: How Benefits Change with Increased Investment in Instructional Time , 2014, CBE life sciences education.

[13]  Deborah Grove,et al.  Vision and Change through the Genome Consortium for Active Teaching Using Next-Generation Sequencing (GCAT-SEEK) , 2014, CBE life sciences education.

[14]  Russell Schwartz,et al.  Bioinformatics Curriculum Guidelines: Toward a Definition of Core Competencies , 2014, PLoS Comput. Biol..

[15]  Wei Li,et al.  A Broadly Implementable Research Course in Phage Discovery and Genomics for First-Year Undergraduate Students , 2014, mBio.

[16]  Mary Lee S. Ledbetter,et al.  Vision and Change in Undergraduate Biology Education: A Call to Action Presentation to Faculty for Undergraduate Neuroscience, July 2011 , 2012, Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience.

[17]  Janet S Russell,et al.  The genome solver website: a virtual space fostering high impact practices for undergraduate biology. , 2012, Journal of microbiology & biology education.

[18]  Timothy P. Johnson,et al.  Response rates and nonresponse errors in surveys. , 2012, JAMA.

[19]  Simplifying Central Place Theory Using GIS and GPS , 2011 .

[20]  John R. Jungck,et al.  Bioinformatics education dissemination with an evolutionary problem solving perspective , 2010, Briefings Bioinform..

[21]  Jeffrey Parker,et al.  Bioinformatics and the Undergraduate Curriculum Essay , 2010, CBE life sciences education.

[22]  C. Kerfeld,et al.  Incorporating Genomics and Bioinformatics across the Life Sciences Curriculum , 2010, PLoS biology.

[23]  Tin Wee Tan,et al.  A proposed minimum skill set for university graduates to meet the informatics needs and challenges of the "-omics" era , 2009, BMC Genomics.

[24]  P. Pevzner,et al.  Computing Has Changed Biology—Biology Education Must Catch Up , 2009, Science.

[25]  D Lopatto,et al.  Genomics Education Partnership , 2008, Science.

[26]  Pratibha Varma-Nelson,et al.  Pedagogies of engagement in science: A comparison of PBL, POGIL, and PLTL , 2008, Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology.

[27]  Whole Genome Sequencing in the Undergraduate Classroom: Outcomes and Lessons from a Pilot Course , 2008 .

[28]  Ina Koch,et al.  A review of bioinformatics education in Germany , 2008, Briefings Bioinform..

[29]  A Malcolm Campbell,et al.  Genome Consortium for Active Teaching: meeting the goals of BIO2010. , 2007, CBE life sciences education.

[30]  W. Bialek,et al.  Introductory Science and Mathematics Education for 21st-Century Biologists , 2004, Science.

[31]  Jerry E Honts,et al.  Evolving strategies for the incorporation of bioinformatics within the undergraduate cell biology curriculum. , 2003, Cell biology education.

[32]  Division on Earth BIO2010: Transforming Undergraduate Education for Future Research Biologists , 2003 .

[33]  Ann L. Brown,et al.  How people learn: Brain, mind, experience, and school. , 1999 .

[34]  Thomas D. Snyder,et al.  Digest of Education Statistics , 1994 .