Cryptotanshinone inhibits LPS-induced proinflammatory mediators via TLR4 and TAK1 signaling pathway.

[1]  Jung-Hye Choi,et al.  Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages. , 2011, International immunopharmacology.

[2]  Peiqing Liu,et al.  Cryptotanshinone Suppressed Inflammatory Cytokines Secretion in RAW264.7 Macrophages through Inhibition of the NF-κB and MAPK Signaling Pathways , 2011, Inflammation.

[3]  I. Kang,et al.  Cryptotanshinone sensitizes DU145 prostate cancer cells to Fas(APO1/CD95)-mediated apoptosis through Bcl-2 and MAPK regulation. , 2010, Cancer letters.

[4]  J. Art,et al.  Regulation of the expression of inducible nitric oxide synthase. , 2010, Nitric oxide : biology and chemistry.

[5]  B. Choo,et al.  Anti-inflammatory Activity of Methylene Chloride Fraction From Glehnia littoralis Extract via Suppression of NF-κB and Mitogen-Activated Protein Kinase Activity , 2010 .

[6]  B. Choo,et al.  Anti-inflammatory activity of methylene chloride fraction from Glehnia littoralis extract via suppression of NF-kappa B and mitogen-activated protein kinase activity. , 2010, Journal of pharmacological sciences.

[7]  W. Lee,et al.  Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells. , 2009, Cancer letters.

[8]  Hyun Pyo Kim,et al.  Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge , 2008, Archives of pharmacal research.

[9]  W. Yeh,et al.  LPS/TLR4 signal transduction pathway. , 2008, Cytokine.

[10]  F. Cipollone,et al.  COX-2: friend or foe? , 2007, Current pharmaceutical design.

[11]  Lin-lin Yin,et al.  Cryptotanshinone inhibits cyclooxygenase-2 enzyme activity but not its expression. , 2006, European journal of pharmacology.

[12]  P. Cohen,et al.  Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex. , 2006, Molecular endocrinology.

[13]  S. Snyder,et al.  Inducible Nitric Oxide Synthase Binds, S-Nitrosylates, and Activates Cyclooxygenase-2 , 2005, Science.

[14]  S. Ryu,et al.  Molecular mechanisms of inhibitory activities of tanshinones on Lipopolysaccharide-lnduced nitric oxide generation in RAW 264.7 cells , 2004, Archives of pharmacal research.

[15]  A. Pautz,et al.  Regulation of the expression of inducible nitric oxide synthase. , 2004, European journal of pharmacology.

[16]  Shizuo Akira,et al.  Toll-like receptor signalling , 2004, Nature Reviews Immunology.

[17]  V. Cattell,et al.  Inducible nitric oxide synthase in inflammation , 1995, The Histochemical Journal.

[18]  R. Park,et al.  Tanshinone IIA from Salvia miltiorrhiza Inhibits Inducible Nitric Oxide Synthase Expression and Production of TNF-α, IL-1β and IL-6 in Activated RAW 264.7 Cells , 2003 .

[19]  Dayong Wu,et al.  Ceramide-induced and Age-associated Increase in Macrophage COX-2 Expression Is Mediated through Up-regulation of NF-κB Activity* , 2003, The Journal of Biological Chemistry.

[20]  K. Subbaramaiah,et al.  Cyclooxygenase 2: a molecular target for cancer prevention and treatment. , 2003, Trends in pharmacological sciences.

[21]  B. Beutler,et al.  Innate immune sensing and its roots: the story of endotoxin , 2003, Nature Reviews Immunology.

[22]  R. Park,et al.  Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-alpha, IL-1beta and IL-6 in activated RAW 264.7 cells. , 2003, Planta medica.

[23]  Hyun Pyo Kim,et al.  Effects of tanshinone I isolated from Salvia miltiorrhiza Bunge on arachidonic acid metabolism and in vivo inflammatory responses , 2002, Phytotherapy research : PTR.

[24]  S. Gross,et al.  Measurement of NO and NO Synthase , 1998, Current protocols in neuroscience.

[25]  S. Rhee,et al.  Murine TOLL-like Receptor 4 Confers Lipopolysaccharide Responsiveness as Determined by Activation of NFκB and Expression of the Inducible Cyclooxygenase* , 2000, The Journal of Biological Chemistry.

[26]  H. Petty,et al.  Cutting Edge: Lipopolysaccharide Induces Physical Proximity Between CD14 and Toll-Like Receptor 4 (TLR4) Prior to Nuclear Translocation of NF-κB1 , 2000, The Journal of Immunology.

[27]  S. Ryu,et al.  Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza. , 2000, Immunopharmacology.

[28]  Y. Vodovotz,et al.  Inducible Nitric Oxide Synthase and Inflammatory Diseases , 2000, Molecular medicine.

[29]  H. Petty,et al.  Lipopolysaccharide induces physical proximity between CD14 and toll-like receptor 4 (TLR4) prior to nuclear translocation of NF-kappa B. , 2000, Journal of immunology.

[30]  D. Golenbock,et al.  The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors. , 1999, Journal of immunology.

[31]  J. Dhainaut,et al.  LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock. , 1999, American journal of respiratory and critical care medicine.

[32]  L. Larivière,et al.  Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4) , 1999, The Journal of experimental medicine.

[33]  H. Nakano,et al.  Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1 , 1998 .

[34]  J. Vane,et al.  Cyclooxygenases 1 and 2. , 1998, Annual review of pharmacology and toxicology.

[35]  C. Nathan,et al.  Nitric oxide and macrophage function. , 1997, Annual review of immunology.

[36]  O. Griffith,et al.  Nitric oxide synthases: properties and catalytic mechanism. , 1995, Annual review of physiology.

[37]  M. Currie,et al.  L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. , 1994, Journal of medicinal chemistry.

[38]  S. Hart,et al.  Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. , 1992, The Journal of biological chemistry.

[39]  A Yagi,et al.  Possible Aktive Components of Tan-Shen (Salvia miltiorrhiza) for Protection of the Myocardium Against Ischemia-Induced Derangements , 1989, Planta medica.

[40]  W. Reutter,et al.  Galactosamine-induced sensitization to the lethal effects of endotoxin. , 1979, Proceedings of the National Academy of Sciences of the United States of America.