The promise of gene therapy in gastrointestinal and liver diseases

Gene therapy consists of the transfer of genetic material to cells to achieve a therapeutic goal. In the field of gastroenterology and hepatology gene therapy has produced considerable expectation as a potential tool in the management of conditions that lack effective therapy including non-resectable neoplasms of the liver, pancreas and gastrointestinal tract, chronic viral hepatitis unresponsive to interferon therapy, liver cirrhosis, and inflammatory bowel disease.

[1]  M. Neurath,et al.  Treatment of T Cell-Dependent Experimental Colitis in SCID Mice by Local Administration of an Adenovirus Expressing IL-18 Antisense mRNA , 2002, The Journal of Immunology.

[2]  J. Prieto,et al.  Protection against Woodchuck Hepatitis Virus (WHV) Infection by Gene Gun Coimmunization with WHV Core and Interleukin-12 , 2001, Journal of Virology.

[3]  Leaf Huang,et al.  Systemic production of IL‐12 by naked DNA mediated gene transfer: toxicity and attenuation of transgene expression in vivo , 2001, The journal of gene medicine.

[4]  J. Prieto,et al.  Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12 , 2001, Hepatology.

[5]  J. Reichen,et al.  Peginterferon alfa-2a in patients with chronic hepatitis C. , 2000, The New England journal of medicine.

[6]  J. Encke,et al.  Mouse alpha-fetoprotein-specific DNA-based immunotherapy of hepatocellular carcinoma leads to tumor regression in mice. , 2000, Gastroenterology.

[7]  J. Prieto,et al.  In vivo gene transfer of CD40 ligand into colon cancer cells induces local production of cytokines and chemokines, tumor eradication and protective antitumor immunity , 2000, Gene Therapy.

[8]  W. Reinisch,et al.  Transfer of interleukin-4 and interleukin-10 in patients with severe inflammatory bowel disease of the rectum. , 2000, Human gene therapy.

[9]  T. Pawlik,et al.  Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus. , 2000, Cancer research.

[10]  G. Ciliberto,et al.  Liver-Specific Alpha 2 Interferon Gene Expression Results in Protection from Induced Hepatitis , 2000, Journal of virology.

[11]  J. Prieto,et al.  Intratumoral Coinjection of Two Adenoviruses, One Encoding the Chemokine IFN-γ-Inducible Protein-10 and Another Encoding IL-12, Results in Marked Antitumoral Synergy1 , 2000, The Journal of Immunology.

[12]  R. Chen,et al.  Gene transfer into the CNS using recombinant adeno-associated virus: analysis of vector DNA forms resulting in sustained expression. , 1999, Journal of drug targeting.

[13]  J. Prieto,et al.  Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12 , 1999, Cancer Gene Therapy.

[14]  E. Schiff,et al.  Lamivudine as initial treatment for chronic hepatitis B in the United States. , 1999, The New England journal of medicine.

[15]  S. Kochanek,et al.  High-capacity adenoviral vectors for gene transfer and somatic gene therapy. , 1999, Human gene therapy.

[16]  J. Prieto,et al.  Intratumoral injection of bone-marrow derived dendritic cells engineered to produce interleukin-12 induces complete regression of established murine transplantable colon adenocarcinomas , 1999, Gene Therapy.

[17]  Yasuyuki Arakawa,et al.  Interferon Therapy Reduces the Risk for Hepatocellular Carcinoma: National Surveillance Program of Cirrhotic and Noncirrhotic Patients with Chronic Hepatitis C in Japan , 1999, Annals of Internal Medicine.

[18]  J. Lau Adeno-associated virus as a gene delivery vector for liver cells. , 1999, Journal of hepatology.

[19]  H. Büeler Adeno-Associated Viral Vectors for Gene Transfer and Gene Therapy , 1999, Biological chemistry.

[20]  J. Prieto,et al.  Different doses of adenoviral vector expressing IL-12 enhance or depress the immune response to a coadministered antigen: the role of nitric oxide. , 1999, Journal of immunology.

[21]  S. Cherry,et al.  Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[22]  Wei-Wei Zhang Development and application of adenoviral vectors for gene therapy of cancer , 1999, Cancer Gene Therapy.

[23]  M. Vidaud,et al.  Modeling the impact of interferon alfa treatment on liver fibrosis progression in chronic hepatitis C: a dynamic view. The Multivirc Group. , 1999, Gastroenterology.

[24]  J. Hoefs,et al.  Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group. , 1998, The New England journal of medicine.

[25]  William M. Lee,et al.  Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group. , 1998, The New England journal of medicine.

[26]  R. Sartor,et al.  Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice , 1998, Infection and Immunity.

[27]  R. Sherwin,et al.  Peroral gene therapy of lactose intolerance using an adeno-associated virus vector , 1998, Nature Medicine.

[28]  S. Yei,et al.  Ribozyme gene therapy for hepatitis C virus infection. , 1998, Clinical and diagnostic virology.

[29]  P. Daddona,et al.  Adenovirus-mediated transduction of intestinal cells in vivo. , 1998, Human gene therapy.

[30]  R. Schmid,et al.  Liposome mediated gene transfer into the rat oesophagus , 1997, Gut.

[31]  R. Weichselbaum,et al.  Gene therapy of cancer , 1997, The Lancet.

[32]  J. Kolls,et al.  In vivo and in vitro gene transfer and expression in rat intestinal epithelial cells by E1-deleted adenoviral vector. , 1997, Human gene therapy.

[33]  D. Kirn,et al.  Replicating viruses as selective cancer therapeutics. , 1996, Molecular medicine today.

[34]  M. Neurath,et al.  Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin‐10 or antibodies to interleukin‐12 , 1996, European journal of immunology.

[35]  N. Hayashi,et al.  In vivo gene transfer and expression in rat stomach by submucosal injection of plasmid DNA. , 1996, Human gene therapy.

[36]  F. Boyce,et al.  Baculovirus-mediated gene transfer into mammalian cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[37]  Brian Salmons,et al.  Virus vector design in gene therapy. , 1995, Molecular medicine today.

[38]  H. Blau,et al.  Gene therapy--a novel form of drug delivery. , 1995, The New England journal of medicine.

[39]  P. Hofschneider,et al.  Specific inhibition of hepatitis C viral gene expression by antisense phosphorothioate oligodeoxynucleotides. , 1995, Hepatology.

[40]  F. Ledley,et al.  Retroviral gene transfer into the intestinal epithelium. , 1995, Human gene therapy.

[41]  F. Ledley Nonviral gene therapy: the promise of genes as pharmaceutical products. , 1995, Human gene therapy.

[42]  G. Davis,et al.  Relationship between the presence of circulating anti-GOR and hepatitis C viremia/genotype. , 1995, Journal of hepatology.

[43]  P. Chang Somatic Gene Therapy , 1994 .

[44]  S. Kim,et al.  Human APC gene expression in rodent colonic epithelium in vivo using liposomal gene delivery. , 1994, Human molecular genetics.

[45]  E. Furth,et al.  Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[46]  M. Finegold,et al.  Improving access to intestinal stem cells as a step toward intestinal gene transfer. , 1994, Human gene therapy.

[47]  K. Rajewsky,et al.  Interleukin-10-deficient mice develop chronic enterocolitis , 1993, Cell.

[48]  X. Breakefield,et al.  Herpesvirus-mediated gene delivery into the rat brain: specificity and efficiency of the neuron-specific enolase promoter , 1993, Cellular and Molecular Neurobiology.

[49]  F. Graham,et al.  Packaging capacity and stability of human adenovirus type 5 vectors , 1993, Journal of virology.

[50]  G. Wilkinson,et al.  Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector. , 1992, Nucleic acids research.

[51]  P. Chanda,et al.  Adenovirus vectors for gene expression. , 1991, Current opinion in biotechnology.

[52]  J. Wands,et al.  Inhibition of hepatitis B virus by antisense oligodeoxynucleotides , 1991, The Lancet.

[53]  A. Allen,et al.  Polymeric structure of pig small-intestinal mucus glycoprotein. Dissociation by proteolysis or by reduction of disulphide bridges. , 1981, The Biochemical journal.

[54]  R. Samulski,et al.  Methods for adeno-associated virus-mediated gene transfer into muscle. , 2001, Methods in molecular biology.

[55]  N. Satyamurthy,et al.  8-[18F]Fluoropenciclovir: an improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET. , 2001, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[56]  T. Clackson,et al.  Regulated gene expression systems , 2000, Gene Therapy.

[57]  oseph,et al.  PEGINTERFERON ALFA-2a IN PATIENTS WITH CHRONIC HEPATITIS C AND CIRRHOSIS PEGINTERFERON ALFA-2a IN PATIENTS WITH CHRONIC HEPATITIS C AND CIRRHOSIS , 2000 .

[58]  M. Kay,et al.  Hepatic gene therapy using adeno-associated virus vectors. , 1999, Seminars in liver disease.

[59]  G. Kalpana Retroviral Vectors for Liver-directed Gene Therapy , 1999, Seminars in liver disease.

[60]  M. Kay,et al.  Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors , 1999, Nature Medicine.

[61]  A. Casalini,et al.  SV40 expression in human neoplastic and non-neoplastic tissues: perspectives on diagnosis, prognosis and therapy of human malignant mesothelioma. , 1998, Developments in biological standardization.

[62]  M. Lotze,et al.  Antitumor activities of IL-12 and mechanisms of action. , 1997, Chemical immunology.

[63]  I. Stratford,et al.  Targeting gene therapy to cancer: a review. , 1997, Oncology research.