Hot-melt extrudability of amorphous solid dispersions of flubendazole-copovidone: An exploratory study of the effect of drug loading and the balance of adjuvants on extrudability and dissolution.

[1]  Shuting Li,et al.  Improving chemical stability of resveratrol in hot melt extrusion based on formation of eutectic with nicotinamide. , 2021, International journal of pharmaceutics.

[2]  P. Tran,et al.  Recent studies on the processes and formulation impacts in the development of solid dispersions by hot-melt extrusion. , 2021, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[3]  D. Zacks,et al.  Pharmacologic activation of autophagy without direct mTOR inhibition as a therapeutic strategy for treating dry macular degeneration , 2021, Aging.

[4]  S. Carradori,et al.  Screening of Benzimidazole-Based Anthelmintics and Their Enantiomers as Repurposed Drug Candidates in Cancer Therapy , 2021, Pharmaceuticals.

[5]  C. Benmore,et al.  Amorphous dispersions of flubendazole in hydroxypropyl methylcellulose: formulation stability assisted by pair distribution function analysis. , 2021, International journal of pharmaceutics.

[6]  Srushti Tambe,et al.  Hot-melt extrusion: Highlighting recent advances in pharmaceutical applications , 2021, Journal of Drug Delivery Science and Technology.

[7]  C. Luebbert,et al.  Phase behavior of ASDs based on hydroxypropyl cellulose , 2020, International journal of pharmaceutics: X.

[8]  Suresh Bandari,et al.  Quality-by-design in hot melt extrusion based amorphous solid dispersions: An industrial perspective on product development. , 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[9]  Taowei Yang,et al.  Flubendazole, FDA-approved anthelmintic, Elicits Valid Antitumor Effects by Targeting P53 and Promoting Ferroptosis in Castration-resistant Prostate Cancer. , 2020, Pharmacological research.

[10]  Gabriela G Pereira,et al.  Polymer Selection for Hot-Melt Extrusion Coupled to Fused Deposition Modelling in Pharmaceutics , 2020, Pharmaceutics.

[11]  G. M. Gelfuso,et al.  Hot-Melt Extrusion as an Advantageous Technology to Obtain Effervescent Drug Products , 2020, Pharmaceutics.

[12]  David S. Jones,et al.  The design and development of high drug loading amorphous solid dispersion for hot-melt extrusion platform. , 2020, International journal of pharmaceutics.

[13]  N. Fotaki,et al.  Impact of Magnesium Stearate Presence and Variability on Drug Apparent Solubility Based on Drug Physicochemical Properties , 2020, The AAPS Journal.

[14]  John G. Lyons,et al.  An investigation of the inter-molecular interaction, solid-state properties and dissolution properties of mixed copovidone hot-melt extruded solid dispersions , 2019, Journal of Drug Delivery Science and Technology.

[15]  H. Xin,et al.  The Anthelmintic Flubendazole Blocks Human Melanoma Growth and Metastasis and Suppresses Programmed Cell Death Protein-1 and Myeloid-Derived Suppressor Cell Accumulation. , 2019, Cancer letters.

[16]  Wenling Fan,et al.  Application of the combination of ball-milling and hot-melt extrusion in the development of an amorphous solid dispersion of a poorly water-soluble drug with high melting point , 2019, RSC advances.

[17]  Evangelos Liamas,et al.  Hot melt extrusion of heat-sensitive and high melting point drug: Inhibit the recrystallization of the prepared amorphous drug during extrusion to improve the bioavailability. , 2019, International journal of pharmaceutics.

[18]  S. Billinge The rise of the X-ray atomic pair distribution function method: a series of fortunate events , 2019, Philosophical Transactions of the Royal Society A.

[19]  Marta F. Simões,et al.  Hot-melt extrusion in the pharmaceutical industry: toward filing a new drug application. , 2019, Drug discovery today.

[20]  M. F. de La Roca Soares,et al.  Combining amorphous solid dispersions for improved kinetic solubility of posaconazole simultaneously released from soluble PVP/VA64 and an insoluble ammonio methacrylate copolymer , 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[21]  A. Serajuddin,et al.  Effects of Surfactants on Itraconazole-HPMCAS Solid Dispersion Prepared by Hot-Melt Extrusion I: Miscibility and Drug Release. , 2019, Journal of pharmaceutical sciences.

[22]  G. Van den Mooter,et al.  Chemically identical but physically different: A comparison of spray drying, hot melt extrusion and cryo‐milling for the formulation of high drug loaded amorphous solid dispersions of naproxen , 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[23]  Zhiping Fan,et al.  Effect of plasticizers on manufacturing ritonavir/copovidone solid dispersions via hot‐melt extrusion: Preformulation, physicochemical characterization, and pharmacokinetics in rats , 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[24]  Geoff G. Z. Zhang,et al.  Relationship between amorphous solid dispersion in vivo absorption and in vitro dissolution: phase behavior during dissolution, speciation, and membrane mass transport , 2018, Journal of controlled release : official journal of the Controlled Release Society.

[25]  C. Gogos,et al.  Understanding the Processing Window of Hypromellose Acetate Succinate for Hot-Melt Extrusion, Part I: Polymer Characterization and Hot-Melt Extrusion , 2018 .

[26]  H. Zia,et al.  Selection of Solid-State Plasticizers as Processing Aids for Hot-Melt Extrusion. , 2018, Journal of pharmaceutical sciences.

[27]  Feng Zhang,et al.  An approach for chemical stability during melt extrusion of a drug substance with a high melting point. , 2017, International journal of pharmaceutics.

[28]  A. W. Ashton,et al.  Processing two-dimensional X-ray diffraction and small-angle scattering data in DAWN 2 , 2017, Journal of applied crystallography.

[29]  C. Benmore,et al.  Local Structure of Ion Pair Interaction in Lapatinib Amorphous Dispersions characterized by Synchrotron X-Ray diffraction and Pair Distribution Function Analysis , 2017, Scientific Reports.

[30]  H. Pataki,et al.  Oral bioavailability enhancement of flubendazole by developing nanofibrous solid dosage forms , 2017, Drug development and industrial pharmacy.

[31]  A. Nokhodchi,et al.  Continuous manufacturing via hot-melt extrusion and scale up: regulatory matters. , 2017, Drug discovery today.

[32]  G. Zografi,et al.  Interrelationships Between Structure and the Properties of Amorphous Solids of Pharmaceutical Interest. , 2017, Journal of pharmaceutical sciences.

[33]  G. Verreck,et al.  Evaluation of Three Amorphous Drug Delivery Technologies to Improve the Oral Absorption of Flubendazole , 2016, Journal of pharmaceutical sciences.

[34]  R. Williams,et al.  Challenges and Strategies in Thermal Processing of Amorphous Solid Dispersions: A Review , 2016, AAPS PharmSciTech.

[35]  M. Repka,et al.  Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation , 2015, AAPS PharmSciTech.

[36]  Rushiraj H Jani,et al.  Hot melt extrusion: An industrially feasible approach for casting orodispersible film , 2015 .

[37]  F. Peng,et al.  Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells , 2015, Oncotarget.

[38]  D. Worthen,et al.  Hydroxypropyl cellulose stabilizes amorphous solid dispersions of the poorly water soluble drug felodipine. , 2014, Carbohydrate polymers.

[39]  Q. Ping,et al.  Use of polymer combinations in the preparation of solid dispersions of a thermally unstable drug by hot-melt extrusion , 2013 .

[40]  K. Kolter Properties and Applications of Polyvinyllactam Polymers , 2013 .

[41]  Mohammed Maniruzzaman,et al.  A Review of Hot-Melt Extrusion: Process Technology to Pharmaceutical Products , 2012, ISRN pharmaceutics.

[42]  Simon J. L. Billinge,et al.  PDFgetX3: a rapid and highly automatable program for processing powder diffraction data into total scattering pair distribution functions , 2012, 1211.7126.

[43]  C. Lanusse,et al.  Exploring flubendazole formulations for use in sheep. Pharmacokinetic evaluation of a cyclodextrin-based solution , 2012, BMC Veterinary Research.

[44]  Chuanbin Wu,et al.  Improving the Chemical Stability of Amorphous Solid Dispersion with Cocrystal Technique by Hot Melt Extrusion , 2011, Pharmaceutical Research.

[45]  Martial Sauceau,et al.  New challenges in polymer foaming: A review of extrusion processes assisted by supercritical carbon dioxide , 2011 .

[46]  Yanbin Huang,et al.  A thermal analysis method to predict the complete phase diagram of drug-polymer solid dispersions. , 2010, International journal of pharmaceutics.

[47]  Feng Qian,et al.  Drug-polymer solubility and miscibility: Stability consideration and practical challenges in amorphous solid dispersion development. , 2010, Journal of pharmaceutical sciences.

[48]  Divyakant Desai,et al.  Lubrication in tablet formulations. , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[49]  Peng Wang,et al.  Effects of extrusion process parameters on the dissolution behavior of indomethacin in Eudragit E PO solid dispersions. , 2010, International journal of pharmaceutics.

[50]  P. York,et al.  Shear and extensional rheology of hydroxypropyl cellulose melt using capillary rheometry. , 2009, Journal of pharmaceutical and biomedical analysis.

[51]  Simon Bates,et al.  Characterization of amorphous API:Polymer mixtures using X-ray powder diffraction. , 2008, Journal of pharmaceutical sciences.

[52]  Yu Cao,et al.  Application of melt extrusion in the development of a physically and chemically stable high-energy amorphous solid dispersion of a poorly water-soluble drug. , 2008, Molecular pharmaceutics.

[53]  Charles E. Martin,et al.  Pharmaceutical Applications of Hot-Melt Extrusion: Part I , 2007, Drug development and industrial pharmacy.

[54]  Simon J. L. Billinge,et al.  PDFgetX2: a GUI-driven program to obtain the pair distribution function from X-ray powder diffraction data , 2004 .

[55]  Aditya Mohan Kaushal,et al.  Amorphous drug delivery systems: molecular aspects, design, and performance. , 2004, Critical reviews in therapeutic drug carrier systems.

[56]  P. Bracconi,et al.  Structural properties of magnesium stearate pseudopolymorphs: effect of temperature. , 2003, International journal of pharmaceutics.

[57]  M. Repka,et al.  Physical-mechanical, moisture absorption and bioadhesive properties of hydroxypropylcellulose hot-melt extruded films. , 2000, Biomaterials.