Efficacy of Peracetic Acid (EndoPA®) for Disinfection of Endoscopes.

Background/Aims We aimed to investigate the efficacy of peracetic acid (EndoPA® Firson Co., Ltd., Cheonan, Korea) in disinfecting endoscopes. Methods We prospectively investigated the gastroscopes (Part I) utilized in 100 gastroscopic examinations and colonoscopes (Part II) utilized in 30 colonoscopic examinations after disinfecting them with 0.2% peracetic acid (EndoPA® Firson Co., Ltd.). These instruments had been collected consecutively throughout the study period. We reprocessed and disinfected the endoscopes according to the guidelines for cleaning and disinfecting gastrointestinal endoscopes laid down by the Korean Society of Gastrointestinal Endoscopy in 2017. Three culture samples were obtained from each examination, based on different sampling methods. The primary outcome was a positive culture rate. Results In Part I of our study, two of 300 samples were positive. The culture positive rate after disinfection was 0.7% (2/300). The culture positive rate was not significantly different based on the exposure time to EndoPA® or the age of the scopes (p=0.7 or 0.2, respectively). In Part II of our study, all samples (n=90) were negative. Conclusions We conclude that 0.2% peracetic acid (EndoPA®) appears to be a good disinfectant for both gastroscopes and colonoscopes.

[1]  Young-Seok Cho,et al.  Korean Society of Gastrointestinal Endoscopy (KSGE) Guidelines for Endoscope Reprocessing , 2017 .

[2]  C. Sohn,et al.  Comparison of the efficacy of disinfectants in automated endoscope reprocessors for colonoscopes: tertiary amine compound (Sencron2®) versus ortho-phthalaldehyde (Cidex®OPA) , 2016, Intestinal research.

[3]  Z. Hongyan,et al.  In-Use Evaluation of Peracetic Acid for High-Level Disinfection of Endoscopes , 2016, Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates.

[4]  S. Hong,et al.  A Review of Current Disinfectants for Gastrointestinal Endoscopic Reprocessing , 2013, Clinical endoscopy.

[5]  Walter G. Park,et al.  Multisociety guideline on reprocessing flexible gastrointestinal endoscopes: 2011. , 2011, Gastrointestinal endoscopy.

[6]  Yunsheng Yang,et al.  Current status of cleaning and disinfection for gastrointestinal endoscopy in China: a survey of 122 endoscopy units. , 2011, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[7]  J. Rey,et al.  ESGE-ESGENA Guideline: cleaning and disinfection in gastrointestinal endoscopy. , 2008, Endoscopy.

[8]  W. Sokol.  Nine episodes of anaphylaxis following cystoscopy caused by Cidex OPA (ortho-phthalaldehyde) high-level disinfectant in 4 patients after cytoscopy. , 2004, The Journal of allergy and clinical immunology.

[9]  H. Lee,et al.  Value of Peracetic Acid (SCOTELIN(R)) for Endoscope Disinfection. , 2004 .

[10]  H. Lee,et al.  The Value of Peracetic Acid (SCOTELIN®) for Endoscopic Disinfection , 2004 .

[11]  S. V. Goddard,et al.  An evaluation of Cidex OPA (0.55% ortho-phthalaldehyde) as an alternative to 2% glutaraldehyde for high-level disinfection of endoscopes. , 2003, The Journal of hospital infection.

[12]  D. Izatt.  Endoscopic decontamination: an audit and practical review. , 2003, The Journal of hospital infection.

[13]  W A Rutala,et al.  Surface disinfection: should we do it? , 2001, The Journal of hospital infection.

[14]  A. Dimarino,et al.  GI endoscopic reprocessing practices in the United States. , 1999, Gastrointestinal endoscopy.

[15]  J. Sagripanti,et al.  Comparative sporicidal effect of liquid chemical germicides on three medical devices contaminated with spores of Bacillus subtilis. , 1996, American journal of infection control.

[16]  M. Uyeda,et al.  Transmission of Helicobacter pylori infection via flexible fiberoptic endoscopy. , 1996, American journal of infection control.

[17]  G. Ayliffe,et al.  Evaluation of the Steris System 1 Peracetic Acid Endoscope Processor. , 1995, The Journal of hospital infection.

[18]  Fred Silverstein,et al.  Transmission of Infection by Gastrointestinal Endoscopy and Bronchoscopy , 1993, Annals of Internal Medicine.

[19]  S. Crow.  Peracetic acid sterilization: a timely development for a busy healthcare industry. , 1992, Infection control and hospital epidemiology.

[20]  V. Fraser,et al.  Nosocomial infection and pseudoinfection from contaminated endoscopes and bronchoscopes--Wisconsin and Missouri. , 1991, MMWR. Morbidity and mortality weekly report.

[21]  E. Rauws,et al.  Patient-to-patient transmission of Campylobacter pylori infection by fiberoptic gastroduodenoscopy and biopsy. , 1990, The Journal of infectious diseases.