Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the co-morbidities of obesity Short title: Macrophage infiltration into fat depots

* These authors contributed equally to this work. 1Diabetes Unit and Internal Medicine C, 3Pathology Institute, 6Surgery Department A, Soroka Medical Center, Beer-Sheva, Israel, Medical Department III, University of Leipzig, Germany, 4The National Institute of Biotechnology in The Negev, The Department of Clinical Biochemistry, 7Department of Epidemiology, and 8the S. Daniel Abraham Center for Health and Nutrition, Faculty of Health Sciences, BenGurion University of the Negev, Beer-Sheva, Israel.

[1]  R. Kitazawa,et al.  MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. , 2006, The Journal of clinical investigation.

[2]  Avner Bar Hen,et al.  Increased Infiltration of Macrophages in Omental Adipose Tissue Is Associated With Marked Hepatic Lesions in Morbid Human Obesity , 2006, Diabetes.

[3]  J. Eckel,et al.  Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle. , 2006, Endocrinology.

[4]  R. Leibel,et al.  CCR2 modulates inflammatory and metabolic effects of high-fat feeding. , 2006, The Journal of clinical investigation.

[5]  Shupei Wang,et al.  Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans Published, JLR Papers in Press, September 8, 2005. DOI 10.1194/jlr.M500294-JLR200 , 2005, Journal of Lipid Research.

[6]  T. Olsson,et al.  0021-972X/05/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 90(10):5834–5840 Printed in U.S.A. Copyright © 2005 by The Endocrine Society doi: 10.1210/jc.2005-0369 A Unique Role of Monocyte Chemoattractant Protein 1 among Chemokines in Adipose , 2022 .

[7]  J. Schneider,et al.  Low plasma adiponectin levels are associated with increased hepatic lipase activity in vivo. , 2005, Diabetes care.

[8]  Jean-Daniel Zucker,et al.  Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. , 2005, Diabetes.

[9]  S. B. Pedersen,et al.  Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. , 2005, The Journal of clinical endocrinology and metabolism.

[10]  R. Busse,et al.  From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. , 2004, Diabetes.

[11]  K. Wellen,et al.  Obesity-induced inflammatory changes in adipose tissue. , 2003, The Journal of clinical investigation.

[12]  M. Desai,et al.  Obesity is associated with macrophage accumulation in adipose tissue. , 2003, The Journal of clinical investigation.

[13]  L. Tartaglia,et al.  Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. , 2003, The Journal of clinical investigation.

[14]  Anoop Misra,et al.  Clinical and pathophysiological consequences of abdominal adiposity and abdominal adipose tissue depots. , 2003, Nutrition.

[15]  A. Miller,et al.  Consumption of added fats and oils in the European Prospective Investigation into Cancer and Nutrition (EPIC) centres across 10 European countries as assessed by 24-hour dietary recalls , 2002, Public Health Nutrition.

[16]  P. Lewczuk,et al.  Elevated soluble intercellular adhesion molecule-1 levels in obesity: relationship to insulin resistance and tumor necrosis factor-alpha system activity. , 2002, Metabolism: clinical and experimental.

[17]  B. Wajchenberg.  Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. , 2000, Endocrine reviews.

[18]  R. Hanson,et al.  The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes. , 2000, Diabetes care.

[19]  A. Peters,et al.  Serum leptin is associated with serum uric acid concentrations in humans. , 1999, Metabolism: clinical and experimental.

[20]  J. Levine,et al.  Adipocyte macrophage colony-stimulating factor is a mediator of adipose tissue growth. , 1998, The Journal of clinical investigation.

[21]  M. Criqui,et al.  Does diet or alcohol explain the French paradox? , 1994, The Lancet.

[22]  R. DeFronzo,et al.  Glucose clamp technique: a method for quantifying insulin secretion and resistance. , 1979, The American journal of physiology.