The Preventive Effect of Brazilian Propolis on Metabolic

The Preventive Effect of Brazilian Propolis on Metabolic Syndrome Ken YASUKAWA, Yurika TSUDA, Tetsuya HARIGAYA, Yasuhito NOBUSHI, Shigetoshi TSUTSUMI, Keiichi MATSUZAKI, Yukinaga KISHIKAWA 1 Nihon University School of Pharmacy 2 Amazonfood Ltd. Objective: To show the preventive effect of Brazilian propolis on metabolic syndrome. Methods: Nine Brazilian propolis were examined for inhibition of α-glucosidase, absorption of sugar in mice, and lipid accumulation, glycerol 3-phosphate dehydrogenase, and adiponection production in mouse 3T3-L1 cells. Results: In nine Brazilian propolis, AF-06, AF-19, and AFG-06 propolis inhibited rat internal α -glucosidase, and AF-06 propolis inhibited the absorption of sugar in mice. In 3T3-L1 cells, AF-06 and AF-08 propolis inhibited accumulation lipid, and inhibited glycerol 3-phosphate dehydrogenase. Conclusion: Brazilian propolis AF-06 and AF-08 are natural products which offer promise in the prevention of diabetes and metabolic syndrome. Incorporating dietary supplements into a treatment plan with medicines with similar effects requires further

[1]  S. Shimba,et al.  Inhibitory effects of compounds isolated from the dried branches and leaves of murta (Myrceugenia euosma) on lipid accumulation in 3T3-L1 cells , 2016, Journal of Natural Medicines.

[2]  M. Kurokawa,et al.  Inhibitory Effects of Brazilian Propolis on Lipid Accumulation in 3T3-L1 Cells , 2014 .

[3]  M. Kurokawa,et al.  Inhibitory Effects of Brazilian Propolis on Tumor Promotion in Two-Stage Mouse Skin Carcinogenesis , 2012 .

[4]  M. Sofian‐Azirun,et al.  Antibacterial activity of propolis and honey against Staphylococcus aureus and Escherichia coli. , 2010 .

[5]  R. A. Laskar,et al.  Antioxidant activity of Indian propolis and its chemical constituents , 2010 .

[6]  A. Vollmar,et al.  Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis. , 2008, European journal of pharmacology.

[7]  W. Watanabe,et al.  Anti-Influenza Virus Activity of Propolis in Vitro and its Efficacy against Influenza Infection in Mice , 2008, Antiviral chemistry & chemotherapy.

[8]  P Zimmet,et al.  International Diabetes Federation: a consensus on Type 2 diabetes prevention , 2007, Diabetic medicine : a journal of the British Diabetic Association.

[9]  R. Kuster,et al.  Chemical composition and antibacterial activity of Brazilian propolis essential oil , 2010 .

[10]  T. Kawata,et al.  Anti-tumor effects of water-soluble propolis on a mouse sarcoma cell line in vivo and in vitro. , 2008, The American journal of Chinese medicine.