Medical and Neuropsychiatric Complications Associated with Use of the Intraaortic Balloon Pump

We conducted a retrospective chart review of 195 consecutive patients who had an intraaortic balloon pump (IABP) placed at the Massachusetts General Hospital during the calendar year 1988 to determine the incidence of complications associated with IABP treatment. Demographics, medical and psychiatric history, hospital course, medical and neuropsychiatric complications observed while on the IABP, pharmacological management, and outcome were recorded. Patients ranged in age from 26 to 81 years, with a mean of 62 years. Women comprised only 25% of the sample but had a mortality (40%) twice that of men (20%; p = 0.008). An IABP was inserted for cardiogenic shock in 52% of patients, for refractory angina in 36%, and intraoperatively in 12%. Patients were treated with an IABP for a mean of 4.4 days (range, several hours to 36 days). Complications included delirium (34%), mortality (25%), peripheral vascular insufficiency (17%), bleeding (14%), acute renal failure (14%), infection (8%), and stroke (4.6%). Delirium was associated only with a history of seizures and with development of a residual organic brain syndrome. Mortality was associated with female sex, cardiogenic shock, and number of complications present per patient. Vascular insufficiency was associated with female sex, history of peripheral vascular disease, valve replacement surgery, and mortality. Residual organic brain syndromes were more common in patients in whom delirium developed. A review of the literature on complications associated with IABP therapy is provided. This study highlights the common but previously unrecognized complication of delirium in IABP patients.