论文信息 - Funiculosin, a new antibiotic. II. Structure elucidation and antifungal activity.

Funiculosin, a new antibiotic. II. Structure elucidation and antifungal activity.

Structure elucidation and some biological properties of an antiviral and antifungal antibiotic, funiculosin, are summarized. Funiculosin is a derivative of N-methyl-4-hydroxy-3, 5-disubstituted-2-pyridone containing a novel substituent, cyclopentanetetrol moiety, that is reported here for the first time in a natural product. The antibiotic protects guinea pigs efficiently against experimental trichophytosis. Toxicity of funiculosin is unique and highly selective for animal species.

[1] L. P. Lindeman,et al. Carbon-13 nuclear magnetic resonance spectrometry. Chemical shifts for the paraffins through C9 , 1971 .

[2] K. Arima,et al. Studies on Antiviral and Antitumor Antibiotics:Part XVI. Screening of Antiviral Antibiotics by Paper-disc Agar-diffusion Plaque-inhibition Method , 1969 .

[3] K. Arima,et al. Funiculosin, a new antibiotic. I. Isolation, biological and chemical properties (studies on antiviral and antitumor antibiotics. 8). , 1969, The Journal of antibiotics.

[4] K. Ando,et al. Some biological properties of mycophenolic acid. , 1969, The Journal of antibiotics.

[5] M. Hilleman,et al. Inducers of interferon and host resistance. I. Double-stranded RNA from extracts of Penicillium funiculosum. , 1967, Proceedings of the National Academy of Sciences of the United States of America.

[6] E. C. Herrmann,et al. Agar Diffusion Method for Detection and Bioassay of Antiviral Antibiotics , 1960, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[7] J. A. Berson,et al. Spectra as a Guide to Structure in the Hydroxypyrone and Hydroxypyridone Series , 1956 .

[8] R. Shope. An antiviral substance from Penicillium funiculosum. II. Effect of helenine upon infection in mice with Semliki Forest virus. , 1953 .