Epitranscriptomic m ( 6 ) A Regulation of Axon Regeneration in the Adult Mammalian Nervous System

[1]  Hongyan Zou,et al.  Reshaping the chromatin landscape after spinal cord injury , 2014, Frontiers in Biology.

[2]  O. Steward,et al.  PTEN Deletion Enhances the Regenerative Ability of Adult Corticospinal Neurons , 2010, Nature Neuroscience.

[3]  J. Sanes,et al.  Subtype-Specific Regeneration of Retinal Ganglion Cells following Axotomy: Effects of Osteopontin and mTOR Signaling , 2015, Neuron.

[4]  H. Koerber,et al.  Sox11 transcription factor modulates peripheral nerve regeneration in adult mice , 2009, Brain Research.

[5]  Yuval Kluger,et al.  m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway , 2017, Nature.

[6]  Yang Wang,et al.  N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells , 2014, Nature Cell Biology.

[7]  Nathan Archer,et al.  m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination , 2016, Nature.

[8]  Chuan He,et al.  YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA , 2017, Cell Research.

[9]  Chuan He,et al.  N 6 -methyladenosine Modulates Messenger RNA Translation Efficiency , 2015, Cell.

[10]  Yun-Gui Yang,et al.  Cytoplasmic m6A reader YTHDF3 promotes mRNA translation , 2017, Cell Research.

[11]  Tingting Zou,et al.  Human m6A writers: Two subunits, 2 roles , 2017, RNA biology.

[12]  Zhike Lu,et al.  m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells , 2017, Cell reports.

[13]  G. Ming,et al.  DNA Modifications and Neurological Disorders , 2013, Neurotherapeutics.

[14]  G. Ming,et al.  Epigenetic mechanisms in neurogenesis , 2016, Nature Reviews Neuroscience.

[15]  J. Milbrandt,et al.  Dual Leucine Zipper Kinase Is Required for Retrograde Injury Signaling and Axonal Regeneration , 2012, Neuron.

[16]  Y. Wang,et al.  Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion , 2016, eNeuro.

[17]  Deepika Vuppalanchi,et al.  Axonally Synthesized β-Actin and GAP-43 Proteins Support Distinct Modes of Axonal Growth , 2013, The Journal of Neuroscience.

[18]  R. Desrosiers,et al.  Characterization of Novikoff hepatoma mRNA methylation and heterogeneity in the methylated 5' terminus. , 1975, Biochemistry.

[19]  Christopher E. Mason,et al.  Single-nucleotide resolution mapping of m6A and m6Am throughout the transcriptome , 2015, Nature Methods.

[20]  M. Poo,et al.  The cell biology of neuronal navigation , 2001, Nature Cell Biology.

[21]  Deanna S. Smith,et al.  A Transcription-Dependent Switch Controls Competence of Adult Neurons for Distinct Modes of Axon Growth , 1997, The Journal of Neuroscience.

[22]  Giovanni Coppola,et al.  A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program , 2016, Neuron.

[23]  C. Woolf,et al.  Selective up‐regulation of the growth arrest DNA damage‐inducible gene Gadd45 alpha in sensory and motor neurons after peripheral nerve injury , 2003, The European journal of neuroscience.

[24]  Chengqi Yi,et al.  N6-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO , 2011, Nature chemical biology.

[25]  Matthew L. K. Yip,et al.  The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation , 2017, Neuropsychopharmacology.

[26]  Erez Y. Levanon,et al.  m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation , 2015, Science.

[27]  J. Goldberg,et al.  Multiple transcription factor families regulate axon growth and regeneration , 2011, Developmental neurobiology.

[28]  Arne Klungland,et al.  ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. , 2013, Molecular cell.

[29]  O. Elemento,et al.  Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons , 2012, Cell.

[30]  Kristen M. Naegle,et al.  Injury-Induced HDAC5 Nuclear Export Is Essential for Axon Regeneration , 2013, Cell.

[31]  Eran Perlson,et al.  Vimentin-Dependent Spatial Translocation of an Activated MAP Kinase in Injured Nerve , 2005, Neuron.

[32]  Byung C. Yoon,et al.  Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair , 2012, Nature Reviews Neuroscience.

[33]  Jaewon Park,et al.  Dynamic m6A modification regulates local translation of mRNA in axons , 2017, Nucleic acids research.

[34]  M. Gambello,et al.  Mammalian Target of Rapamycin (mTOR) Activation Increases Axonal Growth Capacity of Injured Peripheral Nerves* , 2010, The Journal of Biological Chemistry.

[35]  Stefan Canzar,et al.  Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation , 2017, Cell.

[36]  Hongyan Zou,et al.  Epigenetic Regulation of Sensory Axon Regeneration after Spinal Cord Injury , 2013, The Journal of Neuroscience.

[37]  Philippe Pierre,et al.  SUnSET, a nonradioactive method to monitor protein synthesis , 2009, Nature Methods.

[38]  V. Cavalli,et al.  Filamin A Is Required in Injured Axons for HDAC5 Activity and Axon Regeneration* , 2015, The Journal of Biological Chemistry.

[39]  Chuan He,et al.  Post-transcriptional gene regulation by mRNA modifications , 2016, Nature Reviews Molecular Cell Biology.

[40]  J. Steen,et al.  Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics , 2015, Neuron.

[41]  C. Woolf,et al.  ATF3 Increases the Intrinsic Growth State of DRG Neurons to Enhance Peripheral Nerve Regeneration , 2007, The Journal of Neuroscience.

[42]  Philippe Pierre,et al.  Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[43]  D. Geschwind,et al.  Novel Roles for Osteopontin and Clusterin in Peripheral Motor and Sensory Axon Regeneration , 2014, The Journal of Neuroscience.

[44]  T. Bredy,et al.  Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice , 2016, The Journal of Neuroscience.

[45]  F. Liu,et al.  m6A modulates haematopoietic stem and progenitor cell specification , 2017, Nature.

[46]  Michael Costigan,et al.  Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. , 2002, BMC Neuroscience.

[47]  Chuan He,et al.  m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition , 2016, Nature.

[48]  G. Ming,et al.  Neuronal activity modifies the chromatin accessibility landscape in the adult brain , 2017, Nature Neuroscience.

[49]  G. Ming,et al.  Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond , 2011, Cell cycle.

[50]  Shaoqiu He,et al.  Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain , 2016, Neuron.

[51]  S. Di Giovanni,et al.  The histone acetyltransferase p300 promotes intrinsic axonal regeneration. , 2011, Brain : a journal of neurology.

[52]  W. Gilbert,et al.  Messenger RNA modifications: Form, distribution, and function , 2016, Science.

[53]  Gerald J. Sun,et al.  In Vivo Clonal Analysis Reveals Self-Renewing and Multipotent Adult Neural Stem Cell Characteristics , 2011, Cell.

[54]  M. Tuszynski,et al.  Molecular and Cellular Mechanisms of Axonal Regeneration After Spinal Cord Injury* , 2015, Molecular & Cellular Proteomics.

[55]  J. Verhaagen,et al.  Overexpression of ATF3 or the combination of ATF3, c-Jun, STAT3 and Smad1 promotes regeneration of the central axon branch of sensory neurons but without synergistic effects. , 2015, Human molecular genetics.

[56]  Tianlei Xu,et al.  Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis. , 2017, Human molecular genetics.

[57]  G. Ming,et al.  An Intrinsic Epigenetic Barrier for Functional Axon Regeneration , 2017, Neuron.

[58]  Chengqi Yi,et al.  Epitranscriptome sequencing technologies: decoding RNA modifications , 2016, Nature Methods.

[59]  R. Gregory,et al.  The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. , 2016, Molecular cell.

[60]  Åsa K. Björklund,et al.  Full-length RNA-seq from single cells using Smart-seq2 , 2014, Nature Protocols.

[61]  Kai-Fenp Liu,et al.  Neuronal intrinsic mechanisms of axon regeneration. , 2011, Annual review of neuroscience.

[62]  A. Mele,et al.  Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis , 2014, Nature Protocols.

[63]  Olivier Elemento,et al.  5′ UTR m6A Promotes Cap-Independent Translation , 2015, Cell.

[64]  A. Tedeschi,et al.  Spatial and temporal arrangement of neuronal intrinsic and extrinsic mechanisms controlling axon regeneration , 2017, Current Opinion in Neurobiology.

[65]  A. Tessler,et al.  In Vivo Imaging of Dorsal Root Regeneration: Rapid Immobilization and Presynaptic Differentiation at the CNS/PNS Border , 2011, The Journal of Neuroscience.

[66]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[67]  Zhigang He,et al.  Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway , 2008, Science.

[68]  Arne Klungland,et al.  A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation , 2015, Genes & development.

[69]  G. Ming,et al.  Epigenetic regulation of axonal regenerative capacity. , 2016, Epigenomics.

[70]  R. Darnell,et al.  Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data , 2011, Nature Biotechnology.

[71]  A. Diantonio,et al.  Dynamic regulation of SCG10 in regenerating axons after injury , 2014, Experimental Neurology.

[72]  Miguel A. Andrade-Navarro,et al.  m6A modulates neuronal functions and sex determination in Drosophila , 2016, Nature.

[73]  Yi Xing,et al.  m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. , 2014, Cell stem cell.

[74]  M. Kupiec,et al.  Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq , 2012, Nature.

[75]  T. Nguyen,et al.  PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system , 2014, Nature Communications.

[76]  V. Cavalli,et al.  HDAC signaling in neuronal development and axon regeneration , 2014, Current Opinion in Neurobiology.

[77]  M. Fainzilber,et al.  Axon–soma communication in neuronal injury , 2013, Nature Reviews Neuroscience.