CPT: Pharmacometrics & Systems Pharmacology

QSP-10 APPLICATION OF AN IN SILICO PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL TO SIMULATE ORAL DRUG BIOAVAILABILITY OF ATORVASTATIN ACID AND CYCLOSPORINE POST BARIATRIC SURGERY. A. S. Darwich,1 D. Pade,2 K. Rowland-Yeo,2 M. Jamei,2 A. Åsberg,3 H. Christensen,3 D. M. Ashcroft,1 A. Rostami-Hodjegan1; 1Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom, 2Simcyp Ltd, Blades Enterprise Centre, Sheffield, United Kingdom, 3Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway. A.S. Darwich: None. D. Pade: 2. I am a paid consultant/employee for Company/Drug; Simcyp Ltd. K. Rowland-Yeo: 2. I am a paid consultant/employee for Company/ Drug; Simcyp Ltd. M. Jamei: 2. I am a paid consultant/employee for Company/Drug; Simcyp Ltd. A. Åsberg: None. H. Christensen: None. D.M. Ashcroft: None. A. Rostami-Hodjegan: 2. I am a paid consultant/employee for Company/Drug; Simcyp Ltd. 5. I am a significant stockholder for Company/Drug; Simcyp Ltd.