Utilizing the hair follicle to dissect the regulation and autocrine/paracrine activities of prolactin in humans.

to the editor: Ferraris et al. ([4][1]) have recently reported an increase in anterior pituitary cell proliferation in Δ1-9-G129R-hPRL (competitive prolactin receptor antagonist) -expressing transgenic mice compared to wild-type controls. In addition, they reported increased proliferation/decreased

[1]  R. Paus,et al.  Endocannabinoids limit excessive mast cell maturation and activation in human skin. , 2012, The Journal of allergy and clinical immunology.

[2]  M. Bernadet,et al.  Prolactin receptor antagonism in mouse anterior pituitary: effects on cell turnover and prolactin receptor expression. , 2012, American journal of physiology. Endocrinology and metabolism.

[3]  G. Idelman,et al.  Dopamine Receptors in Human Adipocytes: Expression and Functions , 2011, PloS one.

[4]  S. Basu,et al.  Dopamine Regulates Angiogenesis in Normal Dermal Wound Tissues , 2011, PloS one.

[5]  Y. Ramot,et al.  Prolactin: an emerging force along the cutaneous–endocrine axis , 2010, Trends in Endocrinology & Metabolism.

[6]  Y. Ramot,et al.  Prolactin—a novel neuroendocrine regulator of human keratin expression in situ , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[7]  Y. Ramot,et al.  Thyrotropin‐releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles in vitro , 2010, The British journal of dermatology.

[8]  R. Paus,et al.  Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture , 2010, Experimental dermatology.

[9]  Y. Ramot,et al.  Mind the (gender) gap: does prolactin exert gender and/or site-specific effects on the human hair follicle? , 2010, The Journal of investigative dermatology.

[10]  N. Ben-Jonathan,et al.  What can we learn from rodents about prolactin in humans? , 2008, Endocrine reviews.

[11]  R. Paus,et al.  Towards the development of a simplified long‐term organ culture method for human scalp skin and its appendages under serum‐free conditions , 2007, Experimental dermatology.

[12]  Julian R. E. Davis,et al.  Prolactin in man: a tale of two promoters , 2006, BioEssays : news and reviews in molecular, cellular and developmental biology.

[13]  R. Paus,et al.  Human scalp hair follicles are both a target and a source of prolactin, which serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle regression. , 2006, The American journal of pathology.

[14]  A. Suzuki,et al.  Dopamine D2-like receptor agonists accelerate barrier repair and inhibit the epidermal hyperplasia induced by barrier disruption. , 2005, The Journal of investigative dermatology.

[15]  R. Paus,et al.  Prolactin and its receptor are expressed in murine hair follicle epithelium, show hair cycle-dependent expression, and induce catagen. , 2003, The American journal of pathology.

[16]  P. Kelly,et al.  Should prolactin be reconsidered as a therapeutic target in human breast cancer? , 1999, Molecular and Cellular Endocrinology.

[17]  G. Girolomoni,et al.  Prolactin stimulates proliferation of cultured human keratinocytes. , 1993, The Journal of investigative dermatology.

[18]  S. Arkins,et al.  Prolactin synthesized and secreted by human peripheral blood mononuclear cells: an autocrine growth factor for lymphoproliferation. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[19]  S. Handwerger,et al.  Failure of bromocriptine, dopamine, and thyrotropin-releasing hormone to affect prolactin secretion by human decidual tissue in vitro. , 1979, The Journal of clinical endocrinology and metabolism.

[20]  A. Meikle.  Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors , 2011 .

[21]  M. Postel-Vinay,et al.  Reprints Available Directly from the Publisher Photocopying Permitted by License Only Role of Prolactin and Growth Hormone on Thymus Physiology , 2022 .