NSABP-32: Phase III, randomized trial comparing axillary resection with sentinal lymph node dissection: A description of the trial

The NSABP-32 trial is a randomized, phase III clinical trial to compare sentinel node (SN) resection to conventional axillary dissection in clinically node-negative breast cancer patients. The primary aims of the trial are to determine if removal of only SNs provides survival and regional control equivalent to those of axillary dissection, while diminishing the magnitude of surgically related side effects. In order to ensure consistency of the outcomes for this trial, a standardized method of SN surgery has been utilized for all cases. A secondary aim of the B32 trial is to evaluate whether patients with “occult” metastases in the SNs have worse survival. Accrual is taking place at 73 institutions in North America, and 217 surgeons are enrolling patients.

[1]  K. Bland,et al.  Axillary dissection in breast-conserving surgery for stage I and II breast cancer: a National Cancer Data Base study of patterns of omission and implications for survival. , 1999, Journal of the American College of Surgeons.

[2]  Frcr,et al.  Breast conservation in the treatment of early breast cancer a 20‐year follow‐up , 1984, Cancer.

[3]  Mike Clarke,et al.  Polychemotherapy for early breast cancer: an overview of the randomised trials , 1998, The Lancet.

[4]  R. Orr.  The Impact of Prophylactic Axillary Node Dissection on Breast Cancer Survival—A Bayesian Meta-Analysis , 1999, Annals of surgical oncology.

[5]  S. Kaae,et al.  Simple mastectomy with postoperative irradiation versus extended radical mastectomy in breast cancer. A twenty-five-year follow-up of a randomized trial. , 1990, Acta oncologica.

[6]  T. Hamilton,et al.  A clinical trial in the management of operable cancer of the breast , 1980, The British journal of surgery.

[7]  Jong-Hyeon Jeong,et al.  Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. , 2002, The New England journal of medicine.

[8]  J. Hayward,et al.  Treatment of Early Breast Cancer: A Report after Ten Years of a Clinical Trial , 1972, British medical journal.

[9]  B. Asselain,et al.  Value of axillary dissection in addition to lumpectomy and radiotherapy in early breast cancer , 1992, The Lancet.

[10]  B. Fisher,et al.  Number of lymph nodes examined and the prognosis of breast carcinoma. , 1970, Surgery, gynecology & obstetrics.

[11]  B Fisher,et al.  Ten-year results of a randomized clinical trial comparing radical mastectomy and total mastectomy with or without radiation. , 1985, The New England journal of medicine.